Journal
MOLECULES
Volume 28, Issue 18, Pages -Publisher
MDPI
DOI: 10.3390/molecules28186619
Keywords
multi-residue; detection; glucocorticoids; electrochemical immunosensor; receptor
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A novel nano-Au/fluticasone propionate electrochemical immunosensor was fabricated based on an indirect competitive method. The immunosensor showed attractive electrochemical performance with a wide linear range and low detection limit, enabling rapid detection of multiple glucocorticoids.
Based on an indirect competitive method, a novel nano-Au/fluticasone propionate electrochemical immunosensor was successfully fabricated by combining the nanoscale effect, superior conductivity of nano-Au, stable Au-S chemical bond as well as strong interaction between glucocorticoid and the receptor, which was used to simultaneously detect eight kinds of glucocorticoids. The modified immunosensors' electrochemical properties were explored by means of a cyclic voltammetry (CV) method and electrochemical impedance spectroscopy (EIS) measurements. Two factors (glucocorticoid receptor concentration, incubation time) were studied in order to obtain the optimal results. The immunosensor presents attractive electrochemical performance with a wide linear range (between 0.1 and 1500 ng center dot mL(-1)) and low detection limit (between 0.057 and 0.357 ng center dot mL(-1)), realizing the rapid multi-residue detection of a large class of glucocorticoids. Two glucocorticoids (hydrocortisone, triamcinolone) were detected in actual skincare samples, which obtained satisfactory detection results.
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