Chemical fast track to induced pluripotency

A fast protocol for chemical cellular reprogramming reveals a diapause-like state, endogenous retrovirus activation and barriers to cell-fate transitions on the way to pluripotency. The system offers insights into manipulation of cellular regeneration and rejuvenation, two processes with great therapeutic potential.

Automated summary

A rapid chemical protocol for cellular reprogramming uncovers a state similar to diapause, retrovirus activation, and obstacles in cell fate transitions towards pluripotency. The system provides valuable insights into manipulating cellular regeneration and rejuvenation, showing promising therapeutic potential.