4.6 Article

Ophthalmic Intervention of Naringenin Decreases Vascular Endothelial Growth Factor by Counteracting Oxidative Stress and Cellular Damage in In Vivo Zebrafish

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Nimbin analog N2 alleviates high testosterone induced oxidative stress in CHO cells and alters the expression of Tox3 and Dennd1a signal transduction pathway involved in the PCOS zebrafish

Gokul Sudhakaran et al.

Summary: This study found that N2 has anti-androgenic properties and can alleviate oxidative stress and apoptosis in PCOS models. N2 also improves GSI and SOD enzyme expression in zebrafish ovaries, and normalizes follicular maturation arrest. The expression of hormone-related genes Tox3 and Denndla is regulated by N2.

PHYTOTHERAPY RESEARCH (2023)

Review Marine & Freshwater Biology

State-of-the-art review on the ecotoxicology, health hazards, and economic loss of the impact of microcystins and their ultrastructural cellular changes

Maruthanayagam Veerabadhran et al.

Summary: Cyanobacteria are widely distributed in freshwater and marine environments worldwide, and their toxins have harmful effects on health. Microcystins, the toxic metabolites produced by cyanobacteria, cause significant damage to cells, influencing the morphological, biochemical, physiological, and genetic status of the host. Microcystins also have detrimental effects on animals, plants, agriculture, public health, ecotoxicology, and economic consequences. Comprehensive cellular assessment could provide opportunities for therapeutic implications.

AQUATIC TOXICOLOGY (2023)

Article Pharmacology & Pharmacy

Hepatoprotective effect of dihydroxy piperlongumine in high cholesterol-induced non-alcoholic fatty liver disease zebrafish via antioxidant activity

B. Haridevamuthu et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are common liver diseases caused by a western diet high in fats, which induce inflammation and impair hepatocyte function. Currently, there is a lack of pharmacological drugs for treating NAFLD/NASH. However, long pepper contains a bioactive compound called Piperlongumine (PL) that has potential antioxidant properties. In this study, demethylated dihydroxy piperlongumine (DHPL) was shown to have high antioxidant activity and was effective in reducing lipid accumulation and gene expression associated with NAFLD in a zebrafish model. DHPL may have therapeutic potential for halting the progression of NAFLD.

EUROPEAN JOURNAL OF PHARMACOLOGY (2023)

Article Environmental Sciences

Syringol, a wildfire residual methoxyphenol causes cytotoxicity and teratogenicity in zebrafish model

P. Snega Priya et al.

Summary: This study evaluates the cytotoxic and teratogenic effects of methoxy phenols (MPs) generated by wildfire lignin on human embryonic kidney (HEK-293) cells and zebrafish embryos. The results indicate that MPs, particularly syringol, have toxic effects on both cells and embryos, including cell death, developmental abnormalities, and increased oxidative stress response. Therefore, syringol has the potential to pose serious health hazards in various living systems.

SCIENCE OF THE TOTAL ENVIRONMENT (2023)

Article Immunology

Luteolin, a promising quorum quencher mitigates virulence factors production in Pseudomonas aeruginosa- In vitro and In vivoapproach

S. P. Ramya Ranjan Nayak et al.

Summary: The study demonstrates the protective effect of luteolin against Pseudomonas aeruginosa (PA)-mediated inflammation using a zebrafish model. Luteolin not only protects zebrafish from PA infection and enhances their survival rate, but also reduces PA-mediated oxidative stress, lipid peroxidation, and apoptosis in zebrafish larvae. Moreover, luteolin improves the behavior and gut inflammation in PA-infected zebrafish and alters the expression of inflammatory and antioxidant markers. Therefore, luteolin could be a potential therapeutic drug to control multi-drug resistant PA.

MICROBIAL PATHOGENESIS (2023)

Article Multidisciplinary Sciences

Neuroprotective and antioxidant capability of RW20 peptide from histone acetyltransferases caused by oxidative stress-induced neurotoxicity in in vivo zebrafish larval model

Nagaram Prabha et al.

Summary: This study evaluated the neuroprotective and antioxidant ability of a short peptide, RW20, and demonstrated its prominent antioxidant activity. Therefore, RW20 may be developed as a potent therapeutic agent against oxidative stress-induced neurodegenerative diseases.

JOURNAL OF KING SAUD UNIVERSITY SCIENCE (2022)

Article Neurosciences

Amelioration of acrylamide induced neurotoxicity by benzo[b]thiophene analogs via glutathione redox dynamics in zebrafish larvae

B. Haridevamuthu et al.

Summary: This study demonstrates the therapeutic potential of compounds BP and EP in oxidative stress-associated neurological disorders. The experiment shows that these compounds can restore glutathione redox dynamics, reduce oxidative stress and neuroinflammation, and partially restore the normal function of motor neurons.

BRAIN RESEARCH (2022)

Article Biochemistry & Molecular Biology

Daidzein normalized gentamicin-induced nephrotoxicity and associated pro-inflammatory cytokines in MDCK and zebrafish: Possible mechanism of nephroprotection

Ajay Guru et al.

Summary: This study investigated the therapeutic activity of daidzein against gentamicin-induced nephrotoxicity in vitro and in vivo. Daidzein was found to protect MDCK cells from inflammation and apoptosis caused by gentamicin. In the zebrafish model, daidzein treatment showed a strong anti-inflammatory effect and normalized histopathological alterations caused by gentamicin. Daidzein also downregulated the expression of pro-inflammatory cytokines in kidney inflammation. These results suggest that daidzein could potentially prevent nephrotoxic conditions through inhibiting pro-inflammatory cytokines and its antioxidant property.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY (2022)

Article Immunology

Withaferin A targets the membrane of Pseudomonas aeruginosa and mitigates the inflammation in zebrafish larvae; an in vitro and in vivo approach

Raghul Murugan et al.

Summary: Infections caused by multidrug-resistant Pseudomonas aeruginosa are common in patients with cystic fibrosis. Withaferin A extracted from ashwagandha has shown strong antibacterial activity against P. aeruginosa by damaging the cell membrane. Treatment with Withaferin A reduced oxidative stress and inflammatory response in a zebrafish larvae model infected with P. aeruginosa.

MICROBIAL PATHOGENESIS (2022)

Article Pharmacology & Pharmacy

Deacetylated nimbin analog N2 fortifies alloxan-induced pancreatic β-cell damage in insulin-resistant zebrafish larvae by upregulating phosphoenolpyruvate carboxykinase (PEPCK) and insulin levels

Gokul Sudhakaran et al.

Summary: This study evaluated the protective effect of N2 against alloxan-induced oxidative damage and beta-cell dysfunction in zebrafish larvae. N2 showed significant protection by reducing oxidative stress on beta-cells and improving glucose uptake, leading to lower blood glucose levels.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2022)

Article Fisheries

Intracellular ROS scavenging and antioxidant regulation of WL15 from cysteine and glycine-rich protein 2 demonstrated in zebrafish in vivo model

Ajay Guru et al.

Summary: The study showed that WL15 peptide possesses strong antioxidant properties, which were validated through in vitro and in vivo experiments. Results from zebrafish experiments demonstrated that WL15 peptide can reduce intracellular ROS levels and inhibit apoptotic responses induced by H2O2.

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

TL15 of Arthrospira platensis sulfite reductase scavenges free radicals demonstrated in oxidant induced larval zebrafish (Danio rerio) model

Purabi Sarkar et al.

Summary: The study identified the antioxidant role of sulfite reductase derived from Arthrospira platensis through the short peptide TL15, which showed strong antioxidant activity without toxicity in human leukocytes. In zebrafish larvae, TL15 peptide reduced H2O2-induced ROS levels and enhanced antioxidant enzyme activity. Overall, TL15 acts as a potential antioxidant with dose-specific properties, making it promising for biopharmaceutical applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Medicine, Research & Experimental

Development of a zebrafish screening model for diabetic retinopathy induced by hyperglycemia: Reproducibility verification in animal model

Yujin Lee et al.

Summary: This study successfully established a zebrafish screening model for diabetic retinopathy and evaluated the efficacy of aflibercept. Aflibercept significantly reduced retinal vessel diameter at glucose concentrations of 130-160 mM, with 100 μg/mL being confirmed as an effective dose for the zebrafish diabetic retinopathy model.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Medicine, Research & Experimental

Oxidative stress induced antioxidant and neurotoxicity demonstrated in vivo zebrafish embryo or larval model and their normalization due to morin showing therapeutic implications

Praveen Kumar Issac et al.

Summary: The study demonstrated that morin provides neuroprotection in zebrafish larvae by restoring antioxidant enzyme activity and reducing lipid peroxidation to alleviate oxidative stress-induced cellular apoptosis and ROS levels. This mechanism enhances cellular antioxidant defense and could be a novel strategy for combating oxidative stress.

LIFE SCIENCES (2021)

Review Endocrinology & Metabolism

The Role of Lipoxidation in the Pathogenesis of Diabetic Retinopathy

Josy Augustine et al.

Summary: Lipid peroxidation can lead to the production of reactive aldehyde species, forming ALEs that play a role in diabetic retinopathy complications. Further research and potential therapeutic approaches are being explored to prevent irreversible damage from occurring.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Association of Agriculture Occupational Exposure With Diabetes and Cardiovascular Risk Factors in South Indian Villages: REDSI Study

Ganesan Velmurugan et al.

Summary: The study revealed a high prevalence of diabetes in rural South India, particularly among the farming community. Logistic regression analysis showed a strong association between agrochemical exposure and diabetes prevalence among rural farmers. This survey emphasizes the importance of understanding the etiology of diabetes and other cardiovascular risk factors in rural communities.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Review Cell Biology

Which Hyperglycemic Model of Zebrafish (Danio rerio) Suites My Type 2 Diabetes Mellitus Research? A Scoring System for Available Methods

Aria Salehpour et al.

Summary: Despite extensive studies on type 2 diabetes mellitus (T2DM), there is currently no definitive cure, drug, or prevention available. Proper study models of T2DM are necessary for developing new therapeutics, and different methods of inducing diabetes in animal models have been suggested. While the rat model is commonly used, zebrafish models of diabetes are becoming more popular in research. By comparing different methods and evaluating a scoring system, researchers can select the most suitable T2DM zebrafish model for their research theme, with the glo1(-/-) knockout model of hyperglycemia receiving the highest score. Additionally, eight commonly proposed diabetic induction methods are suggested for researchers to confirm their subsequent proposed models.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Insulin signaling pathway assessment by enhancing antioxidant activity due to morin using in vitro rat skeletal muscle L6 myotubes cells

Praveen Kumar Issac et al.

Summary: Morin acts as an antioxidant by reducing ROS levels and demonstrating insulin mimetic activity, reversing insulin resistance associated with oxidative stress.

MOLECULAR BIOLOGY REPORTS (2021)

Review Pharmacology & Pharmacy

Naringin and naringenin as anticancer agents and adjuvants in cancer combination therapy: Efficacy and molecular mechanisms of action, a comprehensive narrative review

Zahra Memariani et al.

Summary: Cancer rates are increasing in many low- and middle-income countries due to various factors, including lifestyle changes and societal problems. Different treatment approaches like chemotherapy, surgery, and radiation therapy are used, but can have various short- and long-term side effects. Recent studies show that compounds like naringin and naringenin from citrus fruits have anti-cancer properties through different signaling pathways, and when combined with current anti-cancer agents, can show synergistic effects and help overcome multidrug resistance in cancer treatment.

PHARMACOLOGICAL RESEARCH (2021)

Review Chemistry, Medicinal

The Therapeutic Potential of Naringenin: A Review of Clinical Trials

Bahare Salehi et al.

PHARMACEUTICALS (2019)

Article Chemistry, Multidisciplinary

Cocrystals and a Salt of the Bioactive Flavonoid: Naringenin

U. B. Rao Khandavilli et al.

CRYSTAL GROWTH & DESIGN (2018)

Article Nutrition & Dietetics

Effects of a high-fat diet on superoxide anion generation and membrane fluidity in liver mitochondria in rats

M. Togo et al.

JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION (2018)

Article Chemistry, Applied

Antioxidant and anti-inflammatory activities of phenolic compounds isolated from Melipona beecheii honey

Jorge Carlos Ruiz-Ruiz et al.

FOOD AND AGRICULTURAL IMMUNOLOGY (2017)

Review Biochemistry & Molecular Biology

Zebrafish as a Model for the Study of Microvascular Complications of Diabetes and Their Mechanisms

Karl Heckler et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Environmental Sciences

Nicotine Component of Cigarette Smoke Extract (CSE) Decreases the Cytotoxicity of CSE in BEAS-2B Cells Stably Expressing Human Cytochrome P450 2A13

Minghui Ji et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2017)

Article Pharmacology & Pharmacy

Metformin as a Rare Cause of Drug-Induced Liver Injury, a Case Report and Literature Review

Lin Zheng

AMERICAN JOURNAL OF THERAPEUTICS (2016)

Review Endocrinology & Metabolism

Treatment of diabetic retinopathy: Recent advances and unresolved challenges

Michael W. Stewart

WORLD JOURNAL OF DIABETES (2016)

Review Cell Biology

Vascular Complications of Diabetes: Mechanisms of Injury and Protective Factors

Christian Rask-Madsen et al.

CELL METABOLISM (2013)

Review Ophthalmology

Diabetic Retinopathy and Inflammation: Novel Therapeutic Targets

Sampathkumar Rangasamy et al.

MIDDLE EAST AFRICAN JOURNAL OF OPHTHALMOLOGY (2012)

Article Ophthalmology

The Significance of Vascular and Neural Apoptosis to the Pathology of Diabetic Retinopathy

Alistair J. Barber et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2011)

Review Pharmacology & Pharmacy

Vascular endothelial growth factor and diabetic retinopathy: Role of oxidative stress

RB Caldwell et al.

CURRENT DRUG TARGETS (2005)