Folic acid supplementation improved nicotine withdrawal-induced of memory loss via affecting oxidative status, inflammatory response, cholinergic activity, BDNF and amyloid-B in adolescent male rat

Article Pediatrics

Effect of Vitamin C Supplementation for Pregnant Smokers on Offspring Airway Function and Wheeze at Age 5 Years Follow-up of a Randomized Clinical Trial

Cindy T. McEvoy et al.

Summary: This study aimed to assess whether vitamin C supplementation in pregnant smokers is associated with increased and/or improved airway function in their offspring at age 5 years and whether vitamin C decreases the occurrence of wheeze.

JAMA PEDIATRICS (2023)

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Article Medicine, General & Internal

Association of Changes in Smoking Intensity With Risk of Dementia in Korea

Su-Min Jeong et al.

Summary: The study found that smoking cessation is associated with a lower risk of dementia, while reducing smoking intensity is associated with a higher risk. The results emphasize the importance of smoking cessation in reducing the disease burden of dementia.

JAMA NETWORK OPEN (2023)

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Article Pharmacology & Pharmacy

Omega-3 fatty acids prevent nicotine withdrawal-induced exacerbation of anxiety and depression by affecting oxidative stress balance, inflammatory response, BDNF and serotonin metabolism in rats

Ghulam Yahya Amiry et al.

Summary: In this study, we investigated the effects of adolescent nicotine exposure and subsequent abstinence on anxiety and depressive behaviors in rats. Nicotine withdrawal exacerbated anxiety behaviors through changes in oxidative stress balance, inflammatory response, and serotonin metabolism. Omega-3 fatty acid pre-treatment significantly prevented nicotine withdrawal-induced complications by restoring the mentioned biochemical changes. Overall, we suggest omega-3 fatty acid supplementation as a safe, inexpensive, and effective strategy for preventing or ameliorating detrimental effects caused by nicotine withdrawal at the cellular and behavioral levels.

EUROPEAN JOURNAL OF PHARMACOLOGY (2023)

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Article Nutrition & Dietetics

Association of folate intake with cardiovascular-disease mortality and all-cause mortality among people at high risk of cardiovascular-disease

Xiaoqing Xu et al.

Summary: This study examined the association between folate intake and CVD mortality and all-cause mortality. The results showed that moderate folate intake was associated with a lower risk of CVD mortality and all-cause mortality, while excessive folic acid supplementation may increase the risk of death.

CLINICAL NUTRITION (2022)

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Article Clinical Neurology

How prevalent and severe is addiction on GABAmimetic drugs in an elderly German general hospital population? Focus on gabapentinoids, benzodiazepines, and z-hypnotic drugs

Udo Bonnet et al.

Summary: The study compared the abuse and dependence of GPT, BDZ, and ZD in an elderly population, finding that GPT dependence was usually mixed with other substance dependencies, while the pure dependence on BDZ and ZD was more common.

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2022)

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Review Developmental Biology

Neurological repercussions of neonatal nicotine exposure: A review

Joyal Xavier et al.

Summary: Smoking during pregnancy increases the risk of SIDS and affects neurodevelopment, potentially leading to depression, learning difficulties, and behavioral disorders. Prenatal nicotine exposure alters neurotransmitter pathways and increases fetal susceptibility to nicotine.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2022)

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Article Psychiatry

Choline, folic acid, Vitamin D, and fetal brain development in the psychosis spectrum

Robert Freedman et al.

Summary: Choline, folic acid, and Vitamin D are essential for fetal brain development. Micronutrient deficiencies are associated with changes in brain development and increased incidence of psychiatric disorders. Micronutrient supplements can prevent deficiency and positively affect brain development, potentially decreasing the risk of future psychotic disorders.

SCHIZOPHRENIA RESEARCH (2022)

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Review Neurosciences

Biological determinants impact the neurovascular toxicity of nicotine and tobacco smoke: A pharmacokinetic and pharmacodynamics perspective

Sabrina Rahman Archie et al.

Summary: The detrimental effects of nicotine on the central nervous system are caused by its neurotoxic role on blood-brain barrier permeability, nicotinic acetylcholine receptor expression, and the dopaminergic system. Sex and age are important biological determinants that can affect the pharmacokinetics and pharmacodynamics of nicotine. Understanding the impact of sex and age on nicotine-induced neurotoxicity can help develop personalized treatment strategies for mitigating the harmful effects of nicotine.

NEUROTOXICOLOGY (2022)

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Review Nutrition & Dietetics

Evaluation of the association between maternal folic acid supplementation and the risk of congenital heart disease: a systematic review and meta-analysis

Zhengpei Cheng et al.

Summary: The study found that maternal FA supplementation is associated with a decreased risk of CHD. However, there is high heterogeneity in the association between FA supplementation and CHD, and high-dose FA intake may be positively associated with atrial septal defect.

NUTRITION JOURNAL (2022)

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Article Medicine, General & Internal

Tobacco and nicotine use

Bernard Le Foll et al.

Summary: This article provides insight into tobacco use and its related issues, including epidemiology, mechanisms, diagnosis, management, and impact on quality of life. Nicotine in tobacco affects the brain and causes addiction, with effective interventions such as psychosocial and pharmacological approaches available. Further research and development of novel interventions are essential.

NATURE REVIEWS DISEASE PRIMERS (2022)

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Review Geriatrics & Gerontology

Does folic acid supplementation have a positive effect on improving memory? A systematic review and meta-analysis of randomized controlled trials

Camellia Akhgarjand et al.

Summary: The results of this systematic review and meta-analysis suggest that overall folic acid supplementation does not significantly affect memory scores. However, subgroup analyses indicate that supplementation with folic acid may have favorable effects on memory levels under certain conditions, such as lower doses, longer treatment duration, conducted in eastern countries, and in participants equal to or older than 70 years old.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Article Medicine, General & Internal

Tobacco Addiction

Peter Selby et al.

Summary: A 58-year-old female smoker with multiple comorbidities and a history of major depression seeks treatment for smoking cessation. Despite using nicotine gum for 4 weeks continuously, she has been unable to quit smoking.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Behavioral Sciences

Inbred mouse strain differences in alcohol and nicotine addiction-related phenotypes from adolescence to adulthood

Laurel R. Seemiller et al.

Summary: Understanding the genetic basis of nicotine and alcohol use predisposition is crucial for public health efforts, as genetic contributions may vary with age. Animal models allow the study of genetic background and age effects on drug-related behaviors, controlling important variables like drug exposure. Inbred mouse lines have shown genetic contributions to nicotine and alcohol addiction-related behaviors. This review summarizes the differences in these behaviors across inbred mouse strains and discusses their changes from adolescence to adulthood.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2022)

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Article Geriatrics & Gerontology

Coenzyme Q10 ameliorates aging-induced memory deficits via modulation of apoptosis, oxidative stress, and mitophagy in aged rats

Leila Hosseini et al.

Summary: This study aimed to investigate the effects of Coenzyme Q10 (Q10) on memory impairment, oxidative stress, apoptosis, and mitophagy in aged rats. The findings showed that Q10 reversed aging-induced memory impairment and had therapeutic potential in aging-related memory decline.

EXPERIMENTAL GERONTOLOGY (2022)

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Review Oncology

Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention

Stephen S. Hecht et al.

Summary: Tobacco products containing nicotine and carcinogens are highly detrimental, causing millions of cancer deaths worldwide annually. The presence of multiple carcinogens in both smokeless tobacco products and cigarettes can now be assessed using biomarkers, which can help identify individuals at highest risk of developing tobacco-related cancer. Regulating the levels of carcinogens and nicotine in tobacco products, coupled with evidence-based tobacco control efforts, are recognized as effective pathways to prevent tobacco-related cancer.

NATURE REVIEWS CANCER (2022)

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Article Neurosciences

BDNF and nicotine dependence: associations and potential mechanisms

Zeyi Huang et al.

Summary: Smoking, a major preventable cause of death worldwide, is associated with nicotine addiction, which is considered a serious public health issue. The brain-derived neurotrophic factor (BDNF) plays a crucial role in nicotine dependence, as its expression in the brain is affected by nicotine.

REVIEWS IN THE NEUROSCIENCES (2021)

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Article Nutrition & Dietetics

Folic acid ameliorates neonatal isolation-induced autistic like behaviors in rats: epigenetic modifications of BDNF and GFAP promotors

Omyma G. Ahmed et al.

Summary: The study found that neonatal isolation in rats can induce autistic-like behaviors, which are associated with hypomethylation of BDNF and GFAP genes, increased oxidative stress, and other factors. Folic acid supplementation can reverse these effects.

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM (2021)

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Article Behavioral Sciences

Delayed voluntary physical exercise restores when and where object recognition memory after traumatic brain injury

Laura Martinez-Drudis et al.

Summary: Physical exercise can reduce memory deficits after traumatic brain injury, particularly in episodic-like memory tasks related to object recognition. This effect is associated with increased levels of BDNF in the hippocampus and the restoration of temporal order memory.

BEHAVIOURAL BRAIN RESEARCH (2021)

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Article Endocrinology & Metabolism

Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats

Sabiheh Amirahmadi et al.

Summary: This study demonstrated that folic acid could improve learning and memory ability in hypothyroid rats, possibly through regulating oxidative stress and AChE activity.

METABOLIC BRAIN DISEASE (2021)

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Article Neurosciences

Lacidipine Attenuates Symptoms of Nicotine Withdrawal in Mice

Kunal Khurana et al.

Summary: Nicotine withdrawal in mice leads to an increase in oxidative stress and various symptoms, which can be alleviated by lacidipine to restore normal behavior and reduce the effects of oxidative stress.

NEUROTOXICITY RESEARCH (2021)

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Article Neurosciences

Ceftriaxone Reduces Waterpipe Tobacco Smoke Withdrawal-induced Anxiety in rats via Modulating the Expression of TNF-a/NFB, Nrf2, and GLT-1

Alaa M. Hammad et al.

Summary: Exposure to waterpipe tobacco smoke was found to increase neuroinflammation and alter glutamate transport expression, leading to increased anxiety-like behavior. Treatment with ceftriaxone attenuated these effects.

NEUROSCIENCE (2021)

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Article Pharmacology & Pharmacy

Beneficial effects of vitamin D on anxiety and depression-like behaviors induced by unpredictable chronic mild stress by suppression of brain oxidative stress and neuroinflammation in rats

Hossein Bakhtiari-Dovvombaygi et al.

Summary: The study demonstrated that vitamin D can protect rats from anxiety and depression-like behaviors induced by chronic mild stress by reducing brain oxidative stress and inhibiting neuroinflammation.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2021)

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Article Behavioral Sciences

Behavioral Profiling in Early Adolescence and Early Adulthood of Male Wistar Rats After Short and Prolonged Maternal Separation

Stina Lundberg et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2020)

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Article Medicine, Research & Experimental

Effect of 4-Fluoro-N-(4-sulfamoylbenzyl) Benzene Sulfonamide on cognitive deficits and hippocampal plasticity during nicotine withdrawal in rats

Naeem Ur Rehman et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Plant Sciences

Effects of Hippeastrum reticulatum on memory, spatial learning and object recognition in a scopolamine-induced animal model of Alzheimer's disease

Trang Huyen Xuan Hoang et al.

PHARMACEUTICAL BIOLOGY (2020)

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Article Geriatrics & Gerontology

Exploratory and locomotor activity, learning and memory functions in somatostatin receptor subtype 4 gene-deficient mice in relation to aging and sex

Nikolett Szentes et al.

GEROSCIENCE (2019)

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Article Immunology

Anti-inflammatory agents for smoking cessation? Focus on cognitive deficits associated with nicotine withdrawal in male mice

Rocio Saravia et al.

BRAIN BEHAVIOR AND IMMUNITY (2019)

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Article Environmental Sciences

The effect of Zataria multiflora on pulmonary function tests, hematological and oxidant/antioxidant parameters in sulfur mustard exposed veterans, a randomized doubled-blind clinical trial

Mohammad Reza Khazdair et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2018)

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Review Neurosciences

Brain derived neurotrophic factor (BDNF), its tyrosine kinase receptor B (TrkB) and nicotine

Rita Machaalani et al.

NEUROTOXICOLOGY (2018)

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Article Dentistry, Oral Surgery & Medicine

Assessment of interleukin-1, interleukin-6, and tumor necrosis factor- levels in the peri-implant sulcular fluid among waterpipe (narghile) smokers and never-smokers with peri-implantitis

Tariq Abduljabbar et al.

CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH (2018)

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Article Chemistry, Multidisciplinary

Beneficial effects of garlic on learning and memory deficits and brain tissue damages induced by lead exposure during juvenile rat growth is comparable to the effect of ascorbic acid

Simagol Ghasemi et al.

DRUG AND CHEMICAL TOXICOLOGY (2017)

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Review Neurosciences

New mechanisms and perspectives in nicotine withdrawal

K. J. Jackson et al.

NEUROPHARMACOLOGY (2015)

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Article Biochemistry & Molecular Biology

Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self-administration and reinstatement of nicotine seeking in rats

Blake A. Kimmey et al.

ADDICTION BIOLOGY (2014)

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Article Substance Abuse

Cognitive effects of the acetylcholinesterase inhibitor, donepezil, in healthy, non-treatment seeking smokers: A pilot feasibility study

Rebecca L. Ashare et al.

DRUG AND ALCOHOL DEPENDENCE (2012)

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Article Clinical Neurology

Immune system inflammation in cocaine dependent individuals: implications for medications development

Helen C. Fox et al.

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2012)

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Article Neurosciences

The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation

Thomas J. Gould et al.

NEUROPHARMACOLOGY (2012)

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Article Neurosciences

Galantamine, an Acetylcholinesterase Inhibitor and Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors, Attenuates Nicotine Taking and Seeking in Rats

Thomas J. Hopkins et al.

NEUROPSYCHOPHARMACOLOGY (2012)

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Review Pharmacology & Pharmacy

Mechanistic insights into nicotine withdrawal

Michael Paolini et al.

BIOCHEMICAL PHARMACOLOGY (2011)

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Article Environmental Sciences

Oxidative stress and anxiety-like symptoms related to withdrawal of passive cigarette smoke in mice: Beneficial effects of pecan nut shells extract, a by-product of the nut industry

P. Reckziegel et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2011)

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Article Nutrition & Dietetics

Vernonia cinerea Less. supplementation and strenuous exercise reduce smoking rate: relation to oxidative stress status and beta-endorphin release in active smokers

Donrawee Leelarungrayub et al.

JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION (2010)

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Article Neurosciences

Changes in plasma brain-derived neurotrophic factor levels in smokers after smoking cessation

Soo-Young Bhang et al.

NEUROSCIENCE LETTERS (2010)

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Article Plant Sciences

Serotonin mediates beneficial effects of Hypericum perforatum on nicotine withdrawal signs

C. Mannucci et al.

PHYTOMEDICINE (2007)

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Article Neurosciences

Increased plasma brain-derived neurotrophic factor levels in chronic smokers following unaided smoking cessation

Tae-Suk Kim et al.

NEUROSCIENCE LETTERS (2007)

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Article Biochemical Research Methods

Morris water maze: procedures for assessing spatial and related forms of learning and memory

Charles V. Vorhees et al.

NATURE PROTOCOLS (2006)

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Article Endocrinology & Metabolism

Serum concentrations of nitric oxide, tumor necrosis factor (TNF)-α and TNF soluble receptors in women with overweight and obesity

M Olszanecka-Glinianowicz et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2004)

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Article Geriatrics & Gerontology

Folic acid supplementation in dementia: A preliminary report

BR Sommer et al.

JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY (2003)

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Review Chemistry, Analytical

Measurement of nitric oxide production in biological systems by using Griess Reaction assay

J Sun et al.

SENSORS (2003)

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Article Biochemistry & Molecular Biology

Effects of cigarette smoking with different tar content on erythrocyte oxidant/antioxidant status

I Durak et al.

ADDICTION BIOLOGY (2002)

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Folic acid supplementation improved nicotine withdrawal-induced of memory loss via affecting oxidative status, inflammatory response, cholinergic activity, BDNF and amyloid-B in adolescent male rat

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