Journal
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Volume -, Issue -, Pages -Publisher
SPRINGER
DOI: 10.1007/s00210-023-02687-z
Keywords
Schisandrin; Pharmacological effects; Bioavailability; Pharmacokinetics; Mechanism of action
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Schisandrin, the primary active compound in Schisandra chinensis, exhibits various pharmacological effects in liver diseases, although its clinical efficacy is limited by hepatic and intestinal first-pass metabolism.
Schisandrin stands as one of the primary active compounds within the widely used traditional medicinal plant Schisandra chinensis (Turcz.) Baill. This compound exhibits sedative, hypnotic, anti-aging, antioxidant, and immunomodulatory properties, showcasing its effectiveness across various liver diseases while maintaining a favorable safety profile. However, the bioavailability of schisandrin is largely affected by hepatic and intestinal first-pass metabolism, which limits the clinical efficacy of schisandrin. In this paper, we review the various pharmacological effects and related mechanisms of schisandrin, in order to provide reference for subsequent drug research and promote its medicinal value.
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