Related references
Note: Only part of the references are listed.APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints
Zhuoran Yin et al.
NATURE IMMUNOLOGY (2023)
Specification of CNS macrophage subsets occurs postnatally in defined niches
Takahiro Masuda et al.
NATURE (2022)
ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias
Yuka A. Martens et al.
NEURON (2022)
ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies
Ana-Caroline Raulin et al.
MOLECULAR NEURODEGENERATION (2022)
Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function
Chia-Chen Liu et al.
NATURE NEUROSCIENCE (2022)
APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases
Rosalia Fernandez-Calle et al.
MOLECULAR NEURODEGENERATION (2022)
A reference human induced pluripotent stem cell line for collaborative studies
Caroline B. Pantazis et al.
CELL STEM CELL (2022)
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
Fangda Leng et al.
NATURE REVIEWS NEUROLOGY (2021)
Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation
Maria Fe Lanfranco et al.
GLIA (2021)
APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia
Chia-Chen Liu et al.
SCIENCE TRANSLATIONAL MEDICINE (2021)
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia
Grzegorz Sienski et al.
SCIENCE TRANSLATIONAL MEDICINE (2021)
TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation
Lorenza Magno et al.
MOLECULAR NEURODEGENERATION (2021)
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia
Chao Wang et al.
NEURON (2021)
Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration
Xin Ding et al.
NATURE COMMUNICATIONS (2021)
Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids
Jing Zhao et al.
ACTA NEUROPATHOLOGICA (2021)
Microglia in Alzheimer's disease at single-cell level. Are there common in humans and mice?
Yun Chen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2021)
Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer's disease brains
Md Golam Sharoar et al.
MOLECULAR NEURODEGENERATION (2021)
Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration
Henry Querfurth et al.
MOLECULAR NEURODEGENERATION (2021)
mTOR-dependent translation amplifies microglia priming in aging mice (vol 131, pg 1, 2021)
Lily Keane et al.
JOURNAL OF CLINICAL INVESTIGATION (2021)
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
Julia Marschallinger et al.
NATURE NEUROSCIENCE (2020)
APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease
Aivi T. Nguyen et al.
ACTA NEUROPATHOLOGICA (2020)
Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice
Nicholas F. Fitz et al.
MOLECULAR NEURODEGENERATION (2020)
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Tiantian Guo et al.
MOLECULAR NEURODEGENERATION (2020)
Novel Hexb-based tools for studying microglia in the CNS
Takahiro Masuda et al.
NATURE IMMUNOLOGY (2020)
Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease
Shun-Fat Lau et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease
Marta Olah et al.
NATURE COMMUNICATIONS (2020)
Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease
Antonio Boza-Serrano et al.
ACTA NEUROPATHOLOGICA (2019)
The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques
Carlo Sala Frigerio et al.
CELL REPORTS (2019)
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma
Cyril Neftel et al.
CELL (2019)
A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease
Sung Hoon Baik et al.
CELL METABOLISM (2019)
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies
Yu Yamazaki et al.
NATURE REVIEWS NEUROLOGY (2019)
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model
Yang Shi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2019)
Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model
Tien-Phat V. Huynh et al.
MOLECULAR NEURODEGENERATION (2019)
Fast, sensitive and accurate integration of single-cell data with Harmony
Ilya Korsunsky et al.
NATURE METHODS (2019)
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
Samira Parhizkar et al.
NATURE NEUROSCIENCE (2019)
Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration
Aleksandra Deczkowska et al.
CELL (2018)
ApoE facilitates the microglial response to amyloid plaque pathology
Jason D. Ulrich et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2018)
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Andrew Butler et al.
NATURE BIOTECHNOLOGY (2018)
Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau
Silvia S. Kang et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2018)
Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight
Yang Shi et al.
NATURE REVIEWS IMMUNOLOGY (2018)
APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes
Jing Zhao et al.
HUMAN MOLECULAR GENETICS (2017)
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
Susanne Krasemann et al.
IMMUNITY (2017)
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
Yang Shi et al.
NATURE (2017)
Neurotoxic reactive astrocytes are induced by activated microglia
Shane A. Liddelow et al.
NATURE (2017)
iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases
Edsel M. Abud et al.
NEURON (2017)
ApoE4 Accelerates Early Seeding of Amyloid Pathology
Chia-Chen Liu et al.
NEURON (2017)
Aging Microglia-Phenotypes, Functions and Implications for Age-Related Neurodegenerative Diseases
Bjoern Spittau
FRONTIERS IN AGING NEUROSCIENCE (2017)
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease
Hadas Keren-Shaul et al.
CELL (2017)
New insights on the role of microglia in synaptic pruning in health and disease
Soyon Hong et al.
CURRENT OPINION IN NEUROBIOLOGY (2016)
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
Yaming Wang et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2016)
Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease
Hong Lian et al.
JOURNAL OF NEUROSCIENCE (2016)
Origin, fate and dynamics of macrophages at central nervous system interfaces
Tobias Goldmann et al.
NATURE IMMUNOLOGY (2016)
Microglial brain region-dependent diversity and selective regional sensitivities to aging
Kathleen Grabert et al.
NATURE NEUROSCIENCE (2016)
Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease
Chia-Chen Liu et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer's Disease Model
Yaming Wang et al.
CELL (2015)
Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
Yuka Atagi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Receptors, Ion Channels, and Signaling Mechanisms Underlying Microglial Dynamics
Christian Madry et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques
Carlo Condello et al.
NATURE COMMUNICATIONS (2015)
Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer's Disease
Chia-Chen Liu et al.
NEURON (2014)
Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor
Christopher N. Parkhurst et al.
CELL (2013)
The quad-partite synapse: Microglia-synapse interactions in the developing and mature CNS
Dorothy P. Schafer et al.
GLIA (2013)
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Chia-Chan Liu et al.
NATURE REVIEWS NEUROLOGY (2013)
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Dorothy P. Schafer et al.
NEURON (2012)
Age-related alterations in the dynamic behavior of microglia
Mausam R. Damani et al.
AGING CELL (2011)
Pathogenic Protein Seeding in Alzheimer Disease and Other Neurodegenerative Disorders
Mathias Jucker et al.
ANNALS OF NEUROLOGY (2011)
Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance
Joseph M. Castellano et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
IFN-γ Promotes Complement Expression and Attenuates Amyloid Plaque Deposition in Amyloid β Precursor Protein Transgenic Mice
Paramita Chakrabarty et al.
JOURNAL OF IMMUNOLOGY (2010)
Chronic optical access through a polished and reinforced thinned skull
Patrick J. Drew et al.
NATURE METHODS (2010)
Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice
Kishore V. Kuchibhotla et al.
SCIENCE (2009)
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
Bahareh Ajami et al.
NATURE NEUROSCIENCE (2007)
A clonogenic bone marrow progenitor specific for macrophages and dendritic cells
DK Fogg et al.
SCIENCE (2006)
Development of a single-cassette system for spatiotemporal gene regulation in mice
S Miyazaki et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
A Subramanian et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
ATP mediates rapid microglial response to local brain injury in vivo
D Davalos et al.
NATURE NEUROSCIENCE (2005)
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
A Nimmerjahn et al.
SCIENCE (2005)
Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo:: evidence for augmentation of a 42-specific γ secretase
JL Jankowsky et al.
HUMAN MOLECULAR GENETICS (2004)
Protein aggregation and neurodegenerative disease
CA Ross et al.
NATURE MEDICINE (2004)
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
DM Holtzman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)