Journal
ORGANIC LETTERS
Volume 25, Issue 39, Pages 7073-7077Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c01934
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A novel copper-catalyzed cross-dehydrogenative-coupling (CDC) process has been developed for the straightforward synthesis of alpha-aryl-alpha-heteroaryl alpha-amino acid scaffolds using arylglycine derivatives and N-heteroarenes. This protocol demonstrates a wide substrate scope and good functional group compatibility by utilizing air as the sole oxidant. The reaction also allows for late-stage functionalization of arylglycines bearing natural compounds or drug motifs.
A novel copper-catalyzed cross-dehydrogenative-coupling (CDC) process of arylglycine derivatives with N-heteroarenes for the straightforward synthesis of alpha-aryl-alpha-heteroaryl alpha-amino acid scaffolds has been successfully developed. This protocol exhibits a broad substrate scope with good functional group compatibility by utilizing air as the sole oxidant. The use of the reaction is also displayed through the late-stage functionalization of arylglycines bearing natural compounds or drug motifs.
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