Related references
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Article
Surgery
Kiminori Sugino et al.
Summary: Age is an important prognostic indicator for thyroid cancer. This study found that age, extrathyroidal extension, and numbers of metastatic lymph nodes are related to disease-specific survival and distant metastasis-free survival in papillary thyroid cancer (PTC) patients. Age does not significantly affect disease-free survival in patients without extrathyroidal extension. However, in patients with extrathyroidal extension, elderly patients have worse survival rates compared to young patients. Therefore, age should be considered when determining the surgical strategy for PTC patients.
WORLD JOURNAL OF SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Zheying Zhang et al.
Summary: We report a circRNA named hsa_Circ_0000826 (Circ_0000826) that is significantly downregulated in colorectal cancer (CRC) tissues and is associated with a poor prognosis in patients. Silencing Circ_0000826 promotes CRC cell proliferation, while overexpression of Circ_0000826 inhibits CRC cell proliferation. Furthermore, Circ_0000826 can bind to AUF1 and competitively inhibit its binding to c-MYC 30-UTR, leading to decreased c-MYC expression and cell proliferation.
JOURNAL OF GENETICS AND GENOMICS
(2023)
Article
Multidisciplinary Sciences
Shuang Chen et al.
Summary: This study identified circNEIL3 (hsa_circ_0001460) as a TGF beta-repressive and metastasis-related circRNA, which effectively inhibits tumor metastasis by directly interacting with onco-genic protein YBX1 and promoting its Nedd4L-mediated proteasomal degradation. The findings highlight the significance of circNEIL3 as a potential biomarker and therapeutic option in cancer treatment, and shed light on the molecular mechanism of circRNA in metastasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Oncology
Sisi Deng et al.
Summary: Circular RNA circARHGAP5 plays a role in cisplatin resistance in cervical squamous cell carcinoma (CSCC) by binding to AUF1 and preventing its interaction with BIM mRNA, leading to inhibition of apoptosis. This study provides insights into overcoming cisplatin resistance in CSCC.
Article
Biochemistry & Molecular Biology
Qinfang Liu et al.
Summary: This study identifies the role of the purine biosynthesis pathway enzyme ATIC in regulating LRRK2 protein levels and toxicity. The precursor AICAr can regulate LRRK2 levels in a cell-type-specific manner in vitro and in mouse tissue. AICAr regulates LRRK2 levels through AUF1-mediated mRNA decay. This study provides insights into a novel regulatory mechanism of LRRK2 protein levels and function, independent of its enzymatic activity.
Article
Otorhinolaryngology
Huy Gia Vuong et al.
Summary: This study reveals significant differences in metastatic patterns and survival among different subtypes of thyroid cancer.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Endocrinology & Metabolism
Hanning Li et al.
Summary: This study identified TSH receptor as a potential target for CAR-T therapy in differentiated thyroid cancer, showing high expression in various types of thyroid cancer. Using novel anti-TSHR CAR-T cells from monoclonal antibodies, significant anti-tumor activity was demonstrated in vitro, with K1-70 CAR-T cells showing therapeutic efficacy in vivo without apparent toxicity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cell Biology
Shuilian Wu et al.
Summary: Extensive research has confirmed that circRNA circGLIS3 plays an oncogene role in bladder cancer by affecting the proliferation, migration, and invasion of bladder cancer cells, as well as regulating cell cycle progression through the upregulation of cyclin D1 expression.
CELL BIOLOGY AND TOXICOLOGY
(2022)
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Biotechnology & Applied Microbiology
Chen Yang et al.
Summary: This study identified differentially expressed circRNAs in bladder cancer tissue and exosomes, and investigated their roles in cancer cell behavior and immune function. The findings revealed the regulatory function of exosome-derived circTRPS1 in BCa cells and provided potential therapeutic targets for BCa.
Review
Oncology
Lasse S. Kristensen et al.
Summary: Circular RNAs (circRNAs) are a novel class of primarily non-coding RNAs with increasingly recognized roles in cancer development and progression through diverse mechanisms of action. In this review, the authors summarize the current understanding of circRNA biogenesis, regulation, physiological functions and pathophysiological roles in cancer. They also discuss the clinical potential of circRNAs as biomarkers, therapeutic agents and drug targets in oncology, as well as the research controversies, technical issues, and biological knowledge gaps that need to be addressed.
NATURE REVIEWS CLINICAL ONCOLOGY
(2022)
Article
Pathology
Jun Liu et al.
Summary: The expression of CyclinD1 and D2-40 varies significantly in follicular neoplasm (FN) and other thyroid adenomatoid lesions, serving as helpful diagnostic markers to distinguish FN from other types of lesions.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Endocrinology & Metabolism
Uchechukwu C. C. Megwalu et al.
Summary: Thyroid cancer incidence rates have declined since 2014, with similar declines noted for papillary thyroid carcinoma (PTC), localized disease, and tumors <= 1.0 cm, but not for tumors >2.0 cm. Incidence-based mortality rates continue to increase. These findings suggest changes in the management of thyroid nodules may have led to a decrease in the diagnosis of small indolent tumors, but not more advanced tumors.
Review
Oncology
Douglas Hanahan
Summary: The concept of the hallmarks of cancer is a tool for simplifying the complexity of cancer phenotypes and genotypes into basic principles. This article proposes phenotypic plasticity and disrupted differentiation as distinct hallmark capabilities, and discusses nonmutational epigenetic reprogramming and polymorphic microbiomes as enabling characteristics. Additionally, the importance of senescent cells in the tumor microenvironment is highlighted. The integrative concept of the hallmarks of cancer helps in understanding the mechanisms of cancer development and applying that knowledge to cancer medicine.
Article
Cell Biology
Deguang Zhang et al.
Summary: In this study, circRNA high-throughput sequencing was used to identify alterations in circRNA expression levels in PTC tissues. circTIAM1 was found to be upregulated in PTC and associated with apoptosis, proliferation, and migration of PTC cells. Mechanistically, circTIAM1 acted as a sponge of microRNA-646 and functioned in PTC by targeting miR-646 and heterogeneous ribonucleoprotein A1. These findings highlight the oncogenic role of circTIAM1 in PTC and suggest its potential as a therapeutic target for PTC progression.
CELL DEATH DISCOVERY
(2022)
Review
Biochemistry & Molecular Biology
Chu-Xiao Liu et al.
Summary: In this review, we discuss the methods used in circular RNA studies and the current understanding of their regulatory roles and potential applications. Circular RNAs can modulate transcription and splicing, regulate the stability and translation of mRNAs, interfere with signaling pathways, and play important roles in cellular processes and immune responses.
Article
Cell Biology
Xinzhi Peng et al.
Summary: This study discovered that circRNA_0057209 can increase the expression of STK4 by competitively binding to miR-183 in thyroid cancer, thereby inhibiting tumor development. This finding is important for further understanding the pathogenesis of thyroid cancer and identifying new treatment approaches.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Reproductive Biology
Lijuan Hu et al.
Summary: The study found that hsa_circ_0011385 is up-regulated in cervical cancer and is related to miR-149-5p and PRDX6. Inhibiting hsa_circ_0011385 can reduce proliferation, metastasis, invasion, and angiogenesis of cervical cancer cells, while promoting apoptosis and cell cycle arrest. These findings suggest that hsa_circ_0011385 may be a therapeutic target for cervical cancer.
REPRODUCTIVE BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xuelin Yao et al.
Summary: Thyroid cancer is the leading cause of endocrine malignancies globally, with circRNAs playing crucial roles in tumourigenesis and progression, regulating cancer through diverse mechanisms and showing potential clinical applications.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Qiang Ma et al.
Summary: This study identified a novel circular RNA, circARID1A, that can bind to the IGF2BP3 protein. CircARID1A was significantly upregulated in gastric cancer tissues and positively correlated with tumor characteristics. Knocking down circARID1A inhibited the proliferation of gastric cancer cells. Mechanistically, circARID1A acted as a scaffold to facilitate the interaction between IGF2BP3 and SLC7A5 mRNA, thereby increasing the stability of SLC7A5 mRNA and promoting gastric cancer proliferation through the AKT/mTOR pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
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Medicine, Research & Experimental
Mengting Shao et al.
Summary: In this study, a non-negative matrix-factorization-based pipeline called CRIT was developed to identify the RNA-binding proteins that regulate circRNAs in cancers. They uncovered 73 novel regulators and validated their predictions by analyzing circRNA-RBP interactions. Additionally, they found that newly discovered RBPs are functionally connected with authentic circRNA regulators by various biological associations.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Endocrinology & Metabolism
Kamilla Schmitz Nunes et al.
Summary: This study found that male patients with radioiodine refractory disease and metastasis at multiple sites have a higher risk of death in metastatic PTC.
Article
Biochemical Research Methods
Siqi Li et al.
Summary: The study demonstrates that CRISPR-RfxCas13d can effectively discriminate circRNAs from mRNAs and has identified important circRNAs involved in cell growth, such as the pro-proliferative circFAM120A and the regulatory circMan1a2 in mouse embryo preimplantation development.
Article
Biochemistry & Molecular Biology
Dimitrios Tsitsipatis et al.
Summary: The study revealed the interaction between AUF1 and circPCNX, which can impact the production of p21 in cells and regulate cell proliferation. Eliminating the AUF1-binding region of circPCNX can abolish the increase in p21 levels and rescue proliferation.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biology
Lotte Victoria Winther Stagsted et al.
Summary: The study identified two factors, SFPQ and NONO, enriched around circRNA loci, particularly playing important roles in DALI circRNAs. Results indicate that SFPQ plays a crucial role in maintaining intron integrity, while also revealing novel features governing Alu-independent circRNA production.
Article
Cell Biology
Chuangye Ni et al.
Summary: This study found that high expression of circ_0011385 in HCC is closely associated with tumor size, TNM stage, and prognosis, and its inhibition can prevent proliferation of HCC cells. Circ_0011385 acts as a sponge for miR-361-3p, regulating the mRNA expression of STC2, with its transcription being regulated by SP3. Therefore, circ_0011385 may serve as a new biomarker for HCC.
CELL DEATH DISCOVERY
(2021)
Article
Cell Biology
Su-jin Yang et al.
Summary: This study reveals that circPSMA1 functions as a tumor promoter in triple-negative breast cancer (TNBC) by acting as a miRNA sponge to absorb miR-637 and regulate Akt1-beta-catenin (cyclin D1) axis. Exosomes from TNBC cells carrying high levels of circPSMA1 can transmit migration and proliferation capacity to recipient cells. High expression of Akt1 and low expression of miR-637 are highly correlated with poor prognosis in TNBC patients with lymph node metastasis.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Valerio Nardone et al.
Summary: The expanding clinical application of CDK4- and CDK6-inhibiting drugs in breast cancer has sparked interest in testing them in other tumors. Potential combinations with other therapeutic approaches are being explored, with some hypotheses about integrating CDK4 and CDK6 inhibitors with radiotherapy. However, more research is needed to further investigate the potential benefits of these combinations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Min Guo et al.
Summary: Circular RNAs (circRNAs) are a novel type of non-coding RNAs that show dysregulated expression in various tumorigeneses, including thyroid carcinoma. This study identified dysregulated circRNAs in papillary thyroid carcinoma patients, with one circRNA showing strong predictive power and interactions with cancer-related genes. Bioinformatics analyses revealed a potential interaction between hsa_circ_IPCEF1 and hsa-miR-3619-5p in PTC pathogenesis.
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