4.4 Article

Phytochemical constituents from rhizomes of Dryopteris crassirhizoma and their anti-inflammatory activity

Journal

NATURAL PRODUCT RESEARCH
Volume -, Issue -, Pages -

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2023.2256446

Keywords

Dryopteris crassirhizoma; dryopteridaceae; fatty ester amides; drycrassirhizomamide A; drycrassirhizomamide B; anti-inflammatory

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Phytochemical investigation of Dryopteris crassirhizoma led to the discovery of two new compounds and identification of four known compounds. The compounds exhibited inhibitory effects on inflammation, demonstrating their potential anti-inflammatory activity.
The phytochemical investigation on the rhizomes of Dryopteris crassirhizoma (Dryopteridaceae) resulted in the discovery of one novel compound, drycrassirhizomamide A (1), and one new natural product, drycrassirhizomamide B (2), as well as four known isolates, (S)-(-)-N-benzoylphenylalaninol (3), blumenol A (4), 8-C-glucosylnoreugenin (5), and dryopteroside (6). Their chemical structures were identified by NMR and mass spectroscopy. Compounds 1-2 were determined to be 1,19-diethyl 10-oxo-2,9,11,18-tetraazanonadecanedioate and C,C'-diethyl N,N'-1,6-hexanediylbis[carbamate]. The anti-inflammatory activities of these compounds were evaluated with LPS-stimulated RAW264.7 macrophage and BV2 microglia. The results showed that compounds 1-3 and 6 have inhibitory effects of NO production with IC50 values of 13.41, 30.36, 25.51, and 11.35 mu M in LPS-stimulated RAW264.7 cells. Also, compounds 1 and 4-6 have abilities to inhibit NO production with the IC50 values of 40.11, 30.94, 15.76, and 16.79 mu M in BV2 cells, which demonstrated that they may possess the potential anti-inflammatory activity. [GRAPHICS.]

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