An In Vivo Assessment of the Effect of Hexane Extract from Endlicheria paniculata Branches and Its Main Compound, Methyldehydrodieugenol B, on Murine Sponge-Induced Inflammation

The present study aims to explore the anti-inflammatory potential activity of the hexane extract from branches (HEB) of Endlicheria paniculata (Lauraceae) and its main compound, methyldehydrodieugenol B, in the inflammatory response induced by a murine implant sponge model. HPLC-ESI/MS analysis of HEB led to the identification of six chemically related neolignans, with methyldehydrodieugenol B as the main compound. An in silico analysis of the pharmacokinetic parameters of the identified compounds suggested moderate solubility but good absorption and biodistribution in vivo. Thus, the treatment of mice with HEB using in vivo assays indicated that HEB promoted pro-inflammatory, antiangiogenic, and antifibrogenic effects, whereas treatment with methyldehydrodieugenol B caused anti-inflammatory, antifibrogenic, and antiangiogenic effects. The obtained results shown the therapeutic potential of HEB and methyldehydrodieugenol B in the treatment of pathologies associated with inflammation and angiogenesis, including chronic wounds.

Automated summary

The study investigates the anti-inflammatory potential of the hexane extract from Endlicheria paniculata branches (HEB) and its main compound, methyldehydrodieugenol B, in a murine implant sponge model. HPLC-ESI/MS analysis identified six chemically related neolignans in HEB, with methyldehydrodieugenol B as the main compound. In silico analysis of the identified compounds suggested good absorption and biodistribution in vivo. The results showed therapeutic potential of HEB and methyldehydrodieugenol B in treating inflammation and angiogenesis-related pathologies, including chronic wounds.