Journal
ORGANIC LETTERS
Volume 25, Issue 42, Pages 7639-7644Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c02949
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The dynamic covalent chemistry of imines is used to synthesize an unsymmetric (C-1) chiral macrocycle from the reaction of an unsymmetric (C-1) chiral dialdehyde with lysine. The enantioselectivity is enhanced in the presence of Zn2+. The resulting compound is a highly selective fluorescent probe for lysine.
The dynamic covalent chemistry of imines is utilized to conduct a regioselective as well as enantioselective synthesis of an unsymmetric (C-1) chiral macrocycle from the reaction of an unsymmetric (C-1) chiral dialdehyde, (S)-4, that contains a salicylaldehyde unit and a benzaldehyde unit, with lysine, an unsymmetric (C-1) chiral diamine. The enantioselectivity is further enhanced in the presence of Zn2+. Compound (S)-4 in combination with Zn2+ is found to be a highly chemoselective as well as enantioselective fluorescent probe for lysine. It can be used to detect specific enantiomers of this amino acid.
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