Evaluating the Aphrodisiac Potential of Mirabilis jalapa L. Root Extract: Phytochemical Profiling and In Silico, In Vitro, and In Vivo Assessments in Normal Male Rats

Article Nutrition & Dietetics

A Proprietary Herbal Blend Containing Extracts of Punica granatum Fruit Rind and Theobroma cocoa Seeds Increases Serum Testosterone Level in Healthy Young Males: A Randomized, Double-Blind Placebo-Controlled Study

Poorna Gopal Azad Sreeramaneni et al.

Summary: LN18178 is a safe and tolerable herbal blend that can increase testosterone levels, improve muscle strength, and increase mid-upper arm circumference in young, healthy males.

JOURNAL OF DIETARY SUPPLEMENTS (2023)

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Article Plant Sciences

Effects of Mirabilis jalapa L. root extract and sildenafil on paroxetine- induced sexual dysfunction in male rats and characterization of its phytoconstituents by UPLC-MS

Asad Ur Rahman et al.

Summary: The effects of Mirabilis jalapa L. root extract on paroxetine-induced sexual dysfunction in male rats were investigated. The results showed that treatment with 300 mg/kg M. jalapa extract significantly increased sexual activity and frequencies of mount, intromission, and ejaculation in male rats. The analysis also identified several biologically active constituents in M. jalapa root extract. This study confirmed the strong aphrodisiac effect of M. jalapa root extract on paroxetine-induced sexually depressed male rats.

SOUTH AFRICAN JOURNAL OF BOTANY (2023)

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Article Biochemistry & Molecular Biology

Zinc improves sexual performance and erectile function by preventing penile oxidative injury and upregulating circulating testosterone in lead-exposed rats

Elizabeth Enohnyket Besong et al.

Summary: This study evaluated the effect of lead exposure on male sexual and erectile function, and verified the therapeutic effect of zinc. The results showed that zinc co-administration significantly improved penile weights, sexual behavior parameters, motivation to mate, and penile reflex/erection in lead-exposed rats. Zinc also attenuated lead-induced suppression of nitric oxide (NO), cyclic guanosine monophosphate (cGMP), dopamine, luteinizing hormone, follicle-stimulating hormone, and testosterone. Moreover, zinc alleviated lead-induced oxidative stress and upregulated testosterone via Nrf2-mediated signaling.

REDOX REPORT (2023)

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Article Plant Sciences

Effects of Spirulina maxima on a Model of Sexual Dysfunction in Streptozotocin-Induced Diabetic Male Rats

Eduardo Osel Olvera-Roldan et al.

Summary: The study aimed to evaluate the effects of Spirulina maxima on diabetic male rats in terms of body weight, glycemia, sexual behavior, sperm quality, testosterone levels, sex organ weights, and the activity of antioxidant enzymes. The results showed that Spirulina maxima significantly improved sexual behavior and sperm quality in diabetic animals.

PLANTS-BASEL (2023)

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Article Psychology, Biological

Ejaculation latency determines susceptibility to stress in the male rat

Carolina Sotelo-Tapia et al.

Summary: Stress has varying effects on sexual behavior, including enhancing execution or completely eliminating sexual interaction. This study investigates the relationship between sexual execution and susceptibility to stress. The results show that rats more susceptible to stress have longer ejaculation latency, even before stress is applied.

BEHAVIOURAL PROCESSES (2023)

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Article

Levels of elements in selected food substances that support usage in the management and treatment of erectile dysfunction

Michael Lartey et al.

Nutrition and Health (2023)

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Article Biochemistry & Molecular Biology

Comparative Antihyperglycemic and Antihyperlipidemic Effects of Lawsone Methyl Ether and Lawsone in Nicotinamide-Streptozotocin-Induced Diabetic Rats

Muhammad Khan et al.

Summary: The combination of LME and lawsone from Impatiens balsamina effectively reduces blood glucose, insulin, and lipid levels in diabetic rats, without causing toxicity.

METABOLITES (2023)

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Article Biochemistry & Molecular Biology

Aphrodisiac Performance of Bioactive Compounds from Mimosa pudica Linn.: In Silico Molecular Docking and Dynamics Simulation Approach

Chandrasekar Palanichamy et al.

Summary: This study aimed to predict highly effective molecules from Mimosa pudica Linn. for treating male erectile dysfunction through molecular docking and dynamics simulation. Four bioactive molecules showed stronger binding affinities with the target enzyme compared to the standard inhibitor, suggesting their potential as potent PDE5 inhibitors for the treatment of ED.

MOLECULES (2022)

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Article Medicine, General & Internal

Ameliorative Sexual Behavior and Phosphodiesterase-5 Inhibitory Effects of Spondias mangifera Fruit Extract in Rodents: In Silico, In Vitro, and In Vivo Study

Mohammad Khalid et al.

Summary: This study evaluated the aphrodisiac activity of ethanolic extracts from Spondias mangifera fruit. In vitro molecular docking and simulation studies demonstrated the inhibition of phosphodiesterase-5 (PDE-5) by the extracts. In vivo analysis of sexual behavior and biochemical parameters confirmed the positive effects of the extracts on sexual performance and the levels of PDE-5, nitric oxide, and testosterone. The results suggest that the ethanolic extract of S. mangifera could be a valuable alternative aphrodisiac for erectile dysfunction.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Pharmacology & Pharmacy

Scaffold Repurposing Reveals New Nanomolar Phosphodiesterase Type 5 (PDE5) Inhibitors Based on Pyridopyrazinone Scaffold: Investigation of In Vitro and In Silico Properties

Kamelia M. Amin et al.

Summary: This study utilized a multi-step in silico approach, in vitro biological evaluation, and SAR study to identify novel compounds with anticancer potential and PDE5 inhibitory activity. Compound 11b exhibited the highest potency and molecular dynamic simulation provided insights into its inhibitory mechanism.

PHARMACEUTICS (2022)

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Article Tropical Medicine

β-Islet cell regeneration potential of Mirabilis jalapa in hyperglycemic rats

Masud Eneji Sadiq et al.

Summary: Mirabilis jalapa extracts have the potential to restore glucose homeostasis, lower blood glucose and lipid levels, increase antioxidant enzyme activity, and increase cell population in the islets of hyperglycemic rats.

ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE (2022)

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Review Pharmacology & Pharmacy