Dosage matters: Uncovering the optimal duration of pain neuroscience education to improve psychosocial variables in chronic musculoskeletal pain. A systematic review and meta-analysis with moderator analysis

The aim was to examine the moderator effect of duration of PNE (total minutes) on changes in psychosocial variables after treatment in people with chronic musculoskeletal pain. PubMed/MEDLINE, Embase, Web of Science, Scopus and CINHAL databases were systematically searched from inception to 6 February 2023. A mixed-effects meta-regression was performed to determine the moderator effect of PNE duration. Twenty-three studies involving 2352 patients were included. Meta-analysis revealed a statistically significant effect in favour of PNE on pain neurophysiology knowledge, anxiety symptoms, catastrophizing and kinesi-ophobia. The total duration of PNE ranged from 40 to 720 min. A linear relationship was observed between longer duration of PNE (total minutes) and changes of psychosocial variables. In addition, a dose of 100, 200 and 400 min of PNE was estimated to exceed the minimum clinically important difference described in the literature for kinesiophobia (mean difference = -8.53 points), anxiety symptoms (mean difference = -1.88 points) and catastrophizing (mean difference = -7.17 points). Clinicians should provide a more tailored PNE to address psychosocial variables.

Automated summary

The aim of this study was to examine the moderator effect of duration of pain neuroscience education (PNE) on changes in psychosocial variables in patients with chronic musculoskeletal pain. A meta-analysis of 23 studies involving 2352 patients showed that longer duration of PNE had a significant effect on pain neurophysiology knowledge, anxiety symptoms, catastrophizing, and kinesiophobia. Additionally, a dose of 100, 200, and 400 minutes of PNE was estimated to exceed the minimum clinically important difference for kinesiophobia, anxiety symptoms, and catastrophizing.