LncRNA SNHG12: A budding star in human diseases

Small nucleolar RNA host gene 12 (SNHG12) is a long non-coding RNA (lncRNA) that contributes in a variety of human pathologies. This lncRNAs acts as molecular sponge for various miRNAs, namely miR-200c-5p, miR129-5p, miR-30a-3p, miR-195, miR-133b, miR-199a/b-5p, miR-320b, miR-16, miR-15a, miR-218-5p, miR-320 and a number of other miRNAs. Through this mechanism, SNHG12 can affect activity of HIF-1 alpha, Wnt/beta-catenin, VEGF, PI3K/AKT/mTOR, PTEN, NF-kappa B and ERK-1/2 signaling. SNHG12 can affect pathogenesis of several disorders, including those arising from genitourinary, gastrointestinal, pulmonary, central nervous and cardiovascular systems. These effects have been best characterized in the context of cancer where it can be used as a possible diagnostic and prognostic marker. In order to summarize the role of this lncRNA in human disorders, particularly cancer and highlight its potential application in biomedical studies, we designed the current review. We also emphasized on its diagnostic and prognostic roles.

Automated summary

SNHG12, a lncRNA, plays a role in various human pathologies. It acts as a molecular sponge for multiple miRNAs, affecting the activity of several signaling pathways. It has been implicated in the pathogenesis of different diseases, particularly cancer, and could be a potential diagnostic and prognostic marker.