4.7 Article

A novel monobactam lacking antimicrobial activity, MC-100093, reduces sex-specific ethanol preference and depressive-like behaviors in mice

Related references

Note: Only part of the references are listed.
Article Neurosciences

N-6-substituated adenosine analog J4 attenuates anxiety-like behaviors in mice

Lee Peyton et al.

Summary: This study investigates the effects of J4, an adenosine analog, on alleviating alcohol withdrawal-related affective behaviors. The results show that J4 treatment reduces anxiety-like behavior and increases time spent in open arms, suggesting its potential as a general anxiolytic.

PSYCHOPHARMACOLOGY (2022)

Article Substance Abuse

Clinical management of the alcohol withdrawal syndrome

Ed Day et al.

Summary: This clinical review discusses key elements of the clinical management of medically assisted withdrawal (MAW) for alcohol use disorder, including necessary adjustments for pregnancy and older adults, likely outcomes, factors that might prevent completion of the MAW process, and ways of overcoming barriers to ongoing treatment. The review also covers the use of benzodiazepines in MAW, highlighting potential risks despite clear evidence of their efficacy. Strategies for anti-glutamatergic approaches in MAW and other potential treatment innovations are also considered due to their role in alcohol withdrawal.

ADDICTION (2022)

Article Biochemistry & Molecular Biology

Role of suppressing GLT-1 and xCT in ceftriaxone-induced attenuation of relapse-like alcohol drinking in alcohol-preferring rats

Sujan C. Das et al.

Summary: Alcohol dependence leads to changes in glutamate homeostasis in the nucleus accumbens (NAc), but relapse-like ethanol drinking does not affect the gene and protein expression of GLT-1 and xCT in NAc. Treatment with ceftriaxone can attenuate relapse-like ethanol drinking, and the upregulation of both GLT-1 and xCT is crucial for this attenuation.

ADDICTION BIOLOGY (2022)

Article Behavioral Sciences

Sex Differences in Depression-Like Behaviors in Adult Mice Depend on Endophenotype and Strain

Claudia Pitzer et al.

Summary: Depression affects women nearly twice as frequently as men, but results from rodent models of depression have shown inconsistent sex biases. This study investigates sex differences in baseline depression-like behaviors in adult mice and finds strain-dependent differences in apathy-like behaviors. These findings highlight the complexity of sex effects on depression endophenotypes and stress the importance of considering strain in depression model research.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2022)

Review Neurosciences

Ceftriaxone as a Novel Therapeutic Agent for Hyperglutamatergic States: Bridging the Gap Between Preclinical Results and Clinical Translation

Osama A. Abulseoud et al.

Summary: This review explores the translational potential of CEF in neuropsychiatric disorders based on preclinical efficacy, highlighting its possible clinical effectiveness in selected cases of acute and transient hyperglutamatergic states such as early drug withdrawal conditions.

FRONTIERS IN NEUROSCIENCE (2022)

Article Pharmacology & Pharmacy

Effects of a Novel Beta Lactam Compound, MC-100093, on the Expression of Glutamate Transporters/Receptors and Ethanol Drinking Behavior of Alcohol-Preferring Rats

Hasan Alhaddad et al.

Summary: This study identified a novel beta-lactam, MC-100093, that has demonstrated upregulatory effects on GLT-1. MC-100093 reduced ethanol drinking behavior and normalized levels of GLT-1 and xCT expression in the NAc shell as well as normalized GLT-1 and PPAR-alpha expression in the liver. In addition, MC-100093 attenuated ethanol-induced increases in fat droplet content in the liver.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2022)

Article Substance Abuse

Effects of ceftriaxone on ethanol drinking and GLT-1 expression in ethanol dependence and relapse drinking

William C. Griffin et al.

Summary: The study found that ceftriaxone did not influence drinking behavior in either ethanol-dependent or non-dependent mice, and did not increase GLT-1 expression in the accumbens core or shell, except in ethanol-dependent mice receiving the highest dose. Ethanol-dependent mice showed reduced expression of GLT-1 and mGlu2, which may help explain increased glutamatergic transmission in this model.

ALCOHOL (2021)

Review Clinical Neurology

Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status

Ioline D. Henter et al.

Summary: The efficacy of standard antidepressants is limited for many patients with mood disorders, highlighting the urgent need for novel therapeutics. Both clinical and preclinical studies have suggested dysfunction in the glutamatergic system plays a role in the pathophysiology of mood disorders, with ketamine and similar glutamatergic modulators showing rapid reduction in depressive symptoms.

CNS DRUGS (2021)

Article Pharmacology & Pharmacy

MC-100093, a Novel β-Lactam Glutamate Transporter-1 Enhancer Devoid of Antimicrobial Properties, Attenuates Cocaine Relapse in Rats

Lori A. Knackstedt et al.

Summary: The newly developed drug MC-100093 has shown the ability to upregulate GLT-1 expression and reduce cocaine seeking without significant side effects.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2021)

Article Biochemistry & Molecular Biology

Drug Delivery Challenges in Brain Disorders across the Blood-Brain Barrier: Novel Methods and Future Considerations for Improved Therapy

Aneesha Achar et al.

Summary: Various strategies have been researched to overcome the blood-brain barrier (BBB) for use in treating conditions like epilepsy, stroke, brain cancer, and traumatic brain injury. Interventions using technological and mechanical tools have been designed to enhance drug bioavailability in the treatment of severe brain disorders.

BIOMEDICINES (2021)

Review Neurosciences

Blood-brain barrier regulation in psychiatric disorders

John Kealy et al.

NEUROSCIENCE LETTERS (2020)

Article Substance Abuse

Increased Responding for Alcohol and Resistance to Aversion in Female Mice

Elizabeth A. Sneddon et al.

ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH (2020)

Article Behavioral Sciences

Astrocytic Glutamate Transporter 1 (GLT1) Deficiency Reduces Anxiety- and Depression-Like Behaviors in Mice

Jia Yun-Fang et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2020)

Review Substance Abuse

SLC Neurotransmitter Transporters as Therapeutic Targets for Alcohol Use Disorder: A Narrative Review

Eliza R. McColl et al.

ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH (2020)

Review Neurosciences

Sex differences in antidepressant efficacy

Tara A. LeGates et al.

NEUROPSYCHOPHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Serial exposure to ethanol drinking and methamphetamine enhances glutamate excitotoxicity

Amanda L. Blaker et al.

JOURNAL OF NEUROCHEMISTRY (2019)

Article Pharmacology & Pharmacy

Novel Adenosine Analog, N6-(4-Hydroxybenzyl)-Adenosine, Dampens Alcohol Drinking and Seeking Behaviors

Sa-Ik Hong et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2019)

Review Clinical Neurology

Cortical thickness in major depressive disorder: A systematic review and meta-analysis

Jee Su Suh et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2019)

Article Neuroimaging

Anxiety, depression, impulsivity, and brain structure in children and adolescents

Emily C. Merz et al.

NEUROIMAGE-CLINICAL (2018)

Review Clinical Neurology

Alcohol withdrawal syndrome: mechanisms, manifestations, and management

S. Jesse et al.

ACTA NEUROLOGICA SCANDINAVICA (2017)

Article Multidisciplinary Sciences

Midbrain circuit regulation of individual alcohol drinking behaviors in mice

Barbara Juarez et al.

NATURE COMMUNICATIONS (2017)

Review Pharmacology & Pharmacy

Sex Differences in Animal Models: Focus on Addiction

Jill B. Becker et al.

PHARMACOLOGICAL REVIEWS (2016)

Review Neurosciences

An excitatory synapse hypothesis of depression

Scott M. Thompson et al.

TRENDS IN NEUROSCIENCES (2015)

Review Neurosciences

Targeting glutamate uptake to treat alcohol use disorders

P. S. S. Rao et al.

FRONTIERS IN NEUROSCIENCE (2015)

Article Neurosciences

Attenuation of Ethanol Withdrawal by Ceftriaxone-Induced Upregulation of Glutamate Transporter EAAT2

Osama A. Abulseoud et al.

NEUROPSYCHOPHARMACOLOGY (2014)

Article Biochemistry & Molecular Biology

Ceftriaxone Treatment Affects the Levels of GLT1 and ENT1 As Well As Ethanol Intake in Alcohol-Preferring Rats

Youssef Sari et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2013)

Review Substance Abuse

Adenosine and Glutamate Signaling in Neuron-Glial Interactions: Implications in Alcoholism and Sleep Disorders

Hyung W. Nam et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2012)

Article Substance Abuse

Preclinical studies of alcohol binge drinking

John C. Crabbe et al.

ADDICTION REVIEWS (2011)

Article Biochemistry & Molecular Biology

Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory

E. Y. Yuen et al.

MOLECULAR PSYCHIATRY (2011)

Review Biochemistry & Molecular Biology

Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes

Robert F. Leeman et al.

ADDICTION BIOLOGY (2010)

Article Clinical Neurology

Glial and glutamatergic markers in depression, alcoholism, and their comorbidity

Jose Javier Miguel-Hidalgo et al.

JOURNAL OF AFFECTIVE DISORDERS (2010)

Review Neurosciences

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

Giles E. Hardingham et al.

NATURE REVIEWS NEUROSCIENCE (2010)

Article Health Policy & Services

What Did STAR*D Teach Us? Results From a Large-Scale, Practical, Clinical Trial for Patients With Depression

Bradley N. Gaynes et al.

PSYCHIATRIC SERVICES (2009)

Article Neurosciences

Abnormal Glutamatergic Neurotransmission and Neuronal-Glial Interactions in Acute Mania

Dost Oenguer et al.

BIOLOGICAL PSYCHIATRY (2008)

Review Biotechnology & Applied Microbiology

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

Gerard Sanacora et al.

NATURE REVIEWS DRUG DISCOVERY (2008)

Article Biology

Neurobiological mechanisms for opponent motivational processes in addiction

George F. Koob et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2008)

Article Neurosciences

Antidepressant-like effects of ceftriaxone in male C57BL/6J mice

Yann S. Mineur et al.

BIOLOGICAL PSYCHIATRY (2007)

Article Multidisciplinary Sciences

Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression

PV Choudary et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Psychiatry

Lower hippocampal volume in patients suffering from depression: A meta-analysis

S Campbell et al.

AMERICAN JOURNAL OF PSYCHIATRY (2004)

Article Neurosciences

Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes

M Hamidi et al.

BIOLOGICAL PSYCHIATRY (2004)

Article Psychology, Developmental

Reduced anterior cingulate cortex glutamatergic concentrations in childhood major depression

Y Mirza et al.

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY (2004)

Review Neurosciences

Glial cell abnormalities in major psychiatric disorders: The evidence and implications

DR Cotter et al.

BRAIN RESEARCH BULLETIN (2001)