4.8 Article

AKIP1 accelerates glioblastoma progression through stabilizing EGFR expression

Related references

Note: Only part of the references are listed.
Review Cell Biology

Pyroptosis, ferroptosis, and autophagy cross-talk in glioblastoma opens up new avenues for glioblastoma treatment

Sicheng Wan et al.

Summary: Glioma is a common and aggressive brain tumor, and understanding the complex regulatory network that allows cancer cells to evade death is crucial for effective treatment. This review summarizes recent advances in the molecular mechanisms of inducing or inhibiting pyroptosis, ferroptosis, or autophagy in glioblastoma multiforme (GBM), and discusses their links with apoptosis. These findings are important for developing new strategies to target these cell death pathways and improve treatment outcomes.

CELL COMMUNICATION AND SIGNALING (2023)

Article Multidisciplinary Sciences

Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy

Yazhe Wang et al.

Summary: In this study, we developed functionalized nanoparticles loaded with anti-seed s gamma PNAs to target oncomiRs 10b and 21 in tumor cells. Combined with temozolomide, these nanoparticles significantly improved the survival of orthotopic mouse models of GBM. This study provides a promising approach to personalized treatment of GBM based on tumor-specific oncomiRs.

SCIENCE ADVANCES (2023)

Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Review Oncology

Epigenetics of glioblastoma multiforme: From molecular mechanisms to therapeutic approaches

Md Sahab Uddin et al.

Summary: Research has shown that glioma progression is closely linked to different types of epigenetic phenomena, such as chromatin modifications, DNA methylation, chromatin remodeling, and aberrant microRNA. Targeting the genes and proteins that control these alterations can be an effective way to treat GBM. Treatment approaches include histone deacetylase inhibitors and DNA methyltransferase inhibitors.

SEMINARS IN CANCER BIOLOGY (2022)

Article Cell Biology

ZC3H15 promotes glioblastoma progression through regulating EGFR stability

Jianbing Hou et al.

Summary: ZC3H15, an overexpressed protein in GBM, promotes the proliferation, migration, invasion, and tumorigenesis of GBM cells by activating the EGFR signaling pathway. High expression of ZC3H15 is associated with poor patient survival.

CELL DEATH & DISEASE (2022)

Article Oncology

DAB2IP down-regulates HSP90AA1 to inhibit the malignant biological behaviors of colorectal cancer

Mengna Zhang et al.

Summary: This study investigates the role and mechanism of DAB2IP and HSP90AA1 in colorectal cancer (CRC). Loss of DAB2IP is associated with poor prognosis, while elevated expression of HSP90AA1 is associated with malignant behavior in CRC. Mechanistically, DAB2IP promotes apoptosis through the HSP90AA1/SRP9/ASK1/JNK signaling axis. These findings suggest that targeting both DAB2IP and HSP90AA1 may be an effective treatment strategy for CRC.

BMC CANCER (2022)

Article Chemistry, Medicinal

Exploring the Spike-hACE 2 Residue-Residue Interaction in Human Coronaviruses SARS-CoV-2, SARS-CoV, and HCoV-NL63

Jose X. Lima Neto et al.

Summary: This study analyzed the interactions between coronaviruses and human ACE-2 protein using quantum biochemistry techniques. The results revealed that the interaction between SARS-CoV-2 and ACE-2 is the strongest, providing valuable information for understanding the structural behavior of coronaviruses and developing antiviral therapeutics.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2022)

Review Oncology

Emerging therapies for glioblastoma: current state and future directions

Liang Rong et al.

Summary: Glioblastoma (GBM) is a common brain tumor with poor prognosis. Immunotherapy, including immune checkpoint blockade, CAR T cell therapy, oncolytic virotherapy, and vaccine therapy, has shown promising results in improving GBM outcomes. Techniques to overcome the blood-brain barrier for targeted delivery are also being tested. This article reviews the rationales for these therapies, potential novel agents, current status of trials, and discusses challenges and future perspectives in glioblastoma immuno-oncology.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Article Biochemistry & Molecular Biology

CBX3 accelerates the malignant progression of glioblastoma multiforme by stabilizing EGFR expression

Wen Peng et al.

Summary: CBX3, also known as HP1 gamma, is upregulated in glioblastoma multiforme (GBM) and promotes cell proliferation, invasion, and tumorigenesis. It regulates the malignant progression of GBM through an EGFR-dependent mechanism. CBX3 directly suppresses the transcriptional levels of PARK2 and STUB1, reducing the ubiquitination of EGFR.

ONCOGENE (2022)

Review Oncology

Heat Shock Proteins and HSF1 in Cancer

Anna M. Cyran et al.

Summary: The fitness of cells depends on the maintenance of protein homeostasis, which is achieved through the cooperative activities of protein chaperones and proteolytic machinery. In response to protein-damaging conditions, cells activate the heat-shock response (HSR) by upregulating a group of chaperones known as heat shock proteins (HSPs). Cancer cells, which experience high levels of proteotoxic stress, often upregulate major components of HSR, including HSF1 and individual HSPs. Elevated levels of HSPs and HSF1 are associated with drug resistance and poor clinical outcomes in various types of cancer. Targeting protein quality controls represents a promising approach for the treatment of human malignancies, as it can enhance the efficacy of standard and targeted chemotherapy as well as immune checkpoint inhibitors. In cancers with specific dependencies, HSR components can serve as alternative targets to oncogenic drivers that are difficult to drug.

FRONTIERS IN ONCOLOGY (2022)

Article Oncology

Cancer treatment and survivorship statistics, 2022

Kimberly D. Miller et al.

Summary: The number of cancer survivors in the United States is increasing due to population growth, aging, and improved detection and treatment. The most prevalent cancers are prostate, skin melanoma, and colon and rectum for males, and breast, uterine corpus, and thyroid for females. Treatment disparities exist, with Black patients being less likely to be diagnosed with early-stage cancer and having lower surgical receipt rates.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Article Immunology

Combined bulk RNA-seq and single-cell RNA-seq identifies a necroptosis-related prognostic signature associated with inhibitory immune microenvironment in glioma

Sicheng Wan et al.

Summary: This study investigates the role of necroptosis in glioma, constructs a necroptosis-related signature (NRS) for predicting prognosis, and explores the correlation between NRS and tumor immune environment, chemotherapy sensitivity, etc. Experimental and data analysis reveal the importance of necroptosis-related genes in glioma.

FRONTIERS IN IMMUNOLOGY (2022)

Article Biochemistry & Molecular Biology

SMARCE1 promotes neuroblastoma tumorigenesis through assisting MYCN-mediated transcriptional activation

Xiaosong Hu et al.

Summary: This study reveals the critical oncogenic role of SMARCE1 gene in neuroblastoma, particularly in cases with MYCN amplification. SMARCE1 interacts with MYCN to mediate transcriptional activation of downstream target genes, promoting neuroblastoma proliferation and tumorigenicity. These findings provide a new potential therapeutic target for neuroblastoma with 17q21-ter gain and MYCN amplification.

ONCOGENE (2022)

Review Pharmacology & Pharmacy

Natural HSP90 inhibitors as a potential therapeutic intervention in treating cancers: A comprehensive review

Hui Yi Liew et al.

Summary: This review analyzes the chemical and biological activities of natural Hsp90 inhibitors, discusses their efficacy in tumor models, and explores their pharmacodynamics and pharmacokinetics.

PHARMACOLOGICAL RESEARCH (2022)

Article Oncology

The role of A-kinase interacting protein 1 in regulating progression and stemness as well as indicating the prognosis in glioblastoma

Jingxia Tang et al.

Summary: AKIP1 regulates the malignant behaviors and stemness of GBM via regulating multiple carcinogenetic pathways.

TRANSLATIONAL ONCOLOGY (2022)

Article Oncology

HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway

Guanghui Zhang et al.

Summary: This study reveals the potential role of HECTD3 in glioblastoma, demonstrating that it interacts with PARP1 and regulates its polyubiquitination, leading to the stabilization of PARP1 expression. This has implications for the treatment of glioblastoma.

BRITISH JOURNAL OF CANCER (2022)

Article Chemistry, Medicinal

Recent advances in the development of EGFR degraders: PROTACs and LYTACs

Dawei Hong et al.

Summary: This article discusses the role of EGFR in tumor development, the development of EGFR inhibitors, and the problem of resistance. It also highlights the recent advances in using EGFR degraders to overcome resistance.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

Review Oncology

Dual EGFR-VEGF Pathway Inhibition: A Promising Strategy for Patients With EGFR-Mutant NSCLC

Xiuning Le et al.

Summary: The VEGF and EGFR pathways play crucial roles in EGFR-mutant NSCLC, and dual inhibition of these two pathways can significantly improve patient outcomes.

JOURNAL OF THORACIC ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

UniProt: the universal protein knowledgebase in 2021

Alex Bateman et al.

Summary: The UniProt Knowledgebase aims to provide users with a comprehensive, high-quality set of protein sequences annotated with functional information. Updates over the past two years have increased the number of sequences to approximately 190 million, with new methods to assess proteome completeness and quality. UniProtKB has responded to the COVID-19 pandemic by expertly curating relevant entries and making them rapidly available through a dedicated portal.

NUCLEIC ACIDS RESEARCH (2021)

Article Chemistry, Medicinal

Effective degradation of EGFRL858R+T790M mutant proteins by CRBN-based PROTACs through both proteosome and autophagy/lysosome degradation systems

Xiaojuan Qu et al.

Summary: PROTAC technology offers a promising strategy to target EGFR protein and overcome drug resistance in non-small cell lung cancer patients with EGFR mutations. The involvement of autophagy/lysosome system in PROTAC-mediated target protein degradation is demonstrated in this study, providing new insights into cancer treatment.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Multidisciplinary Sciences

FBXL2 counteracts Grp94 to destabilize EGFR and inhibit EGFR-driven NSCLC growth

Mengmeng Niu et al.

Summary: The study shows that FBXL2 targets EGFR and TKI-resistant mutants for degradation, which inhibits EGFR-driven NSCLC growth and TKI resistance.

NATURE COMMUNICATIONS (2021)

Article Oncology

Dehydrodiisoeugenol inhibits colorectal cancer growth by endoplasmic reticulum stress-induced autophagic pathways

Changhong Li et al.

Summary: DEH inhibits cell growth in colorectal cancer by arresting the cell cycle and inducing cellular autophagy. Additionally, it activates endoplasmic reticulum stress pathways, suggesting its potential as an anticancer agent by inhibiting autophagy.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Chemistry, Medicinal

Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP

Mengzhu Zheng et al.

Summary: Inspired by the success of dual-targeting drugs, the study combines the concept of PROTAC and dual targeting to design and synthesize dual PROTAC molecules, which can degrade two different targets simultaneously. Novel dual-targeting PROTAC molecules have been successfully prepared and demonstrated to degrade both EGFR and PARP in cancer cells, expanding the application of PROTAC method in drug discovery.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Multidisciplinary Sciences

Accurate prediction of protein structures and interactions using a three-track neural network

Minkyung Baek et al.

Summary: Through the three-track network, we achieved accuracies approaching those of DeepMind in CASP14, enabling rapid solution of challenging x-ray crystallography and cryo-electron microscopy structure modeling problems, and providing insights into the functions of proteins with currently unknown structure.

SCIENCE (2021)

Review Oncology

PROTACs: A novel strategy for cancer therapy

Jing Liu et al.

SEMINARS IN CANCER BIOLOGY (2020)

Article Biochemical Research Methods

The HDOCK server for integrated protein-protein docking

Yumeng Yan et al.

NATURE PROTOCOLS (2020)

Article Oncology

Lycorine hydrochloride inhibits cell proliferation and induces apoptosis through promoting FBXW7-MCL1 axis in gastric cancer

Chongyang Li et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Review Oncology

Molecular targeted therapy of glioblastoma

Emilie Le Rhun et al.

CANCER TREATMENT REVIEWS (2019)

Review Biochemistry & Molecular Biology

Hsp90 and Hsp70 chaperones: Collaborators in protein remodeling

Olivier Genest et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Review Biology

The heat-shock, or HSF1-mediated proteotoxic stress, response in cancer: from proteomic stability to oncogenesis

Chengkai Dai

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2018)

Article Biochemistry & Molecular Biology

YY1 promotes IL-6 expression in LPS-stimulated BV2 microglial cells by interacting with p65 to promote transcriptional activation of IL-6

Xin-Chun Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Review Medicine, Research & Experimental

Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor: Overview and current state of the art

Hassan Mellatyar et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Biochemistry & Molecular Biology

EGFR-TKIs resistance via EGFR-independent signaling pathways

Qian Liu et al.

MOLECULAR CANCER (2018)

Review Biochemistry & Molecular Biology

The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease

Abdullah Hoter et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Cell Biology

The HSP90 chaperone machinery

Florian H. Schopf et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Review Genetics & Heredity

Regulation and function of the human HSP90AA1 gene

Abbey D. Zuehlke et al.

Review Biochemistry & Molecular Biology

Hsp90 interaction with clients

G. Elif Karagoez et al.

TRENDS IN BIOCHEMICAL SCIENCES (2015)

Review Cell Biology

EGF receptor trafficking: consequences for signaling and cancer

Alejandra Tomas et al.

TRENDS IN CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

A-kinase-interacting Protein 1 (AKIP1) Acts as a Molecular Determinant of PKA in NF-κB Signaling

Nan Gao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

AKIP1 enhances NF-κB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65

Nan Gao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Review Chemistry, Multidisciplinary

GROMACS: Fast, flexible, and free

D Van der Spoel et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

A-kinase-interacting protein localizes protein kinase A in the nucleus

M Sastri et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)