Nickel-Catalyzed Reductive Decarboxylative/Deaminative Glycosylation of Activated Aliphatic Acids and Primary Amines

This study describes the nickel-catalyzed reductive decarboxylative/deaminativeglycosylation of activated aliphatic acids/amines. Various alkyl C-glycosides were efficiently constructed under simple andmild reaction conditions. The reactions were high-yielding and exhibiteda broad substrate scope, thereby enabling the transformation of somestructurally complex natural products and late-stage modificationsof drugs.

Automated summary

This study describes a nickel-catalyzed reductive decarboxylative/deaminative glycosylation of activated aliphatic acids/amines, resulting in efficient construction of various alkyl C-glycosides under simple and mild reaction conditions. The reactions exhibited high yields and broad substrate scope, enabling the transformation of some structurally complex natural products and late-stage modifications of drugs.