☆ 4.8 Review

Biological and functional multimorbidity-from mechanisms to management

NATURE MEDICINE (2023)

Related references

Note: Only part of the references are listed.

Letter Gastroenterology & Hepatology

Global prediction of primary liver cancer incidences and mortality in 2040

Chenxi Li et al.

JOURNAL OF HEPATOLOGY (2023)

Add to Collection

Article Biochemistry & Molecular Biology

The impact of the COVID-19 pandemic on cardiovascular disease prevention and management

Caroline E. Dale et al.

Summary: The COVID-19 pandemic has had an impact on the prevention and management of cardiovascular disease. Using medication data, this study analyzed the dispensing of cardiovascular medications in England, Scotland, and Wales. The findings showed a decline in the use of antihypertensive and lipid-lowering medications, while the use of medications for type 2 diabetes increased. Urgent measures are needed to identify and treat individuals who have missed treatment for cardiovascular risk factors.

NATURE MEDICINE (2023)

Add to Collection

Article Cardiac & Cardiovascular Systems

Cardiovascular disease and mortality sequelae of COVID-19 in the UK Biobank

Zahra Raisi-Estabragh et al.

Summary: This study investigated the association between COVID-19 cases in the UK Biobank and incident cardiovascular events. The results showed that hospitalized COVID-19 patients had an increased risk of various cardiovascular events, and non-hospitalized patients had an increased risk of venous thromboembolism.

HEART (2023)

Add to Collection

Article Genetics & Heredity

Network expansion of genetic associations defines a pleiotropy map of human cell biology

Inigo Barrio-Hernandez et al.

Summary: Interacting proteins with similar functions influence organismal traits. Network-based expansion of trait-associated genes for 1,002 human traits recovers known disease genes or drug targets, identifies groups of traits with shared genetic and biological processes, and uncovers pleiotropic gene modules associated with multiple traits. This study demonstrates potential opportunities for drug repurposing and development.

NATURE GENETICS (2023)

Add to Collection

Article Endocrinology & Metabolism

Proteogenomic links to human metabolic diseases

Mine Koprulu et al.

Summary: Studying the plasma proteome can help identify new disease processes. In this study, a cis-focused proteogenomic analysis was conducted on plasma proteins from 1,180 individuals, revealing unreported protein quantitative trait loci (pQTL). Shared genetic regulation between pQTLs and health outcomes, improved gene assignment at risk loci, and convergence of phenotypic consequences and gene burden were observed. These findings highlight the value of integrating proteomic and genomic data to identify mediators of metabolic diseases.

NATURE METABOLISM (2023)

Add to Collection

Editorial Material Pharmacology & Pharmacy

Longitudinal Analysis Suggests Epstein--Barr as Cause of Multiple Sclerosis

[Anonymous]

CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)

Add to Collection

Article Medicine, General & Internal

Obesity and risk of female reproductive conditions: A Mendelian randomisation study

Samvida S. Venkatesh et al.

Summary: This study analyzed data on obesity and reproductive diseases in women of European ancestry and found that obesity is associated with increased risks of various reproductive disorders, including uterine fibroids, polycystic ovary syndrome, heavy menstrual bleeding, and pre-eclampsia. The study also identified associations between obesity, metabolic hormones, and reproductive diseases, and found that the relationship between obesity and reproductive disorders is influenced by genetic factors.

PLOS MEDICINE (2022)

Add to Collection

Review Medicine, General & Internal

Variation in the estimated prevalence of multimorbidity: systematic review and meta-analysis of 193 international studies

Iris Szu-Szu Ho et al.

Summary: The objective of this study was to estimate the pooled prevalence of multimorbidity in all age groups globally and to examine how measurement of multimorbidity impacted the estimated prevalence. The study found that the pooled prevalence of multimorbidity was significantly higher in older populations and when studies included a larger number of baseline conditions.

BMJ OPEN (2022)

Add to Collection

Article Medicine, General & Internal

Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease

Kiran J. Biddinger et al.

Summary: Observational studies have suggested cardiovascular benefits associated with light alcohol consumption, while genetic analyses have indicated a possible causal link between alcohol intake and increased cardiovascular disease risk. This cohort study using the UK Biobank examined the association of habitual alcohol intake with cardiovascular disease risk, showing that light to moderate alcohol consumption was associated with healthier lifestyle factors, but genetic predisposition to alcohol intake was associated with increased risk of hypertension and coronary artery disease across different levels of intake.

JAMA NETWORK OPEN (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Rare and common genetic determinants of metabolic individuality and their effects on human health

Praveen Surendran et al.

Summary: Garrod's concept of 'chemical individuality' contributes to understanding the molecular origins of human diseases. The genetic architecture of the human plasma metabolome was studied using high-throughput metabolomic technologies, revealing associations between genetic variants and metabolite levels.

NATURE MEDICINE (2022)

Add to Collection

Review Endocrinology & Metabolism

The burden and risks of emerging complications of diabetes mellitus

Dunya Tomic et al.

Summary: The traditional complications of diabetes mellitus have been well-known, but emerging evidence suggests the existence of a different set of complications. Cancer and dementia have become the leading causes of death in people with diabetes, replacing vascular disease. Additionally, diabetes has been linked to a range of comorbidities, including cognitive decline, functional disability, affective disorders, obstructive sleep apnoea, and liver disease. There is currently no comprehensive review summarizing the burden and risks of these emerging complications.

NATURE REVIEWS ENDOCRINOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19

Maik Pietzner et al.

Summary: This study integrates genomic, proteomic, and single-cell data to identify ELF5 as a candidate risk gene for severe COVID-19. ELF5 shows consistent associations with different outcome definitions and is specifically expressed in respiratory epithelial cells, which are likely targets of SARS-CoV-2.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Medicine, General & Internal

Multimorbidity

Soren T. Skou et al.

Summary: Multimorbidity has substantial effects on individuals, carers and society. The mechanisms underlying its development are complex and related to ageing and broader determinants of health. Little is known about prevention, but interventions focusing on psychosocial and behavioral factors are likely to be beneficial. Most clinical guidelines and healthcare training focus on single diseases, whereas multimorbidity requires person-centered care.

NATURE REVIEWS DISEASE PRIMERS (2022)

Add to Collection

Article Medical Informatics

COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records

Johan H. Thygesen et al.

Summary: This study used nationwide linked electronic health records to define and validate ten COVID-19 phenotypes, providing insights into the different stages and transitions of the disease. The results showed infection rates, hospitalization rates, intensive care unit usage, and mortality rates of COVID-19. Longer patient trajectories were observed in the second wave compared to the first wave.

LANCET DIGITAL HEALTH (2022)

Add to Collection

Article Multidisciplinary Sciences

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

Kjetil Bjornevik et al.

Summary: This study suggests that multiple sclerosis may be caused by Epstein-Barr virus, with no direct association with other viral infections. These findings provide clues to the primary cause of MS.

SCIENCE (2022)

Add to Collection

Article Genetics & Heredity

A cross-platform approach identifies genetic regulators of human metabolism and health

Luca A. Lotta et al.

Summary: By conducting a cross-platform analysis of metabolites, we identified various genetic regulators associated with metabolite levels, including their impact on diseases such as type 2 diabetes and macular telangiectasia type 2.

NATURE GENETICS (2021)

Add to Collection

Article Genetics & Heredity

Large-scale integration of the plasma proteome with genetics and disease

Egil Ferkingstad et al.

Summary: Genome-wide association studies of plasma protein levels in Icelanders have identified numerous associations with diseases and other traits, providing valuable insights into disease pathogenesis and potential drug targets. Through integration of proteomics, genomics, and transcriptomics, this research offers a resource for improving disease understanding and aiding drug discovery and development.

NATURE GENETICS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Plasma metabolites to profile pathways in noncommunicable disease multimorbidity

Maik Pietzner et al.

Summary: The study identified shared pathways contributing to the multimorbidity of noncommunicable diseases using untargeted metabolomics profiling and integrated various risk factors and characteristics to identify actionable shared pathways.

NATURE MEDICINE (2021)

Add to Collection

Article Multidisciplinary Sciences

Mapping the proteo-genomic convergence of human diseases

Maik Pietzner et al.

Summary: The study identified genetic associations for plasma proteins and established a map connecting genes, proteins, and diseases, highlighting biological convergence across diseases. This proteo-genomic map helps to understand relationships between diseases and provide biological context for emerging disorders.

SCIENCE (2021)

Add to Collection

Article Multidisciplinary Sciences

A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits

Christopher N. Foley et al.

Summary: Genome-wide association studies have identified thousands of genomic regions affecting complex diseases. The authors propose HyPrColoc, an efficient Bayesian clustering algorithm, to detect colocalized traits from large numbers of traits. This method can be used to identify causal genes and shared genetic aetiology across traits.

NATURE COMMUNICATIONS (2021)

Add to Collection

Review Public, Environmental & Occupational Health

Examining variation in the measurement of multimorbidity in research: a systematic review of 566 studies

Iris Szu-Szu Ho et al.

Summary: This review examined the definition and measurement of multimorbidity in international peer-reviewed studies, finding a high variability in both aspects. Consistent reporting of measure definitions should be required by journals, and consensus studies are needed to define core and study-dependent conditions to include in measures of multimorbidity.

LANCET PUBLIC HEALTH (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Exploiting the GTEx resources to decipher the mechanisms at GWAS loci

Alvaro N. Barbeira et al.

Summary: The resources generated by the GTEx consortium provide unprecedented opportunities to advance understanding of human diseases. The study demonstrates widespread dose-dependent effects of RNA expression and splicing on complex traits and diseases, proposes a combination of methods to prioritize causal genes, and identifies potential target genes for over half of the GWAS loci examined.

GENOME BIOLOGY (2021)

Add to Collection

Review Pharmacology & Pharmacy

The long and winding road in pharmaceutical development of canakinumab from rare genetic autoinflammatory syndromes to myocardial infarction and cancer

Hermann Gram

PHARMACOLOGICAL RESEARCH (2020)

Add to Collection

Review Cardiac & Cardiovascular Systems

Association between clinical risk scores and mortality in atrial fibrillation: Systematic review and network meta-regression of 669,000 patients

Marco Proietti et al.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2020)

Add to Collection

Article Public, Environmental & Occupational Health

Association between socioeconomic status and the development of mental and physical health conditions in adulthood: a multi-cohort study

Mika Kivimaki et al.

LANCET PUBLIC HEALTH (2020)

Add to Collection

Editorial Material Medicine, General & Internal

Rising to the challenge of multimorbidity

Christopher J. M. Whitty et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

Add to Collection

Editorial Material Multidisciplinary Sciences

Map clusters of diseases to tackle multimorbidity

Christopher J. M. Whitty et al.

NATURE (2020)

Add to Collection

Review Cardiac & Cardiovascular Systems

SGLT2 inhibitors: mechanisms of cardiovascular benefit beyond glycaemic control

Martin R. Cowie et al.

NATURE REVIEWS CARDIOLOGY (2020)

Add to Collection

Article Genetics & Heredity

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

Jie Zheng et al.

NATURE GENETICS (2020)

Add to Collection

Letter Rheumatology

Genetic variants mimicking therapeutic inhibition of IL-6 receptor signaling and risk of COVID-19

Jonas Bovijn et al.

LANCET RHEUMATOLOGY (2020)

Add to Collection

Article Endocrinology & Metabolism

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Lasse Folkersen et al.

NATURE METABOLISM (2020)

Add to Collection

Review Genetics & Heredity

Genetic correlations of polygenic disease traits: from theory to practice

Wouter van Rheenen et al.

NATURE REVIEWS GENETICS (2019)

Add to Collection

Article Multidisciplinary Sciences

Improving the odds of drug development success through human genomics: modelling study

Aroon D. Hingorani et al.

SCIENTIFIC REPORTS (2019)

Add to Collection

Article Genetics & Heredity

Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval

Emily A. King et al.

PLOS GENETICS (2019)

Add to Collection

Review Biotechnology & Applied Microbiology

Drug repurposing: progress, challenges and recommendations

Sudeep Pushpakom et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Add to Collection

Article Geriatrics & Gerontology

Projections of multi-morbidity in the older population in England to 2035: estimates from the Population Ageing and Care Simulation (PACSim) model

Andrew Kingston et al.

AGE AND AGEING (2018)

Add to Collection

Article Gastroenterology & Hepatology

Variation in Interleukin 6 Receptor Gene Associates With Risk of Crohn's Disease and Ulcerative Colitis

Constantinos A. Parisinos et al.

GASTROENTEROLOGY (2018)

Add to Collection

Article Medicine, General & Internal

Melioidosis

W. Joost Wiersinga et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

Add to Collection

Article Cardiac & Cardiovascular Systems

Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus A Mendelian Randomization Analysis

Caroline E. Dale et al.

CIRCULATION (2017)

Add to Collection

Editorial Material Medicine, General & Internal

GUIDELINES Clinical assessment and management of multimorbidity: summary of NICE guidance

Caroline Farmer et al.

BMJ-BRITISH MEDICAL JOURNAL (2016)

Add to Collection

Editorial Material Medicine, General & Internal

GUIDELINES Clinical assessment and management of multimorbidity: summary of NICE guidance

Caroline Farmer et al.

BMJ-BRITISH MEDICAL JOURNAL (2016)

Add to Collection

Article Education, Scientific Disciplines

Long-term risk of second malignancy and cardiovascular disease after Hodgkin lymphoma treatment

Flora E. van Leeuwen et al.

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2016)

Add to Collection

Article Genetics & Heredity

The support of human genetic evidence for approved drug indications

Matthew R. Nelson et al.

NATURE GENETICS (2015)

Add to Collection

Article Multidisciplinary Sciences

Genetics of rheumatoid arthritis contributes to biology and drug discovery

Yukinori Okada et al.

NATURE (2014)

Add to Collection

Article Biotechnology & Applied Microbiology

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

David Cook et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Add to Collection

Article Medicine, General & Internal

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

Michael V. Holmes et al.

BMJ-BRITISH MEDICAL JOURNAL (2014)

Add to Collection

Article Genetics & Heredity

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

Claudia Giambartolomei et al.

PLOS GENETICS (2014)

Add to Collection

Article Cardiac & Cardiovascular Systems

Interleukin-6 receptor pathways in abdominal aortic aneurysm

Seamus C. Harrison et al.

EUROPEAN HEART JOURNAL (2013)

Add to Collection

Article Genetics & Heredity

Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases

Ricardo C. Ferreira et al.

PLOS GENETICS (2013)

Add to Collection

Article Medicine, General & Internal

Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study

Karen Barnett et al.

LANCET (2012)

Add to Collection

Article Medicine, General & Internal

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

Daniel I. Swerdlow et al.

LANCET (2012)

Add to Collection

Article Medicine, General & Internal

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

JC Cohen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Add to Collection

Article Medicine, General & Internal

Adverse drug reactions as cause of admission to hospital: prospective analysis of 18,820 patients

M Pirmohamed et al.

BMJ-BRITISH MEDICAL JOURNAL (2004)

Add to Collection

© Peeref 2019-2024. All rights reserved.