Journal
MOLECULAR PHARMACEUTICS
Volume 14, Issue 1, Pages 124-134Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.6b00753
Keywords
biodistribution; drug delivery; ICP-MS; nanoparticle; titanium; drug development
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Fluorescent poly(e-caprolactone)-based nano-particles (NPs) have been synthesized and successfully loaded with a titanium organometallic compound as a mimic of a water-insoluble drug. The nature of this nanovector enabled us to combine the quantification of the metal in tissues after systemic administration in healthy immunocompetent mice by inductively coupled plasma mass spectroscopy (ICP-MS) followed by the visualization of NPs in organ sections by confocal microscopy. This innovative method of nanodrug screening has enabled us to elucidate the crucial parameters of their kinetics. The organometallic compound is a good mimic of most anticancer drugs, and this approach is an interesting starting point to design the relevance of a broad range of nanoformulations in terms of safety and targeted delivery of the cargoes.
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