Cu2SnTe3 Nanoparticles for Chemodynamic/Photodynamic /Photothermal Combination Tumor Therapy

Cancer is a serious threat to human life. However, the effect of single treatment method is limited at present. Here, a Cu2SnTe3 (CST) nano-reagent which can provide a strong synergetic effect in tumor therapy is successfully constructed. CST nanoparticles can not only convert endogenous H2O2 into & BULL;OH through surface-catalyzed reactions, but also generate O-1(2) based on light irradiation-induced electron pair separation, leading to excessive oxidative stress accumulation in tumor cells. Interestingly, CST nanoparticles are also found to possess catalase-like activity, which enhances the level of O-2 within hypoxic tumors, further improving the production efficiency of O-1(2) by photodynamic therapy (PDT). In addition, the CST nanoparticles exhibit good photothermal conversion, which facilitates to promote more (OH)-O-& BULL; production by chemodynamic therapy (CDT). The results of in vitro and in vivo anti-tumor experiments both demonstrate that CST nanoparticles can effectively inhibit the growth of tumor with minimal side effects. To sum up, CST nanoparticles have great potential in tumor treatment for efficient synergetic CDT/PDT/photothermal therapy.

Automated summary

The Cu2SnTe3 (CST) nano-reagent is able to effectively inhibit tumor growth through a strong synergetic effect in chemodynamic therapy (CDT), photodynamic therapy (PDT), and photothermal therapy. CST nanoparticles convert H2O2 into *OH and generate O-1(2) through surface-catalyzed reactions and light irradiation-induced electron pair separation, leading to oxidative stress accumulation in tumor cells. The nanoparticles also possess catalase-like activity, enhancing O-2 levels within hypoxic tumors and the production efficiency of O-1(2) by PDT.