Synthesis of a-Hydroxyl and a-Amino Pyridinyl Esters via Photoreductive Dual Radical Cross-Coupling

A method for the synthesis of a-hydroxyl and a-amino pyridinyl esters via photoreductive dual radical cross-coupling catalyzed by the super-organoreductant CBZ6 has been developed. A wide range of 2-pyridinylation and 4-pyridinylation of either a-ketoesters or imine derivatives has been achieved. The applications in the synthesis of pyridinyl amino-hydroxyl acids as well as a new chiral oxazoline ligand have also been accomplished.

Automated summary

A method for synthesizing a-hydroxyl and a-amino pyridinyl esters via photoreductive dual radical cross-coupling catalyzed by the super-organoreductant CBZ6 has been developed. Wide range of 2-pyridinylation and 4-pyridinylation reactions of either a-ketoesters or imine derivatives have been achieved. Applications in the synthesis of pyridinyl amino-hydroxyl acids as well as a new chiral oxazoline ligand have also been accomplished.