Journal
MOLECULAR MEDICINE REPORTS
Volume 14, Issue 6, Pages 5528-5534Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2016.5929
Keywords
resveratrol; senescence; endothelial progenitor cell; oxidative reaction
Categories
Funding
- National Natural Science Foundation of China [81001435]
- Medical Science and Technology Foundation of Zhejiang Province [2012RCA034]
Ask authors/readers for more resources
Increasing evidence suggests endothelial progenitor cells (EPCs) improve neovascularization and endothelium regeneration. Resveratrol (RSV) is a natural polyphenolic compound, which has been demonstrated to exert multiple protective effects on the cardiovascular system, including inhibition of platelet adhesion and aggregation, reduction of myocardial ischemia-reperfusion injury, and suppression of neointimal hyperplasia of injured vascular tissue. The present study investigated the role of RSV on levels of oxidative stress and senescence of EPCs, and the effects of RSV on vascular-promoting and/or vascular-healing capacity of EPCs. It was demonstrated that EPCs could promote the repair of endothelium of the injured artery. RSV reduced the oxidative reaction of EPCs and inhibited EPC senescence, and these effects may occur via the peroxisome proliferator-activated receptor-gamma/heme oxygenase-1 signaling pathways.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available