4.7 Article

Spatial transcriptomics reveals the distinct organization of mouse prefrontal cortex and neuronal subtypes regulating chronic pain

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Molecular and spatial signatures of mouse brain aging at single-cell resolution

William E. Allen et al.

Summary: Using spatially resolved single-cell transcriptomics, we created a high-resolution cell atlas of brain aging and identified significant changes in gene expression and spatial organization of non-neuronal cells. Glial and immune cell activation during aging, particularly in the subcortical white matter, was observed. These findings provide critical insights into age-related decline and inflammation in the brain.
Article Anesthesiology

Prevalence of chronic pain among adults in the United States

R. Jason Yong et al.

Summary: Chronic pain is associated with reduced quality of life, increased medical expenditures, and significant economic costs. According to the latest data, more than one-fifth of adults in America experience chronic pain, indicating a need for increased attention and management.
Review Genetics & Heredity

The emerging landscape of spatial profiling technologies

Jeffrey R. Moffitt et al.

Summary: Improved scale, multiplexing and resolution of spatial nucleic acid and protein profiling methods have established them as a major component of cellular atlas building. These methods enable measurements at nano- to microscale resolutions, allowing the study of cellular heterogeneity, tissue architectures, and dynamic changes during development and disease. This review provides an overview of the emerging landscape of in situ spatial genome, transcriptome, and proteome technologies, highlighting their impact on cell biology and translational research.

NATURE REVIEWS GENETICS (2022)

Article Multidisciplinary Sciences

Conservation and divergence of cortical cell organization in human and mouse revealed by MERFISH

Rongxin Fang et al.

Summary: This study used MERFISH to perform single-cell profiling of the human cerebral cortex, identifying over 100 different cell types and generating a cell atlas of the middle and superior temporal gyrus. Comparison with the mouse cortex revealed conservation in cell laminar organization and differences in cell-cell interactions across species.

SCIENCE (2022)

Article Biology

Local field potentials reflect cortical population dynamics in a region-specific and frequency-dependent manner

Cecilia Gallego-Carracedo et al.

Summary: This study investigates the relationship between latent dynamics and local field potentials (LFPs), and finds that this relationship remains stable throughout behavior, bridging the gap between studies on neural correlates of behavior using different types of recordings.

ELIFE (2022)

Article Multidisciplinary Sciences

Accurate inference of genome-wide spatial expression with iSpatial

Chao Zhang et al.

Summary: The new algorithm iSpatial developed in this study can derive the spatial pattern of the entire transcriptome at single-cell resolution. Compared to other methods, iSpatial has higher accuracy in predicting gene expression and spatial distribution, and reduces false-positive and false-negative signals.

SCIENCE ADVANCES (2022)

Article Biotechnology & Applied Microbiology

Cell type prioritization in single-cell data

Michael A. Skinnider et al.

Summary: The Augur method can effectively identify the cell types most responsive to biological perturbations in single-cell data, helping to explore the relationship between gene expression changes and biological functions.

NATURE BIOTECHNOLOGY (2021)

Article Biochemistry & Molecular Biology

Differential encoding in prefrontal cortex projection neuron classes across cognitive tasks

Jan H. Lui et al.

Summary: Single-cell transcriptomics has been used to classify neurons in the mammalian brain, and in this study, researchers examined how specific transcriptomic types of mouse prefrontal cortex (PFC) projection neurons are related to axonal projections and encoding properties across multiple cognitive tasks. They found that most types of neurons projected to multiple targets, and that task signals are organized redundantly but with clear quantitative biases across cells of specific molecular-anatomical characteristics.
Article Multidisciplinary Sciences

An atlas of gene regulatory elements in adult mouse cerebrum

Yang Eric Li et al.

Summary: Recent studies have identified hundreds of neural cell types in different brain regions of mice and humans, but the transcriptional regulatory programs responsible for the unique identity and function of each cell type remain unknown. By analyzing the chromatin accessibility in individual nuclei from various brain regions, researchers have mapped candidate cis-regulatory DNA elements in distinct cell types, providing insights into the gene regulatory programs of the mammalian brain.

NATURE (2021)

Article Multidisciplinary Sciences

A multimodal cell census and atlas of the mammalian primary motor cortex

Edward M. Callaway et al.

Summary: This study presents a multimodal cell census and atlas of the mammalian primary motor cortex, integrating various molecular and spatial information to reveal a unified genetic landscape of cortical cell types. The results establish a mechanistic framework of neuronal cell-type organization by linking molecular genetic information with phenotypic properties.

NATURE (2021)

Article Multidisciplinary Sciences

Spatially resolved cell atlas of the mouse primary motor cortex by MERFISH

Meng Zhang et al.

Summary: A single-cell transcriptome-imaging method, MERFISH, was used to create a molecularly defined and spatially resolved cell atlas of the mouse primary motor cortex. Approximately 300,000 cells were profiled, revealing 95 neuronal and non-neuronal cell clusters and a complex spatial map. Integration of MERFISH with retrograde labelling showed that cortical projections from neurons formed a complex network with individual clusters projecting to multiple target regions.

NATURE (2021)

Article Neurosciences

Decoding molecular and cellular heterogeneity of mouse nucleus accumbens

Renchao Chen et al.

Summary: The authors utilized single-cell RNA sequencing and multiplexed error-robust FISH to generate a cell census of the mouse nucleus accumbens, revealing a high level of cell heterogeneity. This study demonstrates that the transcriptional and spatial diversity of neuron subtypes underlie the anatomic and functional heterogeneity of the nucleus accumbens.

NATURE NEUROSCIENCE (2021)

Review Neurosciences

Prefrontal Cortex Development in Health and Disease: Lessons from Rodents and Humans

Mattia Chini et al.

Summary: The prefrontal cortex (PFC) plays a crucial role in enabling sophisticated cognitive and social abilities in humans, but also underlies some psychiatric disorders. Developmental contributions of molecules and electrical activity are essential for the maturation and functioning of the PFC.

TRENDS IN NEUROSCIENCES (2021)

Review Neurosciences

Differential Rearrangement of Excitatory Inputs to the Medial Prefrontal Cortex in Chronic Pain Models

Taylor Jefferson et al.

Summary: Chronic pain patients not only suffer from the pain itself, but also from accompanying symptoms such as depression and anxiety, with the heterogeneity of these symptoms supporting the significant involvement of the cerebral cortex in chronic pain conditions. Research demonstrates that the activity of the medial prefrontal cortex (mPFC) is severely impaired in chronic pain, with excitability depending on integrated effects of intrinsic excitability and excitatory and inhibitory inputs. Furthermore, extracortical sources of excitatory input to the mPFC, such as the thalamus, hippocampus, and amygdala, play a crucial role in integrating multiple information streams necessary for cognitive control of pain.

FRONTIERS IN NEURAL CIRCUITS (2021)

Review Neurosciences

Circuit organization of the rodent medial cortex

Paul G. Anastasiades et al.

Summary: This review focuses on the cellular diversity of rodent mPFC, the impact of long-range inputs, and the specificity of local microcircuits, as well as similarities with and differences from other cortical areas, illustrating how the circuit organization of mPFC may contribute to its unique functional roles.

TRENDS IN NEUROSCIENCES (2021)

Article Biochemistry & Molecular Biology

Integrated analysis of multimodal single-cell data

Yuhan Hao et al.

Summary: The study introduces a weighted-nearest neighbor analysis framework to learn the relative utility of each data type in each cell, enabling integrative analysis of multiple modalities. Applied to a CITE-seq dataset, the method constructs a multimodal reference atlas of the circulating immune system and successfully identifies and validates previously unreported lymphoid subpopulations.
Review Neurosciences

Neocortical circuits in pain and pain relief

Linette Liqi Tan et al.

Summary: This review examines the role of neocortical circuits in providing specificity and causality to pain perception. Sensory, associative, and limbic neocortical structures play a critical role in shaping pain perception, with technological advances enabling a better understanding of the mechanisms involved. The insights gained from studying neocortical pain processing have the potential for therapeutic interventions to improve pain management.

NATURE REVIEWS NEUROSCIENCE (2021)

Article Multidisciplinary Sciences

SNP rs10420324 in the AMPA receptor auxiliary subunit TARP γ-8 regulates the susceptibility to antisocial personality disorder

Shi-Xiao Peng et al.

Summary: TARP gamma-8 expression level is associated with antisocial personality disorder (ASPD), and rs10420324G in CACNG8 is more susceptible to ASPD. Decreased TARP gamma-8 expression in mice leads to behavioral abnormalities similar to ASPD patients, partially explaining the neuronal basis for ASPD.

SCIENTIFIC REPORTS (2021)

Article Clinical Neurology

Frequency Dependent Electrical Stimulation of PFC and ACC for Acute Pain Treatment in Rats

Yaling Liu et al.

Summary: Low-frequency stimulation in the PL-PFC can reduce sensory and affective pain components, while high-frequency stimulation of the ACC reduces pain aversive behaviors. This suggests that frequency-dependent neuromodulation of the PFC or ACC has the potential for pain modulation.

FRONTIERS IN PAIN RESEARCH (2021)

Review Cell Biology

Emerging role of AMPA receptor subunit GluA1 in synaptic plasticity: Implications for Alzheimer's disease

Wenrui Qu et al.

Summary: The role of GluA1-mediated synaptic plasticity in the early development of AD is well established, but the complex mechanisms involved are not fully understood. Deficits in synaptic plasticity are a central factor of AD etiology, and understanding the role of GluA1 and its regulatory mechanisms is crucial for developing disease-modifying therapies.

CELL PROLIFERATION (2021)

Article Biochemistry & Molecular Biology

The Allen Mouse Brain Common Coordinate Framework: A 3D Reference Atlas

Quanxin Wang et al.

Review Neurosciences

Role of the Prefrontal Cortex in Pain Processing

Wei-Yi Ong et al.

MOLECULAR NEUROBIOLOGY (2019)

Editorial Material Clinical Neurology

Calcium Channel Dysfunction in Epilepsy: Gain of CACNA1E

Gemma L. Carvill

EPILEPSY CURRENTS (2019)

Article Biochemistry & Molecular Biology

Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data

Samuel L. Wolock et al.

CELL SYSTEMS (2019)

Review Biochemistry & Molecular Biology

Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders

Arturo Andrade et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemical Research Methods

Fast, sensitive and accurate integration of single-cell data with Harmony

Ilya Korsunsky et al.

NATURE METHODS (2019)

Article Multidisciplinary Sciences

Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction

Aritra Bhattacherjee et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

An amygdalar neural ensemble that encodes the unpleasantness of pain

Gregory Corder et al.

SCIENCE (2019)

Article Multidisciplinary Sciences

Single-cell transcriptomic analysis of mouse neocortical development

Lipin Loo et al.

NATURE COMMUNICATIONS (2019)

Article Neurosciences

A novel neuromodulation strategy to enhance the prefrontal control to treat pain

Haocheng Zhou et al.

MOLECULAR PAIN (2019)

Article Multidisciplinary Sciences

From Louvain to Leiden: guaranteeing well-connected communities

V. A. Traag et al.

SCIENTIFIC REPORTS (2019)

Article Neurosciences

An interactive framework for whole-brain maps at cellular resolution

Daniel Furth et al.

NATURE NEUROSCIENCE (2018)

Article Neurosciences

Ionic Mechanism Underlying Rebound Depolarization in Medial Prefrontal Cortex Pyramidal Neurons

Przemyslaw Kurowski et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Review Anatomy & Morphology

Layer- and Cell Type-Specific Modulation of Excitatory Neuronal Activity in the Neocortex

Gabriele Radnikow et al.

FRONTIERS IN NEUROANATOMY (2018)

Article Cell Biology

Scaling Up Cortical Control Inhibits Pain

Jahrane Dale et al.

CELL REPORTS (2018)

Article Multidisciplinary Sciences

Shared and distinct transcriptomic cell types across neocortical areas

Bosiljka Tasic et al.

NATURE (2018)

Article Multidisciplinary Sciences

Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region

Jeffrey R. Moffitt et al.

SCIENCE (2018)

Review Neurosciences

Neuronal cell-type classification: challenges, opportunities and the path forward

Hongkui Zeng et al.

NATURE REVIEWS NEUROSCIENCE (2017)

Article Biochemistry & Molecular Biology

Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression

Giannina Descalzi et al.

SCIENCE SIGNALING (2017)

Article Biochemistry & Molecular Biology

Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression

Giannina Descalzi et al.

SCIENCE SIGNALING (2017)

Review Neurosciences

Prefrontal Cortical Opioids and Dysregulated Motivation: A Network Hypothesis

Brian A. Baldo

TRENDS IN NEUROSCIENCES (2016)

Review Neurosciences

Local Field Potentials: Myths and Misunderstandings

Oscar Herreras

FRONTIERS IN NEURAL CIRCUITS (2016)

Review Neurosciences

The neocortical circuit: themes and variations

Kenneth D. Harris et al.

NATURE NEUROSCIENCE (2015)

Article Multidisciplinary Sciences

Spatially resolved, highly multiplexed RNA profiling in single cells

Kok Hao Chen et al.

SCIENCE (2015)

Editorial Material Health Care Sciences & Services

Editorial, supportive care and psychological issues around cancer

Elie Isenberg-Grzeda et al.

CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE (2015)

Review Biochemical Research Methods

Neuronal and Cardiovascular Potassium Channels as Therapeutic Drug Targets: Promise and Pitfalls

Edward S. A. Humphries et al.

JOURNAL OF BIOMOLECULAR SCREENING (2015)

Article Biochemical Research Methods

Causal analysis approaches in Ingenuity Pathway Analysis

Andreas Kraemer et al.

BIOINFORMATICS (2014)

Article Biochemistry & Molecular Biology

Neural Networks of the Mouse Neocortex

Brian Zingg et al.

Article Neurosciences

Mechanisms by which a CACNA1H mutation in epilepsy patients increases seizure susceptibility

Veit-Simon Eckle et al.

JOURNAL OF PHYSIOLOGY-LONDON (2014)

Review Neurosciences

Pain vulnerability: a neurobiological perspective

Franziska Denk et al.

NATURE NEUROSCIENCE (2014)

Review Health Care Sciences & Services

Descending pain modulation and chronification of pain

Michael H. Ossipov et al.

CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE (2014)

Review Neurosciences

Central Mechanisms of Pain Revealed Through Functional and Structural MRI

Karen D. Davis et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2013)

Review Neurosciences

Cognitive and emotional control of pain and its disruption in chronic pain

M. Catherine Bushnell et al.

NATURE REVIEWS NEUROSCIENCE (2013)

Article Neurosciences

The role of GluA 1 in central nervous system disorders

Jingli Zhang et al.

REVIEWS IN THE NEUROSCIENCES (2013)

Article Clinical Neurology

The Economic Costs of Pain in the United States

Darrell J. Gaskin et al.

JOURNAL OF PAIN (2012)

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Article Biochemical Research Methods

pROC: an open-source package for R and S plus to analyze and compare ROC curves

Xavier Robin et al.

BMC BIOINFORMATICS (2011)

Article Medicine, Research & Experimental

A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia

Sabrina Grube et al.

EMBO MOLECULAR MEDICINE (2011)

Article Multidisciplinary Sciences

The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice

Mette Richner et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2011)

Article Biochemistry & Molecular Biology

CACNA1H mutations in autism spectrum disorders

Igor Splawski et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Neurosciences

The distribution and targeting of neuronal voltage-gated ion channels

Helen C. Lai et al.

NATURE REVIEWS NEUROSCIENCE (2006)

Review Behavioral Sciences

Cannabinoids and prefrontal cortical function: Insights from preclinical studies

Alice Egerton et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2006)

Review Neurosciences

Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers

PLA Gabbott et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2005)

Review Neurosciences

An integrative theory of prefrontal cortex function

EK Miller et al.

ANNUAL REVIEW OF NEUROSCIENCE (2001)