Related references
Note: Only part of the references are listed.Nivolumab and Relatlimab in Patients With Advanced Melanoma That Had Progressed on Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy: Results From the Phase I/IIa RELATIVITY-020 Trial
Paolo Antonio Ascierto et al.
JOURNAL OF CLINICAL ONCOLOGY (2023)
LAG3 pushes immuno-oncology's leading edge
Asher Mullard
NATURE REVIEWS DRUG DISCOVERY (2022)
Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma
Hussein A. Tawbi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2022)
Immune Checkpoint LAG3 and Its Ligand FGL1 in Cancer
An-Ping Shi et al.
FRONTIERS IN IMMUNOLOGY (2022)
The Immune Checkpoint Inhibitor LAG-3 and Its Ligand GAL-3 in Vulvar Squamous Neoplasia
Margaret M. Cocks et al.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY (2022)
Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity
Takumi Maruhashi et al.
IMMUNITY (2022)
Targeting LAG3/GAL-3 to overcome immunosuppression and enhance anti-tumor immune responses in multiple myeloma
Jooeun Bae et al.
LEUKEMIA (2022)
LAG3 associates with TCR-CD3 complexes and suppresses signaling by driving co-receptor-Lck dissociation
Clifford Guy et al.
NATURE IMMUNOLOGY (2022)
Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3
Stephanie Grebinoski et al.
NATURE IMMUNOLOGY (2022)
LAG3 disrupts the TCR signal by local acidification
Claire Hivroz
NATURE IMMUNOLOGY (2022)
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition
Qianqian Ming et al.
NATURE IMMUNOLOGY (2022)
Lymphocyte Activation Gene 3 (Lag3) Contributes to α-Synucleinopathy in α-Synuclein Transgenic Mice
Hao Gu et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2021)
Phenotypic and Functional Analyses Guiding Combination Immune Checkpoint Immunotherapeutic Strategies in HTLV-1 Infection
Danielle M. Clements et al.
FRONTIERS IN IMMUNOLOGY (2021)
STAT6 Pathway Is Critical for the Induction and Function of Regulatory T Cells Induced by Mucosal B Cells
Kuan-Hua Chu et al.
FRONTIERS IN IMMUNOLOGY (2021)
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies
Marc Emmenegger et al.
EMBO MOLECULAR MEDICINE (2021)
A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells
Lawrence P. Andrews et al.
IMMUNITY (2021)
Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease
Shengnan Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
LAG-3 and GAL-3 in Endometrial Carcinoma: Emerging Candidates for Immunotherapy
Lisa A. Friedman et al.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY (2020)
Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding
Lawrence P. Andrews et al.
SCIENCE IMMUNOLOGY (2020)
Expression and clinical significance of LAG-3, FGL1, PD-L1 and CD8+T cells in hepatocellular carcinoma using multiplex quantitative analysis
Mengzhou Guo et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2020)
Inhibitory receptor agonists: the future of autoimmune disease therapeutics?
Stephanie Grebinoski et al.
CURRENT OPINION IN IMMUNOLOGY (2020)
Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation
Takeo K. Maeda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non-Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis
Ila Datar et al.
CLINICAL CANCER RESEARCH (2019)
CD4+ T cell exhaustion revealed by high PD-1 and LAG-3 expression and the loss of helper T cell function in chronic hepatitis B
Yuejiao Dong et al.
BMC IMMUNOLOGY (2019)
Elevated LAG-3 on CD4+ T cells negatively correlates with neutralizing antibody response during HCV infection
Jian Zhang et al.
IMMUNOLOGY LETTERS (2019)
pDC depletion induced by CD317 blockade drives the antitumor immune response in head and neck squamous cell carcinoma
Lei-Lei Yang et al.
ORAL ONCOLOGY (2019)
Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3
Jun Wang et al.
CELL (2019)
LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells
Andreia C. Lino et al.
IMMUNITY (2018)
Regional expression of genes mediating trans-synaptic alpha-synuclein transfer predicts regional atrophy in Parkinson disease
Benjamin Freeze et al.
NEUROIMAGE-CLINICAL (2018)
Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted
Jeremy S. Tilstra et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
Lymphocyte activation gene 3 (Lag3) expression is increased in prion infections but does not modify disease progression
Yingjun Liu et al.
SCIENTIFIC REPORTS (2018)
Treg Fragility: A Prerequisite for Effective Antitumor Immunity?
Abigail E. Overacre-Delgoffe et al.
CANCER IMMUNOLOGY RESEARCH (2018)
Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067): 4-year outcomes of a multicentre, randomised, phase 3 trial
Frank Stephen Hodi et al.
LANCET ONCOLOGY (2018)
LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII
Takumi Maruhashi et al.
NATURE IMMUNOLOGY (2018)
Beyond Type 1 Regulatory T Cells: Co-expression of LAG3 and CD49b in IL-10-Producing T Cell Lineages
Weishan Huang et al.
FRONTIERS IN IMMUNOLOGY (2018)
Function and regulation of LAG3 on CD4+CD25- T cells in non-small cell lung cancer
Qin-Yun Ma et al.
EXPERIMENTAL CELL RESEARCH (2017)
LAG3 (CD223) as a cancer immunotherapy target
Lawrence P. Andrews et al.
IMMUNOLOGICAL REVIEWS (2017)
Interleukin-10-producing LAG3+ regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis
Shinichiro Nakachi et al.
ARTHRITIS RESEARCH & THERAPY (2017)
LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes
Qianxia Zhang et al.
SCIENCE IMMUNOLOGY (2017)
An IL-27/Lag3 axis enhances Foxp3(+) regulatory T cell-suppressive function and therapeutic efficacy
J-s Do et al.
MUCOSAL IMMUNOLOGY (2016)
Lymphocyte-activation gene 3+ (LAG3+) forkhead box protein 3- (FOXP3-) regulatory T cells induced by B cells alleviates joint inflammation in collagen-induced arthritis
Szu-Ying Chen et al.
JOURNAL OF AUTOIMMUNITY (2016)
Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production
Kaoru Morita et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3
Xiaobo Mao et al.
SCIENCE (2016)
LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma
Wei-Wei Deng et al.
ONCOIMMUNOLOGY (2016)
Lymphocyte activation gene 3 negatively regulates the function of intrahepatic hepatitis C virus-specific CD8+ T cells
Na Chen et al.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2015)
Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment
Jennifer A. Juno et al.
RETROVIROLOGY (2015)
TGF-β3-expressing CD4+CD25-LAG3+ regulatory T cells control humoral immune responses
Tomohisa Okamura et al.
NATURE COMMUNICATIONS (2015)
LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model
Ruea-Yea Huang et al.
ONCOTARGET (2015)
Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells
Theodore Kouo et al.
CANCER IMMUNOLOGY RESEARCH (2015)
LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses
Feng Xu et al.
CANCER RESEARCH (2014)
Lymphocyte activation gene-3 (LAG-3, CD223) in plasmacytoid dendritic cells (pDCs): a molecular target for the restoration of active antitumor immunity
Chiara Castelli et al.
ONCOIMMUNOLOGY (2014)
Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
Nicola Gagliani et al.
NATURE MEDICINE (2013)
Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape
Seng-Ryong Woo et al.
CANCER RESEARCH (2012)
PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice
Taku Okazaki et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Cutting Edge: Accelerated Autoimmune Diabetes in the Absence of LAG-3
Maria Bettini et al.
JOURNAL OF IMMUNOLOGY (2011)
High Expression of Lymphocyte-Activation Gene 3 (LAG3) in Chronic Lymphocytic Leukemia Cells Is Associated with Unmutated lmmunoglobulin Variable Heavy Chain Region (IGHV) Gene and Reduced Treatment-Free Survival
Jana Kotaskova et al.
JOURNAL OF MOLECULAR DIAGNOSTICS (2010)
Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer
Junko Matsuzaki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Functionally Distinct LAG-3 and PD-1 Subsets on Activated and Chronically Stimulated CD8 T Cells
Joseph F. Grosso et al.
JOURNAL OF IMMUNOLOGY (2009)
LAG-3 Regulates Plasmacytoid Dendritic Cell Homeostasis
Creg J. Workman et al.
JOURNAL OF IMMUNOLOGY (2009)
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
Shawn D. Blackburn et al.
NATURE IMMUNOLOGY (2009)
CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2
Tomohisa Okamura et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Molecular signature of CD8+ T cell exhaustion during chronic viral infection
E. John Wherry et al.
IMMUNITY (2007)
Metalloproteases regulate T-cell proliferation and effector function via LAG-3
Nianyu Li et al.
EMBO JOURNAL (2007)
Expression of lymphocyte activation gene 3 (LAG-3) on B cells is induced by T cells
M Kisielow et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2005)
Biochemical analysis of the regulatory T cell protein lymphocyte activation gene-3 (LAG-3; CD223)
NY Li et al.
JOURNAL OF IMMUNOLOGY (2004)
The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells
CJ Workman et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2003)
Cutting edge: Molecular analysis of the negative regulatory function of lymphocyte activation gene-3
CJ Workman et al.
JOURNAL OF IMMUNOLOGY (2002)