A comprehensive insight into the role of molecular pathways affected by the Angiopoietin and Tie system involved in hematological malignancies' pathogenesis

Angiogenesis has been recognized as a critical factor in developing solid tumors and hematological malignancies. How angiogenesis affects the molecular pathways in malignancies is still a mystery. The angiopoietin family, one of the known molecular mediators for angiogenesis, encourages angiogenesis by attaching to Tie receptors on cell surfaces. Angiopoietin, Tie, and particularly the molecular pathways they mediate have all been the subject of recent studies that have established their diagnostic, prognostic, and therapeutic potential. Here, we've reviewed the function of molecular pathways impacted by the Angiogenin and Tie system in hematological malignancies.

Automated summary

Angiogenesis is a critical factor in the development of solid tumors and hematological malignancies, but its impact on molecular pathways in malignancies remains unclear. The angiopoietin family, specifically Angiogenin and Tie, have been studied for their diagnostic, prognostic, and therapeutic potential. This review focuses on the function of the molecular pathways affected by the Angiogenin and Tie system in hematological malignancies.