Journal
MOLECULES
Volume 28, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/molecules28155685
Keywords
Friedel-Crafts reaction; bis(indolyl)methanes; hydrogen-bond; acylsilanes
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A novel double Friedel-Crafts reaction of acylsilanes in water is reported, which allows for the synthesis of bis(indolyl)methane derivatives with 1-hydroxy or 1-silyl substituents in moderate to high yield. The selectivity of the reaction is regulated by the hydrogen bonds in the 5-hydroxyindole, leading to the synthesis of 1-hydroxy-bis(indolyl)methane derivatives.
A novel double Friedel-Crafts reaction of acylsilanes in water is described. This strategy enables synthesis of bis(indolyl)methane derivatives with 1-hydroxy or 1-silyl substituents in moderate to high yield. Compared to the 1-silyl-bis(indolyl)methane derivatives from indole substrate, 1-hydroxy-bis(indolyl)methane derivatives were synthesized from the 5-hydroxyindole, and the hydrogen bonds in the 5-hydroxyindole play a crucial role in regulating the reaction selectivity.
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