Journal
NANOMEDICINE
Volume 18, Issue 17, Pages 1109-1134Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2023-0005
Keywords
carbon dots; cell differentiation; cell imaging; fate control; stem cells
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This review comprehensively summarizes the research on carbon dots in terms of synthesis methods, optical properties, and biotoxicity. It focuses on the application of carbon dots in stem cell imaging and differentiation, aiming to stimulate the design of future related carbon dots.
Carbon dots (CDs) have been widely used in bioimaging, biosensing and biotherapy because of their good biocompatibility, optical properties and stability. In this review, we comprehensively summarize the research on CDs in terms of synthesis methods, optical properties and biotoxicity. We describe and envisage the directions for CDs application in stem cell imaging and differentiation, with the aim of stimulating the design of future related CDs. We used 'carbon dots', 'stem cells', 'cell imaging', 'cell differentiation' and 'fate control' as keywords to search for important articles. The Web of Science database was used to extract vital information from a total of 357 papers, 126 review articles and 231 article proceedings within 12 years (2011-2022).
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