4.6 Article

A Reliable Method Based on Liquid Chromatography-Tandem Mass Spectrometry for the Simultaneous Quantification of Neurotransmitters in Caenorhabditis elegans

Related references

Note: Only part of the references are listed.
Review Cell Biology

The Roles of Serotonin in Neuropsychiatric Disorders

Mahsa Pourhamzeh et al.

Summary: The serotonergic system plays a crucial role in regulating various functions in the central nervous system and gastrointestinal tract. Deficiencies in this system can lead to pathological conditions like depression and schizophrenia. Research highlights the involvement of serotonin in neuropsychiatric disorders and discusses potential new therapies based on molecular mechanisms.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2022)

Review Biochemistry & Molecular Biology

Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration-Insights into disease mechanisms and current therapeutic approaches

Nadine Huber et al.

Summary: Frontotemporal lobar degeneration (FTLD) is a group of fatal neurodegenerative diseases for which there are no validated diagnostic or prognostic biomarkers or effective treatments. Research suggests that targeting disturbances in neurotransmitter systems may offer new therapeutic options for treating patients with FTLD.

MOLECULAR PSYCHIATRY (2022)

Article Neurosciences

Sexually Dimorphic Neurotransmitter Release at the Neuromuscular Junction in Adult Caenorhabditis elegans

Zhenzhen Yan et al.

Summary: Sexual dimorphism in neurotransmitter release at the neuromuscular junctions (NMJs) of adult Caenorhabditis elegans has been observed. Adult males show enhanced neurotransmitter release and increased sensitivity to extracellular calcium concentration in their cholinergic synapses. Furthermore, male cholinergic synapses exhibit weaker synaptic depression but faster vesicle replenishment compared to hermaphrodites.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)

Review Biophysics

Molecular Mechanisms Underlying Neurotransmitter Release

Josep Rizo

Summary: Recent advances in understanding the mechanism of neurotransmitter release have revealed a model involving SNARE proteins, NSF, SNAPs, Munc18-1, Munc13-1, synaptotagmin-1, and complexin. These proteins interact in a tightly regulated pathway to ensure membrane fusion and release of neurotransmitters, providing insights into presynaptic plasticity mechanisms.

ANNUAL REVIEW OF BIOPHYSICS (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

Striatal Acetylcholine-Dopamine Imbalance in Parkinson Disease: In Vivo Neuroimaging Study with Dual-Tracer PET and Dopaminergic PET-Informed Correlational Tractography

Carlos A. Sanchez-Catasus et al.

Summary: This study examines the acetylcholine-dopamine imbalance in Parkinson's disease patients using neuroimaging techniques. The results provide evidence for the existence of striatal acetylcholine-dopamine imbalance in early PD and suggest the possibility of using therapeutic strategies to restore this balance.

JOURNAL OF NUCLEAR MEDICINE (2022)

Review Pharmacology & Pharmacy

Modelling Parkinson's Disease in C. elegans: Strengths and Limitations

Liang Ma et al.

Summary: Parkinson's disease is a common neurodegenerative disease that affects the motor system and worsens with age. Current treatment options mainly target symptoms due to limited understanding of the disease's causes and mechanisms. Various preclinical models, including C. elegans, have been developed to study the disease and test potential treatments.

CURRENT PHARMACEUTICAL DESIGN (2022)

Article Environmental Sciences

Characterization of neurotransmitters and related metabolites in Daphnia magna juveniles deficient in serotonin and exposed to neuroactive chemicals that affect its behavior: A targeted LC-MS/MS method

Inmaculada Fuertes et al.

Summary: A study was conducted to develop an accurate analysis method for neurotransmitters in Daphnia magna. The results showed how neurotransmitter systems in D. magna are affected by chemical compounds, validating the importance of analyzing neurotransmitter levels in environmental neurotoxicity studies.

CHEMOSPHERE (2021)

Review Medical Laboratory Technology

Dopamine in Parkinson's disease

Saad Latif et al.

Summary: This article briefly reviews the synthesis pathway of dopamine in Parkinson's disease, its distribution and receptor family, as well as the compounds formed during the oxidation process. By discussing the role of dopamine and its mechanism in Parkinson's disease, it reveals its dual effects in neurotoxicity and neuroprotection.

CLINICA CHIMICA ACTA (2021)

Review Neurosciences

Glia: A major player in glutamate-GABA dysregulation-mediated neurodegeneration

Anika Sood et al.

Summary: This review highlights the role of glia in maintaining the excitatory-inhibitory balance in the central nervous system and its interaction with neurons, emphasizing the potential of glial receptors and proteins as drug targets for neurodegenerative diseases.

JOURNAL OF NEUROSCIENCE RESEARCH (2021)

Review Pharmacology & Pharmacy

Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits

Shreyas Bhat et al.

Summary: Neurotransmitter transporters play a crucial role in the central nervous system, and dysfunction can lead to various neurological disorders such as epilepsy, intellectual disability, or Parkinson's disease. Recent studies have linked genetic point mutations in NTTs to the onset of neurological disorders and have identified some folding-deficient variants that can be rescued by small molecules.

PHARMACOLOGY & THERAPEUTICS (2021)

Article Chemistry, Analytical

Enhanced Tb(III) fluorescence on gelatin-coated silver nanoparticles in dopamine detection

Jia Sun et al.

Summary: A composite fluorescent nanoprobe based on metal enhanced fluorescence effect of gelatin-coated silver nanoparticles was developed for selective and sensitive detection of dopamine. The probe showed a low detection limit and good selectivity, making it a promising approach for dopamine detection in human serum samples.

TALANTA (2021)

Editorial Material Biochemistry & Molecular Biology

Serotonin in Health and Disease

Philippe De Deurwaerdere et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Nutrition & Dietetics

Maintaining Translational Relevance in Animal Models of Manganese Neurotoxicity

Cherish A. Taylor et al.

JOURNAL OF NUTRITION (2020)

Article Biochemical Research Methods

LC-MS/MS analysis of twelve neurotransmitters and amino acids in mouse cerebrospinal fluid

Maria Encarnacion Blanco et al.

JOURNAL OF NEUROSCIENCE METHODS (2020)

Article Biochemical Research Methods

Quantification of neurotransmitters in microdialysate samples following quetiapine dosing to schizophrenia phenotyped rats using a validated LC-MS/MS method

Fernando Carreno et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2020)

Article Spectroscopy

Carbon dots-based dual-emission ratiometric fluorescence sensor for dopamine detection

Jia An et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2020)

Article Cell Biology

Modeling neurodegeneration in Caenorhabditis elegans

Kim A. Caldwell et al.

DISEASE MODELS & MECHANISMS (2020)

Article Biochemistry & Molecular Biology

A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function

Andrew C. Giles et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Biochemical Research Methods

LC-MS/MS-based quantification of tryptophan metabolites and neurotransmitters in the serum and brain of mice

Li-Sha Wang et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2019)

Review Neurosciences

Impaired dopamine metabolism in Parkinson's disease pathogenesis

Anna Masato et al.

MOLECULAR NEURODEGENERATION (2019)

Review Cell Biology

Dopamine: Functions, Signaling, and Association with Neurological Diseases

Marianne O. Klein et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2019)

Article Pharmacology & Pharmacy

C-elegans as a model in developmental neurotoxicology

Joanna A. Ruszkiewicz et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

Review Neurosciences

Modeling Parkinson's Disease in C. elegans

Jason F. Cooper et al.

JOURNAL OF PARKINSONS DISEASE (2018)

Article Neurosciences

Dopamine Autoxidation Is Controlled by Acidic pH

Nejc Umek et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

Review Toxicology

The C-elegans model in toxicity testing

Piper Reid Hunt

JOURNAL OF APPLIED TOXICOLOGY (2017)

Review Chemistry, Medicinal

Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015)

Stanton F. McHardy et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2017)

Review Neurosciences

Dopamine and Acetylcholine, a Circuit Point of View in Parkinson's Disease

Giorgio Rizzi et al.

FRONTIERS IN NEURAL CIRCUITS (2017)

Review Cell Biology

Drosophila models of prionopathies: insight into prion protein function, transmission, and neurotoxicity

Pedro Fernandez-Funez et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2017)

Article Neurosciences

Alzheimer's Disease: Targeting the Cholinergic System

Talita H. Ferreira-Vieira et al.

CURRENT NEUROPHARMACOLOGY (2016)

Article Engineering, Environmental

Changes in Neurotransmitter Profiles during Early Zebrafish (Danio rerio) Development and after Pesticide Exposure

Sara Tufi et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2016)

Article Multidisciplinary Sciences

Pharyngeal pumping in Caenorhabditis elegans depends on tonic and phasic signaling from the nervous system

Nicholas F. Trojanowski et al.

SCIENTIFIC REPORTS (2016)

Article Chemistry, Analytical

Analysis of amino acid neurotransmitters from rat and mouse spinal cords by liquid chromatography with fluorescence detection

Nurullah Sanli et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2015)

Article Biochemical Research Methods

Simultaneous quantification of seven hippocampal neurotransmitters in depression mice by LC-MS/MS

Fei Huang et al.

JOURNAL OF NEUROSCIENCE METHODS (2014)

Article Chemistry, Analytical

Derivatization for the simultaneous LC/MS quantification of multiple neurotransmitters in extracellular fluid from rat brain microdialysis

Minli Zhang et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2014)

Article Multidisciplinary Sciences

A Heuristic Model of Alcohol Dependence

Zhen Qi et al.

PLOS ONE (2014)

Article Biochemical Research Methods

A stable isotope-labeled internal standard is essential for correcting for the interindividual variability in the recovery of lapatinib from cancer patient plasma in quantitative LC-MS/MS analysis

Jianmei Wu et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2013)

Review Biochemistry & Molecular Biology

Tyrosine hydroxylase and regulation of dopamine synthesis

S. Colette Daubner et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2011)

Article Biochemical Research Methods

Analysis of synaptic transmission in Caenorhabditis elegans using an aldicarb-sensitivity assay

Timothy R. Mahoney et al.

NATURE PROTOCOLS (2006)

Article Biochemical Research Methods

Simple and rapid determination of serotonin and catecholamines in biological tissue using high-performance liquid chromatography with electrochemical detection

BA Patel et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2005)