4.7 Review

The extracellular matrix as modifier of neuroinflammation and recovery in ischemic stroke and intracerebral hemorrhage

Related references

Note: Only part of the references are listed.
Article Neurosciences

Brain edema formation and therapy after intracerebral hemorrhage

Yingfeng Wan et al.

Summary: Intracerebral hemorrhage (ICH) is responsible for 10% of strokes in the USA, resulting in significant disability and mortality. It causes primary brain injury due to mechanical disruption and secondary injury through the release of clot-derived factors. ICH leads to brain edema and increased intracranial pressure, affecting patient prognosis. Currently, effective treatment methods for reducing perihematomal cerebral edema and intracranial pressure are limited. This review explores the mechanisms of edema formation, the influence of sex and age, and the progress in pharmacotherapy for ICH.

NEUROBIOLOGY OF DISEASE (2023)

Article Neurosciences

The transcriptomic landscape of neurons carrying PSEN1 mutations reveals changes in extracellular matrix components and non-coding gene expression

Giulia I. Corsi et al.

Summary: Alzheimer's disease (AD) is a progressive and irreversible brain disorder caused by complex factors. This study investigates the gene expression changes in neurons with fAD mutations in the PSEN1 gene using hiPSCs. The analysis reveals significant alterations in genes related to extracellular matrix, calcium homeostasis, mitochondrial oxidative stress, and circular RNA. These findings contribute to a better understanding of the cellular mechanisms in AD neurons.

NEUROBIOLOGY OF DISEASE (2023)

Article Clinical Neurology

Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages

Ruiyi Zhang et al.

Summary: This study found that activating Liver X receptor (LXR) can reduce brain injury, promote beneficial properties of microglia/macrophages (M/M), and facilitate tissue repair.

STROKE AND VASCULAR NEUROLOGY (2023)

Article Neurosciences

SerpinA3N attenuates ischemic stroke injury by reducing apoptosis and neuroinflammation

Yu Zhang et al.

Summary: SerpinA3N is expressed in astrocytes and penumbra neurons after stroke in mice. It reduces brain damage possibly via interacting with clusterin and inhibiting neuronal apoptosis and neuroinflammation.

CNS NEUROSCIENCE & THERAPEUTICS (2022)

Article Endocrinology & Metabolism

Tenascin-C induction exacerbates post-stroke brain damage

Bharath Chelluboina et al.

Summary: The study found that TNC knockdown following a stroke can significantly reduce TNC protein expression, improve motor function deficits, decrease infarct volume, BBB damage, and inflammation.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2022)

Review Neurosciences

Primary cilia and ciliary signaling pathways in aging and age-related brain disorders

Rong Ma et al.

Summary: This review discusses the role of primary cilia in brain disorders, highlighting aging as a major risk factor and examining various cellular and molecular events involved in the progression of these diseases.

NEUROBIOLOGY OF DISEASE (2022)

Article Endocrinology & Metabolism

Aging related impairment of brain microvascular bioenergetics involves oxidative phosphorylation and glycolytic pathways

Siva S. V. P. Sakamuri et al.

Summary: Mitochondrial and glycolytic energy pathways play a crucial role in regulating vascular function, and aging can affect the energetics of brain microvessels, making them more vulnerable to injury.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2022)

Article Biochemistry & Molecular Biology

Tenascin-C restricts reactive astrogliosis in the ischemic brain

Egor Dzyubenko et al.

Summary: Cellular responses in glia play a key role in regulating brain remodeling post-stroke. Excessive glial reactivity impedes neuroplasticity and hampers neurological recovery. We found that tenascin-C (TnC) plays a central role in restraining astrogliosis and regulating astrocyte-microglial interactions.

MATRIX BIOLOGY (2022)

Article Biochemistry & Molecular Biology

EMMPRIN Promotes the Expression of MMP-9 and Exacerbates Neurological Dysfunction in a Mouse Model of Intracerebral Hemorrhage

Yang Liu et al.

Summary: EMMPRIN plays a vital role as an inflammatory mediator in intracerebral hemorrhage (ICH) and contributes to the upregulation of MMP-9. Inhibiting EMMPRIN expression can reduce brain injury and promote neurological recovery.

NEUROCHEMICAL RESEARCH (2022)

Article Medicine, Research & Experimental

Intracerebral hemorrhage alters α2δ1 and thrombospondin expression in rats

Bingqian Wang et al.

Summary: This study found that the expression levels of alpha 2 delta 1 and TSP1/2 in brain tissues can be altered by ICH, which in turn affects synapse formation and functional recovery.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

Article Multidisciplinary Sciences

Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination

Samira Ghorbani et al.

Summary: Ghorbani and colleagues have found that versican-V1 acts as an inhibitor of oligodendrocyte regeneration by directly inhibiting oligodendrocytes and promoting the production of Th17 cells. In experimental models of multiple sclerosis, versican-V1 is selectively upregulated among other chondroitin sulfate proteoglycans (CSPGs). The study suggests that reducing CSPG levels could be a potential therapeutic approach for promoting repair and modulating the immune response in multiple sclerosis.

NATURE COMMUNICATIONS (2022)

Review Cell Biology

Perlecan, A Multi-Functional, Cell-Instructive, Matrix-Stabilizing Proteoglycan With Roles in Tissue Development Has Relevance to Connective Tissue Repair and Regeneration

Anthony J. Hayes et al.

Summary: This review highlights the multifunctional properties of perlecan and its potential roles in repair biology. Perlecan is a ubiquitous molecule found in various tissues and plays important roles in angiogenesis, tissue development, and neuro-muscular control. It interacts with various growth factors and promotes tissue repair and regeneration. A greater understanding of perlecan's diverse biological roles and functional repertoires is crucial for the successful utilization of this proteoglycan in repair biology.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Article Endocrinology & Metabolism

Female-specific neuroprotection after ischemic stroke by vitronectin-focal adhesion kinase inhibition

Cuihong Jia et al.

Summary: Blood vitronectin (VTN) leaking into the brain after stroke exacerbates tissue loss by increasing IL-6 expression in female mice. Inhibiting focal adhesion kinase (FAK) reduces brain injury size, inflammation, and motor dysfunction in female, but not male, mice. Selective gene deletion of FAK in astrocytes reduces IL-6 expression and mitigates infarct size and inflammation. VTN signaling can be targeted to mitigate harmful inflammation in female stroke patients.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2022)

Article Biochemistry & Molecular Biology

Neuroprotective Effects of Chlorogenic Acid in a Mouse Model of Intracerebral Hemorrhage Associated with Reduced Extracellular Matrix Metalloproteinase Inducer

Yang Liu et al.

Summary: This study found that chlorogenic acid (CGA) can provide neuroprotection in intracerebral hemorrhage (ICH) by inhibiting the expression of EMMPRIN and MMP-2/9, alleviating neuroinflammation, blood-brain barrier disruption, cell death, and brain injury.

BIOMOLECULES (2022)

Review Neurosciences

Sexual dimorphism in immune cell responses following stroke

Jialing Liu et al.

Summary: Recent studies on stroke have found significant differences between sexes in terms of risk and outcome. Although earlier research has focused on differences in sex hormones, the reasons for these differences are more complex. This review examines differences in sex-related immune responses, highlighting disparities in immune cell composition and function. While females are more susceptible to immune-related diseases, experimental findings suggest they have better outcomes from stroke with reduced pro-inflammatory responses.

NEUROBIOLOGY OF DISEASE (2022)

Review Pharmacology & Pharmacy

Fibronectin in development and wound healing

Jennifer Patten et al.

Summary: Fibronectin structure and composition play a crucial role in regulating contextual cell signaling. Recent advances in understanding fibronectin and its functions have led to evaluations of potential therapeutic strategies and discussions on modulating fibronectin function for development and wound healing.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Immunology

Tenascin-C preserves microglia surveillance and restricts leukocyte and, more specifically, T cell infiltration of the ischemic brain

Daniel Manrique-Castano et al.

Summary: The study shows that TnC deficiency affects the morphology and quantity of microglial cells, reducing their surveillance capabilities and increasing the accumulation of infiltrating leukocytes (especially T cells) in the ischemic brain.

BRAIN BEHAVIOR AND IMMUNITY (2021)

Article Clinical Neurology

The role of fibrinogen in acute ischaemic stroke

Marieta Peycheva et al.

Summary: This study aimed to explore the associations between fibrinogen and acute ischaemic stroke, neurological impairment, cerebral ischaemia, and clinical evaluation of stroke patients. The results showed that fibrinogen is a reliable biomarker that could characterise acute ischaemic stroke, with high levels of fibrinogen being potentially indicative of ischaemic stroke. Fibrinogen levels were associated with different stroke subtypes and the presence of ischaemic lesions on cerebral CT, but no significant connection was found between fibrinogen levels and neurological deficits.

NEUROLOGIA I NEUROCHIRURGIA POLSKA (2021)

Article Clinical Neurology

Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

Valery L. Feigin et al.

Summary: Regularly updated data on stroke including incidence, prevalence, mortality, disability, risk factors, and trends are crucial for evidence-based care planning. The Global Burden of Diseases Study provides comprehensive measurement of these metrics. From 1990 to 2019, while age-standardized rates improved, the number of strokes and deaths increased. Low-income countries had the highest stroke-related mortality and DALY rates, with high body-mass index being the fastest-growing risk factor.

LANCET NEUROLOGY (2021)

Article Endocrinology & Metabolism

Transcriptome analysis reveals sexual disparities in gene expression in rat brain microvessels

Partha K. Chandra et al.

Summary: This study reveals significant sex disparities in gene expression and canonical pathways of brain microvessels, with male microvessels showing differential expression in genes related to glycosylphosphatidylinositol and steroid synthesis, while female microvessels mainly involve respiratory chain and ribosome pathways.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2021)

Review Clinical Neurology

The extracellular matrix as modifier of neuroinflammation and remyelination in multiple sclerosis

Samira Ghorbani et al.

Summary: Failure of remyelination in multiple sclerosis lesions is influenced by changes in extracellular matrix components, which not only impair oligodendrocyte recruitment but also enhance inflammatory responses. The deposition of matrix members is mainly due to cells such as reactive astrocytes and microglia/macrophages, leading to both pro-inflammatory and anti-inflammatory effects within the lesions.

BRAIN (2021)

Article Immunology

Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke

Ligen Shi et al.

Summary: The study found that after experimental stroke, Treg cells infiltrate the brain in mice and promote white matter repair and functional recovery. Treg cells enhance microglial reparative activity, promoting oligodendrogenesis and white matter repair. Increasing Treg cell numbers can improve white matter integrity and rescue neurological functions in the long term.

IMMUNITY (2021)

Article Biochemistry & Molecular Biology

Bioactive Flavonoids Icaritin and Icariin Protect against Cerebral Ischemia-Reperfusion-Associated Apoptosis and Extracellular Matrix Accumulation in an Ischemic Stroke Mouse Model

Cheng-Tien Wu et al.

Summary: This study found that both ICA and ICT have neuroprotective effects in acute cerebral ischemic stroke mice, with ICT showing slightly better results than ICA. Pretreatment with both ICA and ICT improves neuronal cell apoptosis, responses to oxidative/nitrosative stress, and counteracts ECM accumulation in the brains of acute cerebral ischemic stroke mice.

BIOMEDICINES (2021)

Article Cardiac & Cardiovascular Systems

Plasma osteopontin levels and adverse clinical outcomes after ischemic stroke

Zhengbao Zhu et al.

Summary: Elevated plasma osteopontin levels at baseline were found to be associated with increased risks of adverse clinical outcomes at 1 year after ischemic stroke in this study.

ATHEROSCLEROSIS (2021)

Article Endocrinology & Metabolism

Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: A longitudinal study

Rui Wang et al.

Summary: This longitudinal study of cognitively healthy adults found that age-related decline in cerebral perfusion was associated with APOE-genotype and sex, with female-e4 carriers showing a faster decline. Additionally, worse cardiometabolic profiles were linked to lower cerebral perfusion across all visits. Adjusting for cardiometabolic measurements weakened the synergistic effect of sex and APOE-e4 on cerebral perfusion trajectories.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2021)

Article Neurosciences

Osteopontin regulates proliferation, migration, and survival of astrocytes depending on their activation phenotype

Sabine Ulrike Vay et al.

Summary: The glycoprotein osteopontin is considered a crucial regulator in CNS disorders like ischemic stroke, influencing cell growth, adhesion, and survival. Research suggests that osteopontin can impact the activation state and survival of astrocytes, making it a promising target for experimental therapies aimed at modulating neuroregeneration and repair.

JOURNAL OF NEUROSCIENCE RESEARCH (2021)

Article Multidisciplinary Sciences

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions

David O. Dias et al.

Summary: The study reveals that fibrotic scarring is common in mice and humans following central nervous system lesions, deriving from a distinct population of GLAST-expressing perivascular cells.

NATURE COMMUNICATIONS (2021)

Article Geriatrics & Gerontology

A Shift in Tissue Stiffness During Hippocampal Maturation Correlates to the Pattern of Neurogenesis and Composition of the Extracellular Matrix

Youngjae Ryu et al.

Summary: The study examined how aging affects the mechanical properties of brain tissue, particularly focusing on the impact of neural stem cells (NSCs) in differentiating regions of the hippocampus. It found that stiffness in the brain is influenced by the composition of extracellular matrix (ECM), specifically chondroitin sulfate proteoglycans (CSPGs), which can affect postnatal neurogenesis by altering the mechanical environment of the NSC niche.

FRONTIERS IN AGING NEUROSCIENCE (2021)

Review Endocrinology & Metabolism

Principles and requirements for stroke recovery science

Clemens J. Sommer et al.

Summary: Disappointing results in translating neuroprotective strategies from bench-to-bedside have led stroke research to shift towards enhancing the brain’s endogenous recovery potential. Focus on recovery is due to the wider time window for therapeutic interventions after stroke. Understanding spontaneously occurring post-ischemic regeneration processes is crucial for modifying responses to enhance post-stroke recovery.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2021)

Article Cell Biology

Neuronal protein-tyrosine phosphatase 1B hinders sensory-motor functional recovery and causes affective disorders in two different focal ischemic stroke models

Shelly A. Cruz et al.

Summary: The study identified neuronal PTP1B as a key factor hindering sensory and motor functional recovery and contributing to the development of anxiety-like and depression-like behaviors after stroke, suggesting PTP1B as a potential therapeutic target for improving stroke recovery.

NEURAL REGENERATION RESEARCH (2021)

Review Biochemistry & Molecular Biology

New Insights into ADAMTS Metalloproteases in the Central Nervous System

Yamina Mohamedi et al.

BIOMOLECULES (2020)

Review Clinical Neurology

Neuroinflammation after Intracerebral Hemorrhage and Potential Therapeutic Targets

Christine Tschoe et al.

JOURNAL OF STROKE (2020)

Review Clinical Neurology

Basement Membrane Changes in Ischemic Stroke

Minkyung Kang et al.

STROKE (2020)

Article Immunology

The neuroregenerative effects of topical decorin on the injured mouse cornea

Mengliang Wu et al.

JOURNAL OF NEUROINFLAMMATION (2020)

Review Biochemistry & Molecular Biology

Extracellular matrix-derived peptides in tissue remodeling and fibrosis

Lisandra E. de Castro Bras et al.

MATRIX BIOLOGY (2020)

Review Cell Biology

The Influence of Neuron-Extrinsic Factors and Aging on Injury Progression and Axonal Repair in the Central Nervous System

Theresa C. Sutherland et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Diverse Roles for Hyaluronan and Hyaluronan Receptors in the Developing and Adult Nervous System

Alec Peters et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Cell Biology

Versican: A Dynamic Regulator of the Extracellular Matrix

Shamima Islam et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2020)

Article Medicine, General & Internal

Osteopontin Predicts Three-Month Outcome in Stroke Patients Treated by Reperfusion Therapies

Elena Meseguer et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Review Biochemistry & Molecular Biology

Hyaluronan: Metabolism and Function

Takashi Kobayashi et al.

BIOMOLECULES (2020)

Article Medicine, General & Internal

A snapshot of Ischemic stroke risk factors, sub-types, and its epidemiology: Cohort study

Khaled Z. Alawneh et al.

ANNALS OF MEDICINE AND SURGERY (2020)

Review Immunology

Fibrotic Scar in Neurodegenerative Diseases

Nadia D'Ambrosi et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Endocrinology & Metabolism

Basement membrane and stroke

Yao Yao

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2019)

Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2019 Update A Report From the American Heart Association

Emelia J. Benjamin et al.

CIRCULATION (2019)

Article Chemistry, Multidisciplinary

Local delivery of stabilized chondroitinase ABC degrades chondroitin sulfate proteoglycans in stroke-injured rat brains

Marian H. Hettiaratchi et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Article Cell Biology

Distinct proteomic profiles in monozygotic twins discordant for ischaemic stroke

Nirmal Vadgama et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2019)

Article Neurosciences

Mural cell-derived laminin-5 plays a detrimental role in ischemic stroke

Abhijit Nirwane et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)

Review Clinical Neurology

Intracerebral hemorrhage: an update on diagnosis and treatment

Isabel C. Hostettler et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2019)

Review Neurosciences

The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

James W. Fawcett et al.

NATURE REVIEWS NEUROSCIENCE (2019)

Article Multidisciplinary Sciences

Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke

Ruslan Rust et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Biochemistry & Molecular Biology

Basement membrane collagens and disease mechanisms

Anna Gatseva et al.

EXTRACELLULAR MATRIX (2019)

Article Multidisciplinary Sciences

Niche stiffness underlies the ageing of central nervous system progenitor cells

Michael Segel et al.

NATURE (2019)

Review Neurosciences

Potential roles of matricellular proteins in stroke

Fumihiro Kawakita et al.

EXPERIMENTAL NEUROLOGY (2019)

Review Cell Biology

Heparan sulfate as a regulator of inflammation and immunity

Laura E. Collins et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

Article Neurosciences

Osteopontin Attenuates Secondary Neurodegeneration in the Thalamus after Experimental Stroke

Anne Ladwig et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2019)

Review Medical Laboratory Technology

The multiple functions and mechanisms of osteopontin

Mehmet Arif Icer et al.

CLINICAL BIOCHEMISTRY (2018)

Review Cell Biology

The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies

Brooke L. Farrugia et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Pro-inflammatory roles of chondroitin sulfate proteoglycans in disorders of the central nervous system

Erin L. Stephenson et al.

MATRIX BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Fibrotic scarring following lesions to the central nervous system

David Oliveira Dias et al.

MATRIX BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Topological remodeling of cortical perineuronal nets in focal cerebral ischemia and mild hypoperfusion

Egor Dzyubenko et al.

MATRIX BIOLOGY (2018)

Review Clinical Neurology

Role of immune responses for extracellular matrix remodeling in the ischemic brain

Egor Dzyubenko et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2018)

Article Biochemistry & Molecular Biology

Versican Deficiency Significantly Reduces Lung Inflammatory Response Induced by Polyinosine-Polycytidylic Acid Stimulation

Inkyung Kang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Review Biochemistry & Molecular Biology

The nature and biology of basement membranes

Ambra Pozzi et al.

MATRIX BIOLOGY (2017)

Article Cell Biology

Lack of collagen XV is protective after ischemic stroke in mice

Hiramani Dhungana et al.

CELL DEATH & DISEASE (2017)

Review Biotechnology & Applied Microbiology

The Effect of Osteopontin on Microglia

Huan Yu et al.

BIOMED RESEARCH INTERNATIONAL (2017)

Review Pharmacology & Pharmacy

Osteopontin as a Potential Therapeutic Target for Ischemic Stroke

Qiquan Zhu et al.

CURRENT DRUG DELIVERY (2017)

Article Behavioral Sciences

Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep

Wolfgang Haertig et al.

FRONTIERS IN INTEGRATIVE NEUROSCIENCE (2017)

Article Biochemistry & Molecular Biology

Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1β synthesis

Louise Tzung-Harn Hsieh et al.

MATRIX BIOLOGY (2016)

Article Multidisciplinary Sciences

Astrocyte scar formation aids central nervous system axon regeneration

Mark A. Anderson et al.

NATURE (2016)

Article Multidisciplinary Sciences

Secreted Thrombospondin-1 Regulates Macrophage Interleukin-1β Production and Activation through CD47

Erica V. Stein et al.

SCIENTIFIC REPORTS (2016)

Article Medical Laboratory Technology

Changes in plasma thrombospondin-1 concentrations following acute intracerebral hemorrhage

Xiao-Qiao Dong et al.

CLINICA CHIMICA ACTA (2015)

Article Multidisciplinary Sciences

Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury

Bradley T. Lang et al.

NATURE (2015)

Review Cell Biology

Tenascin-C: Form versus function

Sean P. Giblin et al.

CELL ADHESION & MIGRATION (2015)

Review Neurosciences

Sex differences in stroke: The contribution of coagulation

Meaghan Roy-O'Reilly et al.

EXPERIMENTAL NEUROLOGY (2014)

Article Medicine, General & Internal

Glial Scar Formation Occurs in the Human Brain after Ischemic Stroke

Lijie Huang et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2014)

Article Biochemistry & Molecular Biology

De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88/TRIF pathways

Jinyang Zeng-Brouwers et al.

MATRIX BIOLOGY (2014)

Review Biotechnology & Applied Microbiology

Chondroitin Sulfate Proteoglycans in the Nervous System: Inhibitors to Repair

Justin R. Siebert et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Article Rheumatology

Aggrecanases in the human synovial fluid at different stages of osteoarthritis

Enshui Zhang et al.

CLINICAL RHEUMATOLOGY (2013)

Review Biochemistry & Molecular Biology

Biological interplay between proteoglycans and their innate immune receptors in inflammation

Helena Frey et al.

FEBS JOURNAL (2013)

Review Neurosciences

OPINION Pathophysiology of the brain extracellular matrix: a new target for remyelination

Lorraine W. Lau et al.

NATURE REVIEWS NEUROSCIENCE (2013)

Article Cell Biology

The laminin family

Monique Aumailley

CELL ADHESION & MIGRATION (2013)

Review Immunology

Heparan sulfate: a ubiquitous glycosaminoglycan with multiple roles in immunity

David Anak Simon Davis et al.

FRONTIERS IN IMMUNOLOGY (2013)

Article Clinical Neurology

Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination

Lorraine W. Lau et al.

ANNALS OF NEUROLOGY (2012)

Article Neurosciences

NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans

Travis L. Dickendesher et al.

NATURE NEUROSCIENCE (2012)

Article Biochemistry & Molecular Biology

Dynamic Reduction of Plasma Decorin Following Ischemic Stroke: A Pilot Study

Yuan-Zhi Xu et al.

NEUROCHEMICAL RESEARCH (2012)

Article Multidisciplinary Sciences

Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination

S. Y. Christin Chong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats

Justin J. Hill et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

Hyaluronan Fragments Promote Inflammation by Down-Regulating the Anti-inflammatory A2a Receptor

Samuel L. Collins et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2011)

Article Cardiac & Cardiovascular Systems

A large screening of angiogenesis biomarkers and their association with neurological outcome after ischemic stroke

Miriam Navarro-Sobrino et al.

ATHEROSCLEROSIS (2011)

Article Developmental Biology

Extracellular Matrix and Perineuronal Nets in CNS Repair

Jessica C. F. Kwok et al.

DEVELOPMENTAL NEUROBIOLOGY (2011)

Article Biochemistry & Molecular Biology

Signaling by the Matrix Proteoglycan Decorin Controls Inflammation and Cancer Through PDCD4 and MicroRNA-21

Rosetta Merline et al.

SCIENCE SIGNALING (2011)

Article Biochemistry & Molecular Biology

The First Type III Repeat in Fibronectin Activates an Inflammatory Pathway in Dermal Fibroblasts

Ran You et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Clinical Neurology

Alteration of thrombospondin-1 and -2 in rat brains following experimental intracerebral hemorrhage

Hua-Jun Zhou et al.

JOURNAL OF NEUROSURGERY (2010)

Article Clinical Neurology

Hydrogel Matrix to Support Stem Cell Survival After Brain Transplantation in Stroke

Jin Zhong et al.

NEUROREHABILITATION AND NEURAL REPAIR (2010)

Review Immunology

The impact of the extracellular matrix on inflammation

Lydia Sorokin

NATURE REVIEWS IMMUNOLOGY (2010)

Article Biochemistry & Molecular Biology

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

Andrea Babelova et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Multidisciplinary Sciences

Perineuronal Nets Protect Fear Memories from Erasure

Nadine Gogolla et al.

SCIENCE (2009)

Review Biochemistry & Molecular Biology

Osteopontin: Role in immune regulation and stress responses

Kathryn X. Wang et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2008)

Article Endocrinology & Metabolism

Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke

Jason Liauw et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2008)

Article Clinical Neurology

Nogo-A expression after focal ischemic stroke in the adult rat

Joseph L. Cheatwood et al.

STROKE (2008)

Article Endocrinology & Metabolism

Protective role of reactive astrocytes in brain ischemia

Lizhen Li et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2008)

Article Biochemistry & Molecular Biology

Brain matrix: structure, turnover and necessity

U. Rauch

BIOCHEMICAL SOCIETY TRANSACTIONS (2007)

Article Immunology

Interactions between CD47 and thrombospondin reduce inflammation

Laurence Lamy et al.

JOURNAL OF IMMUNOLOGY (2007)

Review Cell Biology

Basement membrane proteoglycans: From cellar to ceiling

RV Iozzo

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-methylumbelliferone

I Kakizaki et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Neurosciences

Perineuronal nets potentially protect against oxidative stress

M Morawski et al.

EXPERIMENTAL NEUROLOGY (2004)

Review Neurosciences

Extracellular matrix molecules and synaptic plasticity

A Dityatev et al.

NATURE REVIEWS NEUROSCIENCE (2003)

Article Biochemistry & Molecular Biology

Opposite effects of thrombospondin-1 via CD36 and CD47 on homotypic aggregation of monocytic cells

Y Yamauchi et al.

MATRIX BIOLOGY (2002)

Article Endocrinology & Metabolism

Microvascular basal lamina injury after experimental focal cerebral ischemia and reperfusion in the rat

GF Hamann et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2002)

Article Biochemistry & Molecular Biology

Thrombospondin-1 differentially regulates release of IL-6 and IL-10 by human monocytic cell line U937

Y Yamauchi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)

Review Neurosciences

Metalloproteinases in biology and pathology of the nervous system

VW Yong et al.

NATURE REVIEWS NEUROSCIENCE (2001)

Article Biochemistry & Molecular Biology

Binding of a large chondroitin sulfate/dermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44

H Kawashima et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Biochemistry & Molecular Biology

The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage

M Tortorella et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)