Cp*Rh(III)-Catalyzed ortho-Alkylation/Alkenylation of Nitroarenes

Cp*Rh(III)-catalyzednitro-directed C-H alkylation/alkenylationof nitroarenes has been reported for the first time. This protocolis associated with the features of high efficiency, broad substratescope, and good functional group compatibility. Additionally, gram-scaleexperiments and synthetic applications proved the practicability ofthe method. Moreover, preliminary mechanistic investigations consistentlyrevealed C-H bond cleavage as the rate-limiting step.

Automated summary

The Cp*Rh(III)-catalyzed nitro-directed C-H alkylation/alkenylation of nitroarenes has been reported for the first time. This method exhibits high efficiency, broad substrate scope, and good functional group compatibility. Gram-scale experiments and synthetic applications confirmed the practicality of this method. Furthermore, preliminary mechanistic investigations consistently indicated that C-H bond cleavage is the rate-limiting step.