☆ 4.3 Article

Production, isolation, and shipment of clinically relevant quantities of astatine-211: A simple and efficient approach to increasing supply

NUCLEAR MEDICINE AND BIOLOGY (2023)

Related references

Note: Only part of the references are listed.

Article Engineering, Environmental

Mechanism of astatine and bismuth sorption on extraction chromatography resins from nitric acid media

Evgeny E. Tereshatov et al.

Summary: A systematic study on astatine (At) sorption on extraction chromatography resins from nitric acid media has been conducted at Texas A&M University. Commercially available resins such as LN, TK400, SR, TRU, and UTEVA were included in this study. Understanding the behavior of At in nitric acid solutions is crucial for the development of a fast and reliable separation and purification system. The results showed high distribution coefficients for all the studied resins, with TRU and UTEVA resins reaching values as high as 400. The sorption uptake followed the order: TRU ≥ UTEVA > TK400 ≥ SR > LN. Thermodynamic models were developed for each resin to suggest possible mechanisms of At sorption, and sorption constants were estimated. Additionally, a mathematical model was proposed to describe bismuth (Bi) sorption by the studied resins in nitric acid media, and separation factors of At and Bi were estimated using the ratio of fit functions assigned to the same resin and acidity. Only the TRU resin was found to be unsuitable for efficient At isolation from Bi, while the other four resins showed promising results.

CHEMICAL ENGINEERING JOURNAL (2023)

Add to Collection

Article Engineering, Chemical

Separation, speciation, and mechanism of astatine and bismuth extraction from nitric acid into 1-octanol and methyl anthranilate

Evgeny E. Tereshatov et al.

Summary: A detailed study has been conducted on the extraction of Bi and At from nitric acid media into conventional solvents, with a mathematical modeling used to fit experimental data and determine extraction and stability constants. A computational study was also performed to evaluate At interaction with the solvents.

SEPARATION AND PURIFICATION TECHNOLOGY (2022)

Add to Collection

Review Radiology, Nuclear Medicine & Medical Imaging

Harnessing α-Emitting Radionuclides for Therapy: Radiolabeling Method Review

Hua Yang et al.

Summary: Targeted alpha-therapy is a promising tool for treating late-stage cancers. By using targeted radiopharmaceuticals, tissue- or cell-specific delivery of a-emitters can be achieved. Researchers are currently focusing on developing effective stable chelators for a-emitters, but there are still challenges to overcome.

JOURNAL OF NUCLEAR MEDICINE (2022)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

An Improved 211At-Labeled Agent for PSMA-Targeted α-Therapy

Ronnie C. Mease et al.

Summary: This study synthesized a new radiotracer, At-211-3-Lu, for the treatment of PSMA-positive prostate cancer. The results showed that At-211-3-Lu had low toxicity, significant therapeutic effects, and no significant off-target toxicity.

JOURNAL OF NUCLEAR MEDICINE (2022)

Add to Collection

Article Engineering, Environmental

Compact automated apparatus for rapid astatine recovery from nitric acid media: Design, application, and impurity characterization

Evgeny E. Tereshatov et al.

Summary: Automation of irradiated bismuth target dissolution and astatine recovery has been achieved at Texas A&M University, resulting in fast and efficient separation of highly pure astatine.

CHEMICAL ENGINEERING JOURNAL (2022)

Add to Collection

Review Chemistry, Multidisciplinary

Recent progress of astatine-211 in endoradiotherapy: Great advances from fundamental properties to targeted radiopharmaceuticals

Feize Li et al.

Summary: Astatine-211 (At-211) is a promising alpha-emitter for targeted-alpha therapy (TAT) in various malignancies, due to its high linear energy transfer and short tissue range. In the past two decades, significant progress has been made in At-211-related radiopharmaceutical research, providing important insights for tumor radiotherapy and other radiopharmaceutical studies.

CHINESE CHEMICAL LETTERS (2022)

Add to Collection

Article Chemistry, Inorganic & Nuclear

Complexation of Astatine(III) with Ketones: Roles of NO3- Counterion and Exploration of Possible Binding Modes

Jonathan D. Burns et al.

Summary: Ketones have been proven effective in extracting astatine(III) from aqueous solvents. Co-extraction of NO3- as AtO(NO3).(O=CR1R2) species into the organic phase appears to be a key factor. Adjusting the electronic properties of ketones can enhance the bond strength between the ketone and AtO+ and increase the extraction of astatine into the organic phase. Extraction with diketones is dependent on the bridging distance between the two carbonyl moieties.

INORGANIC CHEMISTRY (2022)

Add to Collection

Article Chemistry, Inorganic & Nuclear

Astatine-211 labelled a small molecule peptide: specific cell killing in vitro and targeted therapy in a nude-mouse model

Weihao Liu et al.

Summary: The study demonstrates that At-211 labeled VP2 fusion peptide exhibits more effective cytotoxicity against malignant epithelial tumors in vitro and in vivo, leading to significant tumor growth inhibition and prolonged survival in mice.

RADIOCHIMICA ACTA (2021)

Add to Collection

Article Engineering, Chemical

Rapid recovery of At-211 by extraction chromatography

Jonathan D. Burns et al.

Summary: The near quantitative separation, purification, and recovery of At-211 has been demonstrated through a rapid extraction chromatography process, achieving elution yields of 92-95%. This represents a significant advance in At separations, with high purity At-211 recovered in near quantitative yields.

SEPARATION AND PURIFICATION TECHNOLOGY (2021)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

Production and supply of alpha particles emitting radionuclides for Targeted Alpha Therapy (TAT).

Valery Radchenko et al.

JOURNAL OF NUCLEAR MEDICINE (2021)

Add to Collection

Review Radiology, Nuclear Medicine & Medical Imaging

Production, purification and availability of 211At: Near term steps towards global access

Yutian Feng et al.

Summary: At-211 has promising characteristics for targeted alpha-particle therapy, with suitable chemical properties for labeling targeting vectors and emission of only one alpha-particle per decay. However, its impact is limited by availability constraints, despite utilizing a widely available natural material for production. The main impediment to wider availability is the need for specific accelerators capable of generating alpha-particles at clinically relevant levels.

NUCLEAR MEDICINE AND BIOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Synthesis of [211At]4-astato-L-phenylalanine by dihydroxyboryl-astatine substitution reaction in aqueous solution

Yoshifumi Shirakami et al.

Summary: A novel method for the synthesis of astatine-211-labeled phenylalanine was developed, resulting in high radiochemical yields and purity of the product, making it suitable for clinical applications.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Chemistry, Analytical

Measurements of the excitation functions of radon and astatine isotopes from 7Li-induced reactions with 209Bi for development of a 211Rn-211At generator

Eita Maeda et al.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY (2020)

Add to Collection

Article Chemistry, Inorganic & Nuclear

A Solid-State Support for Separating Astatine-211 from Bismuth

David H. Woen et al.

INORGANIC CHEMISTRY (2020)

Add to Collection

Article Chemistry, Inorganic & Nuclear

Questioning the Affinity of Electrophilic Astatine for Sulfur-containing Compounds: Unexpected Bindings Revealed

Fadel Bassal et al.

INORGANIC CHEMISTRY (2020)

Add to Collection

Article Chemistry, Analytical

Preparation of no-carrier-added211At solutions by a simple dry distillation method in the209Bi(4He, 2n)211At reaction

Ichiro Nishinaka et al.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Astatine partitioning between nitric acid and conventional solvents: indication of covalency in ketone complexation of AtO+

Jonathan D. Burns et al.

CHEMICAL COMMUNICATIONS (2020)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

PET Imaging of PARP Expression Using 18F-Olaparib

Thomas C. Wilson et al.

JOURNAL OF NUCLEAR MEDICINE (2019)

Add to Collection

Article Multidisciplinary Sciences

Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets

Matthew J. O'Hara et al.

SCIENTIFIC REPORTS (2019)

Add to Collection

Article Chemistry, Organic

Rapid Cu-Catalyzed [At-211]Astatination and [I-125]Iodination of Boronic Esters at Room Temperature

Sean W. Reilly et al.

ORGANIC LETTERS (2018)

Add to Collection

Review Pharmacology & Pharmacy

An Overview of Targeted Alpha Therapy with 225Actinium and 213Bismuth

Alfred Morgenstern et al.

CURRENT RADIOPHARMACEUTICALS (2018)

Add to Collection

Article Chemistry, Analytical

Extraction of 211At from nitric acid solutions into various organic solvents for use as an α-source for radiation chemistry studies

Christian Ekberg et al.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY (2017)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

Development of a preclinical 211Rn/211At generator system for targeted alpha therapy research with 211At

Jason R. Crawford et al.

NUCLEAR MEDICINE AND BIOLOGY (2017)

Add to Collection

Article Chemistry, Inorganic & Nuclear

An automated flow system incorporating in-line acid dissolution of bismuth metal from a cyclotron irradiated target assembly for use in the isolation of astatine-211

Matthew J. O'Hara et al.

APPLIED RADIATION AND ISOTOPES (2017)

Add to Collection

Article Chemistry, Inorganic & Nuclear

211Rn/211At and 209At production with intense mass separated Fr ion beams for preclinical 211At-based α-therapy research

Jason R. Crawford et al.

APPLIED RADIATION AND ISOTOPES (2017)

Add to Collection

Review Chemistry, Multidisciplinary

18F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography

Sean Preshlock et al.

CHEMICAL REVIEWS (2016)

Add to Collection

Article Multidisciplinary Sciences

Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

Emma Aneheim et al.

SCIENTIFIC REPORTS (2015)

Add to Collection

Article Oncology

The potential and hurdles of targeted alpha therapy - clinical trials and beyond

Jorgen Eigqvist et al.

FRONTIERS IN ONCOLOGY (2014)

Add to Collection

Article Oncology

Molecular Pathways: Targeted α-Particle Radiation Therapy

Kwamena E. Baidoo et al.

CLINICAL CANCER RESEARCH (2013)

Add to Collection

Article Chemistry, Multidisciplinary

Evaluation of a Wet Chemistry Method for Isolation of Cyclotron Produced [211At]Astatine

Ethan R. Balkin et al.

APPLIED SCIENCES-BASEL (2013)

Add to Collection

Article Pharmacology & Pharmacy

Astatine-211: Production and Availability

Michael R. Zalutsky et al.

CURRENT RADIOPHARMACEUTICALS (2011)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

Intraperitoneal α-Particle Radioimmunotherapy of Ovarian Cancer Patients: Pharmacokinetics and Dosimetry of 211At-MX35 F(ab′)2-A Phase I Study

Hakan Andersson et al.

JOURNAL OF NUCLEAR MEDICINE (2009)

Add to Collection

Article Chemistry, Inorganic & Nuclear

Extraction of astatine-211 in diisopropylether (DIPE)

C. Alliot et al.

RADIOCHIMICA ACTA (2009)

Add to Collection

Article Biochemical Research Methods

Feasibility of the radioastatination of a monoclonal antibody with astatine-211 purified by wet extraction

Mickael Bourgeois et al.

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS (2008)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

Clinical experience with alpha-particle-emitting At-211: Treatment of recurrent brain tumor patients with At-211-labeled chimeric antitenascin monoclonal antibody 81C6

Michael R. Zalutsky et al.

JOURNAL OF NUCLEAR MEDICINE (2008)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

Targeted α-particle radiotherapy with 211At-labeled monoclonal antibodies

Michael R. Zalutsky et al.

NUCLEAR MEDICINE AND BIOLOGY (2007)

Add to Collection

Article Chemistry, Organic

Simple, efficient catalyst system for the palladium-catalyzed amination of aryl chlorides, bromides, and triflates

JP Wolfe et al.

JOURNAL OF ORGANIC CHEMISTRY (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.