4.4 Article

Genome-wide identification of m6A-associated single nucleotide polymorphisms in complex diseases of nervous system

Related references

Note: Only part of the references are listed.
Review Endocrinology & Metabolism

Neurodegenerative Disorders of Alzheimer, Parkinsonism, Amyotrophic Lateral Sclerosis and Multiple Sclerosis: An Early Diagnostic Approach for Precision Treatment

Nishit Pathak et al.

Summary: Neurodegenerative diseases (NDs) are characterized by progressive dysfunction of synapses, neurons, glial cells, and their networks. These diseases can be classified based on clinical features, anatomic distribution of neurodegeneration, or principal molecular abnormalities. Abnormal protein conformers in these diseases may spread through interconnected neuronal pathways, contributing to specific anatomical patterns. Although the exact cause of NDs is still largely unknown, potential biomarker candidates have been identified for early detection and progression monitoring.

METABOLIC BRAIN DISEASE (2022)

Article Clinical Neurology

Analysis of high-risk pedigrees identifies 12 candidate variants for Alzheimer's disease

Craig C. Teerlink et al.

Summary: Analysis of high-risk pedigrees can effectively detect rare predisposition variants, with potential AD risk genes identified such as ABCA7 and TTR, as well as further validation of NOTCH3 variants. The study prioritizes seven additional candidate variants for further investigation.

ALZHEIMERS & DEMENTIA (2022)

Article Immunology

The Shared Mechanism and Candidate Drugs of Multiple Sclerosis and Sjogren's Syndrome Analyzed by Bioinformatics Based on GWAS and Transcriptome Data

Xiangxiang Hong et al.

Summary: This study explored the shared mechanism and candidate drugs of MS and SS, identifying JAK-STAT signaling pathway as a vital role and potential therapies for their comorbidity.

FRONTIERS IN IMMUNOLOGY (2022)

Article Biochemical Research Methods

M6A2Target: a comprehensive database for targets of m6A writers, erasers and readers

Shuang Deng et al.

Summary: N-6-methyladenosine (m(6)A) is the most abundant posttranscriptional modification in mammalian mRNA molecules, playing a crucial role. The m(6)A modification is a dynamic and reversible process regulated by a series of writers, erasers, and readers (WERs). Identification of the targets of WERs is particularly important for understanding this dynamic modification.

BRIEFINGS IN BIOINFORMATICS (2021)

Article Neurosciences

Association of HLA-DRB1, DQA1 and DQB1 alleles and haplotype in Parkinson's disease from South India

Sasiharan Pandi et al.

Summary: The study identified specific HLA alleles that may be associated with susceptibility and protection against Parkinson's disease.

NEUROSCIENCE LETTERS (2021)

Review Immunology

Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer's disease

Rishika Dhapola et al.

Summary: Alzheimer's disease (AD) is characterized by neuroinflammation, with cytokines and inflammatory molecules playing key roles in the generation of A beta and exacerbation of inflammation. Targeting pathways involved in microglial activation and promoting mitophagy may provide novel therapeutic options for the treatment of AD.

INFLAMMOPHARMACOLOGY (2021)

Review Neurosciences

Regulatory Mechanisms of the RNA Modification m6A and Significance in Brain Function in Health and Disease

Justine Mathoux et al.

Summary: RNA modifications, particularly N-6-methyladenosine (m(6)A), play a crucial role in regulating RNA functionality. m(6)A, the most abundant and well-studied RNA modification, is involved in regulating mRNA stability, microRNA processing, tRNA function, and plays a key role in neuronal development and function in the brain. Aberrant m(6)A signaling has been linked to neurological diseases such as Schizophrenia and Alzheimer's, highlighting its potential as a novel therapeutic target.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

Review Chemistry, Medicinal

Parkinson's Disease: A Review from Pathophysiology to Treatment

Bianca L. B. Marino et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2020)

Review Neurosciences

The m(6)A epitranscriptome: transcriptome plasticity in brain development and function

Ido Livneh et al.

NATURE REVIEWS NEUROSCIENCE (2020)

Article Multidisciplinary Sciences

Integrated Analysis of Whole Exome Sequencing and Copy Number Evaluation in Parkinson's Disease

Eman Al Yemni et al.

SCIENTIFIC REPORTS (2019)

Article Biochemistry & Molecular Biology

m6AVar: a database of functional variants involved in m6A modification

Yueyuan Zheng et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response

Jun Zhou et al.

MOLECULAR CELL (2018)

Editorial Material Clinical Neurology

The Parkinson Pandemic-A Call to Action

E. Ray Dorsey et al.

JAMA NEUROLOGY (2018)

Review Multidisciplinary Sciences

RNA modifications modulate gene expression during development

Michaela Frye et al.

SCIENCE (2018)

Review Cell Biology

Autophagy in neurodegenerative diseases: From pathogenic dysfunction to therapeutic modulation

Marta Martinez-Vicente

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2015)