Journal
ORGANIC LETTERS
Volume 25, Issue 40, Pages 7316-7321Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c02666
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A method for the contra-thermodynamic protection and thermodynamic deprotection of alcohols is reported, where all reagents are returned to their original state. This is achieved by using visible light photochemical energy to drive the formation of highly strained trans-(Z)-cyclohexene. The product ethers have more potential energy than the starting materials at STP, allowing them to be catalytically returned to the starting materials, effectively realizing a protection-deprotection scheme paid for with an energy currency.
We report herein a method for the contra-thermodynamic protection and thermodynamic deprotection of alcohols in which all reagents are returned to their original state. This is accomplished by the use of visible light photochemical energy to drive the formation of a highly strained trans-(Z)-cyclohexene. At STP the product ethers contain more potential energy than the starting materials and, thus, can be catalytically returned to the starting materials, effectively realizing a protection-deprotection scheme paid for with an energy currency.
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