Stem-cell-like CD4(+) T cells prey on MHC class II-negative tumors

Despite the absence of MHC class II molecules on tumor cells, stem-cell-like CD4(+) T cells specific for tumor neoantigens can mediate profound antitumor effects by licensing antigen-presenting cells and augmenting antitumor CD8(+) T cells in the tumor microenvironment and draining lymph nodes.

Automated summary

Despite the absence of MHC class II molecules on tumor cells, stem-cell-like CD4(+) T cells specific for tumor neoantigens can enhance the antitumor effects by interacting with antigen-presenting cells and promoting antitumor CD8(+) T cells in the tumor microenvironment and draining lymph nodes.