Comparison of Oncogenes, Tumor Suppressors, and MicroRNAs Between Schizophrenia and Glioma: The Balance of Power

The risk of cancer in schizophrenia has been controversial. Confounders of the issue are cigarette smoking in schizophrenia, and antiproliferative effects of antipsychotic medications. The author has previously suggested comparison of a specific cancer like glioma to schizophrenia might help determine a more accurate relationship between cancer and schizophrenia. To accomplish this goal, the author performed three comparisons of data; the first a comparison of conventional tumor suppressors and oncogenes between schizophrenia and cancer including glioma. This comparison determined schizophrenia has both tumor-suppressive and tumor-promoting characteristics. A second, larger comparison between brain-expressed microRNAs in schizophrenia with their expression in glioma was then performed. This identified a core carcinogenic group of miRNAs in schizophrenia offset by a larger group of tumor-suppressive miRNAs. This proposed balance of power between oncogenes and tumor suppressors could cause neuroinflammation. This was assessed by a third comparison between schizo-phrenia, glioma and inflammation in asbestos-related lung cancer and mesothelioma (ALRCM). This revealed that schizophrenia shares more oncogenic similarity to ALRCM than glioma.

Automated summary

The risk of cancer in schizophrenia has been debated, with confounders such as smoking and antipsychotic medications. In this study, the author compared schizophrenia with cancer and found that both tumor-suppressive and tumor-promoting characteristics exist in schizophrenia. Additionally, schizophrenia shares more oncogenic similarity with asbestos-related lung cancer and mesothelioma.