Uncovering the link between air pollution and neurodevelopmental alterations during pregnancy and early life exposure: A systematic review

Air pollution plays, nowadays, a huge role in human's health and in the personal economy. Moreover, there has been a rise in the prevalence of neurodevelopmental disorders like the Autism Spectrum Disorder (ASD) in recent years. Current scientific studies have established a link between prenatal or perinatal exposure to environmental pollutants and ASD. This systematic review summarizes the current literature available about the relationship between exposure to air pollutants (particulate matter [PM], Second Organic Aerosols [SOA], Diesel Exhaust [DE], and Traffic Related Air Pollution [TRAP]) and neurodevelopmental disorders in preclinical models using rats and mice. The articles were selected and filtered using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology, and bias-evaluated using the SYstematic Review Centre for Labo-ratory animal Experimentation (SYRCLE) tool. Overall, our findings suggest that air pollutants are associated with negative developmental outcomes characterized by ASD-like behaviors, abnormal biochemical patterns, and impaired achievement of developmental milestones in rodents. However, there is not sufficient information in certain domains to establish a clear relationship. Short phrases for indexing terms: Air pollution affects neurodevelopment; PM exposure modifies glutamate system; Prenatal exposure combined with postnatal affect more to behavioral / cognitive domain; Air pollution modifies social behavior in rodents; Cognitive deficits can be detected after gestational exposure to air pollution.

Automated summary

Air pollution has a significant impact on human health and the economy, and there has been an increase in neurodevelopmental disorders like Autism Spectrum Disorder (ASD) in recent years. Studies have found a connection between prenatal or perinatal exposure to environmental pollutants and ASD. This systematic review analyzes current literature on the relationship between exposure to air pollutants and neurodevelopmental disorders in rodents, highlighting negative developmental outcomes related to ASD-like behaviors. However, more research is needed to establish a clear relationship in certain domains.