Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 60, Issue 4, Pages 810-822Publisher
WILEY
DOI: 10.1002/mnfr.201500735
Keywords
Calcium therapy; Early weaning; Obesity; Vitamin D
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Funding
- 'National Council for Scientific and Technological Development' (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq)
- 'Carlos Chagas Filho Research Foundation of the State of Rio de Janeiro' (Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro-FAPERJ)
- FAPERJ
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ScopeEarly weaning (EW) is associated with an impairment of offspring development and leads to overweight and higher 25-hydroxyvitamin D (25(OH)D) levels in adulthood, which can be corrected by calcium supplementation, potentially via vitamin D regulation of adipogenesis. Methods and ResultsWe examined vitamin D status in adipose tissue in EW obese rats, treated with calcium. Dams were separated into: EW- dams were wrapped with a bandage to interrupt lactation (last 3 days), and C- pups with free access to milk. At PN120, EW pups were divided in: EW- standard diet, and EWCa- calcium supplementation (10 g of calcium carbonate/kg of chow). On PN21, EW group has hypocalcemia. On PN180, EW group showed lower intestinal calbidin, higher adiposity, and 25(OH)D. In adipose tissue, Cyp27b1/1alpha-Hydroxylase, C/EBPB, PPAR-, IL6, TNF-A, and MCP1 were increased, while VDR and IL10 were decreased. Calcium increased calbidin, VDR and prevented adipose tissue dysfunction. EW group has a long-term effect of vitamin D on adipocyte, contributing to pro-inflammatory status and obesity. ConclusionWe propose that in obese rat adipocytes, 1,25(OH)(2)D down-regulates VDR, resulting in vitamin D resistance, characterized by higher Cyp27b1/1-Hydroxylase and adipogenesis. Calcium therapy appears to be an outstanding strategy for weight loss and improving endocrine metabolic disorders that are obesity associated.
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