Journal
MOLECULAR NEUROBIOLOGY
Volume 54, Issue 5, Pages 3131-3136Publisher
HUMANA PRESS INC
DOI: 10.1007/s12035-016-9886-2
Keywords
Alzheimer's disease; Genome-wide association study; PICALM; rs3851179; Chinese population
Categories
Funding
- National Nature Science Foundation of China [81300945, 61571152]
- National High-Tech Research and Development Program (863) of China [2012AA02A601, 2012AA02A602, 2012AA020404, 2012AA020409, 2012AA02A604, 2014AA021505, 2015AA020101, 2015AA020108]
- National Science and Technology Major Project [2013ZX03005012]
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The association between PICALM rs3851179 variant and Alzheimer's disease (AD) has been well established by previous genome-wide association studies (GWAS) and candidate gene studies in European population. Recent studies investigated the association between PICALM rs3851179 and AD susceptibility in Chinese population. However, these studies reported consistent and inconsistent results. Here, we selected 9435 samples including 3704 AD cases and 5731 controls from previous studies and evaluated this association using a meta-analysis method for additive model. We did not observe significant genetic heterogeneity in Chinese population. Our results indicate significant association between PICALM rs3851179 and AD in Chinese population. The sensitivity analysis indicates that the association between rs3851179 and AD did not vary substantially. The regression analysis suggests no significant publication bias. In summary, this updated meta-analysis highlights the involvement of PICALM rs3851179 variant in Alzheimer's disease susceptibility in Chinese population.
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