4.5 Article

5-HT6 Receptors Control GABAergic Transmission and CA1 Pyramidal Cell Output of Dorsal Hippocampus

Related references

Note: Only part of the references are listed.
Article Neurosciences

Spatiotemporal dynamics of 5-HT6 receptor ciliary localization during mouse brain development

Vincent Dupuy et al.

Summary: This study demonstrates the expression and localization of serotonin 5-HT6 receptor (5-HT6R) in the mouse brain at different developmental stages. The receptor is found in various brain regions during early development and is preferentially expressed in specific neuron types and astrocytes in adulthood. The localization of the receptor changes during neonatal stages, suggesting its involvement in neuronal differentiation and psychiatric disorders of neurodevelopmental origin.

NEUROBIOLOGY OF DISEASE (2023)

Article Biochemistry & Molecular Biology

A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility

Shu-Hsien Sheu et al.

Summary: This study discovers the existence of synapses between axons and primary cilia and reveals their role in neuronal communication. The cilia are enriched in serotonin receptors and can be stimulated by serotonin released from axons, altering the epigenetic state of the postsynaptic neuron.
Article Cell Biology

Probing the polarity of spontaneous perisomatic GABAergic synaptic transmission in the mouse CA3 circuit in vivo

Olivier Dubanet et al.

Summary: Researchers used non-invasive extracellular recording to investigate the function of GABA and found limited involvement of excitatory GABA in two specific models of epileptogenesis in the mouse CA3 circuit. However, this does not rule out its expression in other brain areas or pathological conditions. This method provides a promising tool for studying the impact of excitatory GABA in different pathological conditions affecting the hippocampal circuit.

CELL REPORTS (2021)

Article Behavioral Sciences

Effects of 5-HT5A receptor blockade on amnesia or forgetting

L. Aparicio-Nava et al.

BEHAVIOURAL BRAIN RESEARCH (2019)

Article Geriatrics & Gerontology

Aging-related impairments of hippocampal mossy fibers synapses on CA3 pyramidal cells

Cindy Villanueva-Castillo et al.

NEUROBIOLOGY OF AGING (2017)

Article Neurosciences

Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources

Inseon Song et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2013)

Article Medicine, Research & Experimental

5-HT6 receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia

Julie Meffre et al.

EMBO MOLECULAR MEDICINE (2012)

Article Behavioral Sciences

GABA, glutamate, dopamine and serotonin transporters expression on forgetting

Ruth Tellez et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2012)

Article Neurosciences

Unitary inhibitory field potentials in the CA3 region of rat hippocampus

Michael Bazelot et al.

JOURNAL OF PHYSIOLOGY-LONDON (2010)

Article Behavioral Sciences

Time-course of 5-HT6 receptor mRNA expression during memory consolidation and amnesia

A. Huerta-Rivas et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2010)

Review Behavioral Sciences

Memory formation, amnesia, improved memory and reversed amnesia: 5-HT role

G. Perez-Garcia et al.

BEHAVIOURAL BRAIN RESEARCH (2008)

Article Neurosciences

Serotonin increases GABA release in rat entorhinal cortex by inhibiting interneuron TASK-3 K+ channels

Pan-Yue Deng et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2008)

Article Behavioral Sciences

An mRNA expression analysis of stimulation and blockade of 5-HT7 receptors during memory consolidation

G Pérez-García et al.

BEHAVIOURAL BRAIN RESEARCH (2006)

Review Pharmacology & Pharmacy

5-HT6 receptors:: a novel target for cognitive enhancement

ES Mitchell et al.

PHARMACOLOGY & THERAPEUTICS (2005)

Article Chemistry, Medicinal

2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists

C Mattsson et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)

Article Behavioral Sciences

8-OH-DPAT facilitated memory consolidation and increased hippocampal and cortical CAMP production

L Manuel-Apolinar et al.

BEHAVIOURAL BRAIN RESEARCH (2004)

Article Neurosciences

5-ht(6) Receptors

Marie L. Woolley et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2004)

Article Neurosciences

Hippocampal lesions, contextual retrieval, and autoshaping in pigeons

J Richmond et al.

BRAIN RESEARCH (2002)

Article Pharmacology & Pharmacy

Anti-ischemic and cognition-enhancing properties of NNC-711, a γ-aminobutyric acid reuptake inhibitor

AW O'Connell et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2001)