Phytochemical constituents from rhizomes of Dryopteris crassirhizoma and their anti-inflammatory activity

Article Plant Sciences

Antimicrobial Acylphloroglucinol Meroterpenoids and Acylphloroglucinols from Dryopteris crassirhizoma

Ping Hai et al.

Summary: Novel meroterpenoids with unique structures were isolated from D. crassirhizoma, showing promising antifungal and antibacterial activities, indicating their potential as drug candidates.

PLANTA MEDICA (2023)

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Article Chemistry, Medicinal

New tocopherol and acylphloroglucinol derivatives from Dryopteris crassirhizoma and their antimicrobial activities

Ping Hai et al.

Summary: Nine new compounds, including six tocopherol derivatives and three acylphloroglucinol derivatives, have been isolated and characterized from a type of fern. These compounds have unique structures and exhibit significant antimicrobial activities against Candida albicans, plant pathogenic fungi, and bacteria.

FITOTERAPIA (2023)

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Article Biochemistry & Molecular Biology

Structure elucidation, biogenesis, and bioactivities of acylphloroglucinol-derived meroterpenoid enantiomers from Dryopteris crassirhizoma

Ping Hai et al.

Summary: Twenty-four racemic acylphloroglucinol meroterpenoids were isolated from Dryopteris crassirhizoma, including eighteen unusual structures and a major component filixic acid ABA. The dimeric acylphloroglucinol derivatives possess unprecedented skeletons of mixed acylphloroglucinol and sesquiterpene biosynthetic origin. The stereochemistries of six reported meroterpenoids were reassigned using two intriguing methods. Two of the isolated compounds (13 and 14) showed obvious inhibitory effects on inflammatory response, while another compound (25) exhibited antiviral efficacy against the influenza virus.

BIOORGANIC CHEMISTRY (2022)

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Article Chemistry, Applied

Three Novel Monoterpenoid Glycosides From Fruits Of Eleutherococcus Henryi

Xiao-Jun Li et al.

Summary: The phytochemical investigation of Eleutherococcus henryi fruits led to the discovery of three novel monoterpene glycosides, with compounds 1 and 3 showing inhibitory effects on NO production in LPS-stimulated BV2 microglia. Additionally, (-)-kobusin demonstrated potential anti-neuroinflammatory and anti-inflammatory activities by inhibiting NO production in BV2 and RAW264.7 cells.

NATURAL PRODUCT RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Phloroglucinol Derivatives from Dryopteris crassirhizoma as Potent Xanthine Oxidase Inhibitors

Heung Joo Yuk et al.

Summary: The rhizomes of Dryopteris crassirhizoma contain potent xanthine oxidase inhibitory compounds, with flavaspidic acid AP showing the strongest inhibitory activity. These inhibitors exhibit reversible and noncompetitive inhibition towards xanthine oxidase.

MOLECULES (2021)

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Review Chemistry, Applied