Journal
ORGANIC LETTERS
Volume 25, Issue 43, Pages 7890-7894Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c03123
Keywords
-
Categories
Ask authors/readers for more resources
In this study, we describe a scandium-catalyzed regioselective synthesis of 5-carbonyl-4-hydroxybenzofurans via a phenol-directed intramolecular Friedel-Crafts reaction. This method was successfully applied for the total synthesis of furanoflavones. Experimental and theoretical calculations suggest that hydrogen bond interactions between the phenolic hydroxy group and the scandium complex enable regioselective intramolecular cyclization.
Herein we report a scandium-catalyzed regioselective synthesis of 5-carbonyl-4-hydroxybenzofurans via a phenol-directed intramolecular Friedel-Crafts reaction. This synthetic method was applied for the total synthesis of furanoflavones. Experimental studies and density functional theory calculations suggest that hydrogen bond interactions between the phenolic hydroxy group and the scandium complex realize regioselective intramolecular cyclization.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available