Journal
MOLECULAR PLANT-MICROBE INTERACTIONS
Volume 29, Issue 3, Pages 165-169Publisher
AMER PHYTOPATHOLOGICAL SOC
DOI: 10.1094/MPMI-09-15-0212-FI
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Funding
- United States National Science Foundation, Integrative Organismal Systems award [1257869]
- National Institute of Food and Agriculture, U.S. Department of Agriculture [2012-67013-19396]
- China Scholarship Council
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1650843, 1257869] Funding Source: National Science Foundation
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Plant small RNAs play important roles in transcriptional and posttranscriptional regulation, with ongoing work demonstrating their functions in diverse pathways. Their roles in defense responses are a topic of active investigation, particularly the rich set of micro (mi)RNAs that target disease resistance genes such as nucleotide binding/leucine-rich repeat (NB-LRR) genes. The miRNA-NB-LRR interactions result in the production of phased, secondary small interfering (phasi)RNAs, and phasiRNAs function in both cis and trans to propagate negative regulatory effects across additional members of the target gene family. Yet, while phasiRNAs have the capacity to trigger targeted decay of specific targets, both in cis and trans, their functional relevance in NB-LRR regulation remains largely a matter of speculation.
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