4.8 Article

A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism

Related references

Note: Only part of the references are listed.
Article Neurosciences

Why Do So Many Drugs for Alzheimer's Disease Fail in Development? Time for New Methods and New Practices?

Robert E. Becker et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Article Biochemistry & Molecular Biology

NEDD4-mediated HSF1 degradation underlies α-synucleinopathy

Eunhee Kim et al.

HUMAN MOLECULAR GENETICS (2016)

Article Medicine, General & Internal

Frequency power and coherence of electroencephalography are correlated with the severity of Alzheimer's disease: A multicenter analysis in Taiwan

Chih-Chung Chen et al.

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION (2015)

Article Multidisciplinary Sciences

Hippocampal-prefrontal input supports spatial encoding in working memory

Timothy Spellman et al.

NATURE (2015)

Article Neurosciences

Frequency-specific hippocampal-prefrontal interactions during associative learning

Scott L. Brincat et al.

NATURE NEUROSCIENCE (2015)

Article Neurosciences

What does gamma coherence tell us about inter-regional neural communication?

Gyoergy Buzsaki et al.

NATURE NEUROSCIENCE (2015)

Review Behavioral Sciences

Hippocampal-cortical interaction in decision making

Jai Y. Yu et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2015)

Review Neurosciences

Rhythms for Cognition: Communication through Coherence

Pascal Fries

NEURON (2015)

Article Radiology, Nuclear Medicine & Medical Imaging

In vivo imaging of induction of heat-shock protein-70 gene expression with fluorescence reflectance imaging and intravital confocal microscopy following brain ischaemia in reporter mice

Xavier de la Rosa et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2013)

Article Clinical Neurology

Wavelet Coherence Model for Diagnosis of Alzheimer Disease

Ziad Sankari et al.

CLINICAL EEG AND NEUROSCIENCE (2012)

Review Neurosciences

Oscillations in the prefrontal cortex: a gateway to memory and attention

Karim Benchenane et al.

CURRENT OPINION IN NEUROBIOLOGY (2011)

Article Medicine, Research & Experimental

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

John Labbadia et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Review Neurosciences

Alzheimer's disease: synapses gone cold

Robert M. Koffie et al.

MOLECULAR NEURODEGENERATION (2011)

Review Biotechnology & Applied Microbiology

Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases

Daniel W. Neef et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

Article Neurosciences

Chronic Stress-induced Hippocampal Vulnerability: The Glucocorticoid Vulnerability Hypothesis

Cheryl D. Conrad

REVIEWS IN THE NEUROSCIENCES (2011)

Article Pharmacology & Pharmacy

Brain-Permeable Small-Molecule Inhibitors of Hsp90 Prevent α-Synuclein Oligomer Formation and Rescue α-Synuclein-Induced Toxicity

Preeti Putcha et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)

Review Neurosciences

Heat shock protein 90 in neurodegenerative diseases

Wenjie Luo et al.

MOLECULAR NEURODEGENERATION (2010)

Article Biochemical Research Methods

Thinned-skull cranial window technique for long-term imaging of the cortex in live mice

Guang Yang et al.

NATURE PROTOCOLS (2010)

Review Cell Biology

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

Mikko Taipale et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Review Neurosciences

Heat shock proteins: Cellular and molecular mechanisms in the central nervous system

R. Anne Stetler et al.

PROGRESS IN NEUROBIOLOGY (2010)

Review Neurosciences

Structural dynamics of dendritic spines in memory and cognition

Haruo Kasai et al.

TRENDS IN NEUROSCIENCES (2010)

Article Biochemistry & Molecular Biology

Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line

Yuanming Lu et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2009)

Article Chemistry, Medicinal

Synthesis of pochoxime prodrugs as potent HSP90 inhibitors

Cuihua Wang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

Article Biochemistry & Molecular Biology

Inhibition of HSP90 with Pochoximes: SAR and Structure-Based Insights

Sofia Barluenga et al.

CHEMBIOCHEM (2009)

Article Multidisciplinary Sciences

Stably maintained dendritic spines are associated with lifelong memories

Guang Yang et al.

NATURE (2009)

Article Biotechnology & Applied Microbiology

HSP70 and constitutively active HSF1 mediate protection against CDCrel-1-mediated toxicity

Alisha E. Jung et al.

MOLECULAR THERAPY (2008)

Article Multidisciplinary Sciences

Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies

Wenjie Luo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Chemistry, Medicinal

A non-toxic Hsp90 inhibitor protects neurons from Aβ-induced toxicity

Sabah Ansar et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

Article Medicine, Research & Experimental

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

Chad A. Dickey et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Review Oncology

HSP90 and the chaperoning of cancer

L Whitesell et al.

NATURE REVIEWS CANCER (2005)

Article Neurosciences

Hippocampal network patterns of activity in the mouse

G Buzsaki et al.

NEUROSCIENCE (2003)

Review Biochemistry & Molecular Biology

Hsp90 inhibitors as novel cancer chemotherapeutic agents

L Neckers

TRENDS IN MOLECULAR MEDICINE (2002)