Journal
NATURAL PRODUCT COMMUNICATIONS
Volume 18, Issue 7, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1934578X221128097
Keywords
Solanaceae; Datura metel leaves; natural products; sesquiterpenoids; anti-inflammatory activity
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A new sesquiterpenoid compound, dmetelin J (1), was isolated from the leaves of Datura metel L., along with four known compounds: apocynol A (2), blumenol B (3), megastigmane (4), and ( + )-dehydrovomifoliol (5). The structure of dmetelin J (1) was determined using spectroscopic techniques, including 1D and 2D NMR spectroscopy and HRESIMS. Compounds 2, 3, and 5 were isolated from the Solanaceae family for the first time. Anti-inflammatory activity evaluation was performed on all isolated compounds.
In the course of chemical investigations of Datura metel L., a new sesquiterpenoid, dmetelin J (1) was isolated from the leaves, along with the 4 known compounds apocynol A (2), blumenol B (3), megastigmane (4), and ( + )-dehydrovomifoliol (5). Structure elucidation was performed by spectroscopic techniques, including 1- and 2-dimensional NMR spectroscopy and HRESIMS. Compounds 2, 3, and 5 were isolated from the Solanaceae for the first time. All isolated compounds were subjected to anti-inflammatory activity evaluation.
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