4.5 Article

Clinicopathological significance and the associated signaling pathway of p21-activated kinase 1 (PAK1) in colorectal cancer

Journal

PATHOLOGY RESEARCH AND PRACTICE
Volume 251, Issue -, Pages -

Publisher

ELSEVIER GMBH
DOI: 10.1016/j.prp.2023.154820

Keywords

Colorectal cancer; PAK1; HIF-1 alpha; PFOXO1; Immunohistochemistry; Prognosis

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The aim of this study was to evaluate the clinicopathological significance and associated signaling pathways of p21-activated kinase 1 (PAK1) in colorectal cancer (CRC). The results showed that PAK1 expression was significantly correlated with metastatic lymph node ratio and low immunoscore, as well as high expression of HIF-1 alpha and pFOXO1 in CRC. PAK1 expression was also associated with worse prognosis in CRC patients.
The aim of this study was to evaluate the clinicopathological significance and associated signaling pathways of p21-activated kinase 1 (PAK1) in colorectal cancer (CRC). PAK1 immunohistochemical expression was investigated in 246 human CRC tissues to evaluate its clinicopathological significance and prognostic role. Correlations between PAK1 and the immunoscore, HIF-1 alpha, and pFOXO1 were also evaluated. PAK1 was expressed in 169 of 246 CRC tissues (68.7%). PAK1 expression significantly correlated with the metastatic lymph node ratio (P = 0.023). However, PAK1 expression did not correlate with tumor size, tumor location, tumor differentiation, lymphovascular and perineural invasion, or distant metastasis. PAK1 expression was significantly higher in CRC with a low immunoscore than in CRC with a high immunoscore (P = 0.017). In addition, there were significant correlations between PAK1, HIF-1 alpha, and pFOXO1 expression (P = 0.001 and P = 0.024, respectively). Patients with PAK1 expression had worse overall and recurrence-free survival than those without PAK1 expression (P 0.001 and P = 0.001, respectively). PAK1 expression was significantly correlated with worse prognosis in CRCs patients. In addition, PAK1 expression was significantly correlated with a low immunoscore and high expression of HIF-1 alpha and pFOXO1 in CRCs.

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