Total Syntheses of Colletopeptide A and Colletotrichamide A

The first total syntheses of cyclic depsipeptides colletopeptide A and colletotrichamide A, have been accomplished. The key advanced intermediate, a cyclic tridepsipeptide derivative, was constructed using a sequence of transformations that features asymmetric Brown crotylation, cross metathesis, Yamaguchi esterification, ozonolysis, and macrolactamization. A late-stage incorporation of the mannose fragment completed the synthesis of colletotrichamide A, and the desilylation of the common intermediate gave rise to colletopeptide A, which led to unambiguous confirmation of the absolute stereochemistry of the aforementioned natural products.

Automated summary

The first total syntheses of cyclic depsipeptides colletopeptide A and colletotrichamide A have been achieved through a series of transformations. By constructing a cyclic tridepsipeptide derivative as a key intermediate, followed by late-stage incorporation of the mannose fragment, the synthesis of colletotrichamide A and desilylation of the common intermediate led to the confirmation of the absolute stereochemistry of the natural products.