Total Synthesis of Nicrophorusamide A and Structural Disproof of the Proposed Noursamycin A

Total synthesis of the proposed noursamycin A has been accomplished, which disproves the original structural assignments. The synthetic strategy described herein has also been employed in the first total synthesis of nicrophorusamide A, a cyclopeptide that is structurally related to noursamycin A.

Automated summary

The total synthesis of noursamycin A has been achieved, which proves that the original structural assignments were incorrect. The synthetic strategy described in this paper has also been utilized for the first total synthesis of nicrophorusamide A, a cyclopeptide that shares structural similarities with noursamycin A.