4.6 Article

Macrophage Activity under Hyperglycemia: A Study of the Effect of Resveratrol and 3H-1,2-Dithiole-3-thione on Potential Polarization

Related references

Note: Only part of the references are listed.
Article Cell Biology

3H-1,2-dithiole-3-thione suppresses LPS-induced proinflammatory responses in macrophages: potential involvement of antioxidant induction, NF-kappa B, and Nrf2

Hong Zhu et al.

Summary: The present study demonstrated that D3T acted as a potent suppressor of LPS-induced proinflammatory responses in macrophages. Antioxidant induction, NF-kappa B suppression, and Nrf2 activation appeared to contribute to the anti-proinflammatory activity of D3T in macrophages.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2022)

Review Biochemistry & Molecular Biology

Oxidative Stress and NRF2/KEAP1/ARE Pathway in Diabetic Kidney Disease (DKD): New Perspectives

Daniela Maria Tanase et al.

Summary: Diabetes mellitus is a debilitating chronic disease with increasing prevalence worldwide. Diabetic Kidney Disease is a major complication of diabetes, caused by mechanisms such as hyperglycemia, inflammation, and oxidative stress. NRF2-inducing strategies show potential in the treatment of Diabetic Kidney Disease, but limitations such as lack of large-scale clinical trials hinder their clinical use.

BIOMOLECULES (2022)

Review Biochemistry & Molecular Biology

Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy

Jie Pan et al.

Summary: Inflammation is a common basis for various diseases, and accurately regulating inflammatory homeostasis and understanding the role of protein phosphatases are crucial for developing drugs targeting inflammation-related diseases.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Article Multidisciplinary Sciences

Comparing the protective effects of resveratrol, curcumin and sulforaphane against LPS/IFN-gamma-mediated inflammation in doxorubicin-treated macrophages

Haidy A. Saleh et al.

Summary: The study suggests that DOX alone does not stimulate inflammatory response in RAW 264.7 macrophages, but in combination with LPS/IFN-gamma it significantly increases the expression of inflammatory markers, while SFN exhibits a potent inhibitory effect on inflammation, potentially serving as a treatment for DOX-associated inflammation.

SCIENTIFIC REPORTS (2021)

Review Immunology

Tissue Homeostasis and Inflammation

Matthew L. Meizlish et al.

Summary: The article discusses the importance of tissue organization, homeostasis, and inflammation, providing formal definitions and showing how they interact. Inflammation is seen as a response to deviations from homeostasis, and the hierarchical structure of homeostatic and inflammatory circuits affects the development of inflammatory diseases.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 39 (2021)

Article Chemistry, Multidisciplinary

Involvement of Antioxidant Defenses and NF-κB/ERK Signaling in Anti-Inflammatory Effects of Pterostilbene, a Natural Analogue of Resveratrol

Thanasekaran Jayakumar et al.

Summary: Pterostilbene (PTE), a natural stilbenoid found in grapes and berries, exhibits anti-inflammatory properties by attenuating NF-kappa B/ERK signaling pathways and enhancing antioxidant defense mechanisms. It significantly reduces NO production and expression of inflammatory factors, while inhibiting ERK activation and blocking phosphorylation and nuclear translocation of p65NF-kappa B.

APPLIED SCIENCES-BASEL (2021)

Article Biochemistry & Molecular Biology

Glucose regulates expression of pro-inflammatory genes, IL-1 and IL-12, through a mechanism involving hexosamine biosynthesis pathway-dependent regulation of α-E catenin

Waruni C. Dissanayake et al.

Summary: High glucose levels can rapidly increase the level of alpha-E catenin in macrophages, with the hexosamine biosynthesis pathway involved in this process. Alpha-E catenin can sense changes in glucose levels and modulate the expression of inflammatory markers induced by glucose.

BIOSCIENCE REPORTS (2021)

Review Biochemistry & Molecular Biology

Glucose Variability: How Does It Work?

Vadim V. Klimontov et al.

Summary: Glucose variability plays a crucial role in the development of diabetes complications, affecting target organs through oxidative stress, glycation, chronic inflammation, and other pathways. This creates a vicious cycle that worsens the condition and highlights the need to consider GV as a therapeutic target in diabetes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Integrative & Complementary Medicine

Two methoxy derivatives of resveratrol, 3,3′,4,5′-tetramethoxy-trans-stilbene and 3,4′,5-trimethoxy-trans-stilbene, suppress lipopolysaccharide-induced inflammation through inactivation of MAPK and NF-κB pathways in RAW 264.7 cells

Chunxiu Zhou et al.

Summary: 3,3 ',4,5'-TMS and 3,4', 5-TMS significantly suppressed LPS-induced inflammation in RAW 264.7 cells through inhibition of MAPK and NF-kappa B signaling pathways and also provided anti-oxidative effect.

CHINESE MEDICINE (2021)

Article Biochemistry & Molecular Biology

Beyond repression of Nrf2: An update on Keap1

Aleksandra Kopacz et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Article Immunology

Bromosulfophthalein suppresses inflammatory effects in lipopolysaccharide-stimulated RAW264.7 macrophages

Fuai Cui et al.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2020)

Review Pharmacology & Pharmacy

Obesity and NRF2-mediated cytoprotection: Where is the missing link?

Liliya V. Vasileva et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Food Science & Technology

Resveratrol-induced brown fat-like phenotype in 3T3-L1 adipocytes partly via mTOR pathway

Zihui Liu et al.

FOOD & NUTRITION RESEARCH (2020)

Article Dentistry, Oral Surgery & Medicine

Perillyl alcohol has antibacterial effects and reduces ROS production in macrophages

Rebeca Dantas Alves Figueiredo et al.

JOURNAL OF APPLIED ORAL SCIENCE (2020)

Review Biochemistry & Molecular Biology

Resveratrol: Review on its discovery, anti-leukemia effects and pharmacokinetics

Xiang-tao Huang et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2019)

Review Immunology

The Metabolic Signature of Macrophage Responses

Antonella Viola et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Biochemistry & Molecular Biology

Biochemistry of proinflammatory macrophage activation

Yannic Nonnenmacher et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

Review Medical Laboratory Technology

Macrophage polarization and meta-inflammation

Chuan Li et al.

TRANSLATIONAL RESEARCH (2018)

Review Biochemistry & Molecular Biology

Inflammasome, Inflammation, and Tissue Homeostasis

Vijay A. K. Rathinam et al.

TRENDS IN MOLECULAR MEDICINE (2018)

Article Multidisciplinary Sciences

Transcriptional profiling identifies novel regulators of macrophage polarization

Kimberline Y. Gerrick et al.

PLOS ONE (2018)

Review Neurosciences

Adipaging': ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue

Laura M. Perez et al.

JOURNAL OF PHYSIOLOGY-LONDON (2016)

Review Nutrition & Dietetics

Resveratrol and Cardiovascular Diseases

Dominique Bonnefont-Rousselot

NUTRIENTS (2016)

Review Geriatrics & Gerontology

Ageing, adipose tissue, fatty acids and inflammation

Chathyan Pararasa et al.

BIOGERONTOLOGY (2015)

Article Multidisciplinary Sciences

Glucose Controls Morphodynamics of LPS-Stimulated Macrophages

Gerda Venter et al.

PLOS ONE (2014)

Review Cardiac & Cardiovascular Systems

A Comprehensive Review on Metabolic Syndrome

Jaspinder Kaur

CARDIOLOGY RESEARCH AND PRACTICE (2014)

Article Medicine, Research & Experimental

Resveratrol in metabolic health: an overview of the current evidence and perspectives

Morten Moller Poulsen et al.

RESVERATROL AND HEALTH (2013)

Article Cardiac & Cardiovascular Systems

Effects of Nitric Oxide on Cell Proliferation Novel Insights

Claudio Napoli et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)

Review Immunology

Exploring the full spectrum of macrophage activation

David M. Mosser et al.

NATURE REVIEWS IMMUNOLOGY (2008)

Article Multidisciplinary Sciences

Inflammation and metabolic disorders

Goekhan S. Hotamisligil

NATURE (2006)