Journal
MOLECULAR ONCOLOGY
Volume 11, Issue 1, Pages 28-39Publisher
WILEY
DOI: 10.1002/1878-0261.12017
Keywords
cancer; circulating tumor cells; epithelial-mesenchymal transition; invasion; metastasis; progression
Categories
Funding
- National Cancer Institute [1RO1CA168689, 1R01CA174869, 1R01CA206880]
- DOD Breast Cancer Program [W81XWH-13-1-0132]
- NCI Growth Regulation and Oncogenesis Training Grant [T32CA009523]
- NATIONAL CANCER INSTITUTE [R01CA174869, T32CA009523, R01CA168689, R01CA206880] Funding Source: NIH RePORTER
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The epithelial-mesenchymal transition (EMT) is a developmental program that enables stationary epithelial cells to gain the ability to migrate and invade as single cells. Tumor cells reactivate EMT to acquire molecular alterations that enable the partial loss of epithelial features and partial gain of a mesenchymal phenotype. Our understanding of the contribution of EMT to tumor invasion, migration, and metastatic outgrowth has evolved over the past decade. In this review, we provide a summary of both historic and recent studies on the role of EMT in the metastatic cascade from various experimental systems, including cancer cell lines, genetic mouse tumor models, and clinical human breast cancer tissues.
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