Single-cell dissection of cellular and molecular features underlying mesenchymal stem cell therapy in ischemic acute kidney injury

Article Transplantation

Knockout of Zeb2 ameliorates progression of renal tubulointerstitial fibrosis in a mouse model of renal ischemia-reperfusion injury

Satoshi Inotani et al.

Summary: Zeb2 plays a regulatory role in the pathogenesis of acute kidney injury (AKI) and AKI-to-chronic kidney disease (CKD) transition by regulating fibrotic pathways. Inhibition of Zeb2 could be a potential therapeutic strategy for AKI.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2022)

Add to Collection

Article Immunology

Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis

Tomohito Doke et al.

Summary: The study reveals that fibrotic tubular cells in the kidney recruit basophils, which contribute to immune responses and kidney fibrosis. These findings are validated in both mouse models and human kidney samples, suggesting that targeting basophils might be a potential clinical strategy for managing chronic kidney disease.

NATURE IMMUNOLOGY (2022)

Add to Collection

Article Cell & Tissue Engineering

Hypoxic mesenchymal stem cell-derived extracellular vesicles ameliorate renal fibrosis after ischemia-reperfusion injure by restoring CPT1A mediated fatty acid oxidation

Zhumei Gao et al.

Summary: Hypo-EVs show superior therapeutic effects in repairing renal structure damage, restoring renal function, and reducing renal fibrosis. They enhance mitochondrial FAO by restoring the expression of the key enzyme CPT1A, leading to improved mitochondrial homeostasis and attenuation of I/R damage.

STEM CELL RESEARCH & THERAPY (2022)

Add to Collection

Article Cell & Tissue Engineering

Comparison of the treatment efficacy of umbilical mesenchymal stem cell transplantation via renal subcapsular and parenchymal routes in AKI-CKD mice

Mengjie Huang et al.

Summary: In this study, subcapsular mesenchymal stem cells (MSCs) transplantation was found to have better therapeutic effects in the treatment of acute kidney injury (AKI). Collagen matrix provided a superior microenvironment for stabilizing the retention of MSCs in the kidney.

STEM CELL RESEARCH & THERAPY (2022)

Add to Collection

Article Materials Science, Biomaterials

Artificial Kidney Capsule Packed with Mesenchymal Stem Cell-Laden Hydrogel for the Treatment of Rhabdomyolysis-Induced Acute Kidney Injury

Zhangning Fu et al.

Summary: Acute kidney injury (AKI) is a major global public health problem with a lack of effective therapies. A novel therapeutic strategy involving a customizable artificial kidney capsule (AKC) and MSC-laden hydrogel is proposed for AKI treatment. The strategy has been shown to reduce kidney damage and could be a promising alternative for AKI treatment.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

Add to Collection

Review Chemistry, Medicinal

Extracellular vesicles: Emerging frontiers in wound healing

Mangesh D. Hade et al.

Summary: Extracellular vesicles are important for intercellular communication and have potential roles in cell differentiation, angiogenesis, stress response, and immune signaling. Due to their biocompatibility and efficient cargo delivery, they are considered ideal candidates for regenerative medicine.

MEDICINAL RESEARCH REVIEWS (2022)

Add to Collection

Article Medicine, Research & Experimental

Transient upregulation of EGR1 signaling enhances kidney repair by activating SOX9+ renal tubular cells

Jian-Wen Chen et al.

Summary: The study found that EGR1 plays a key role in kidney regeneration in AKI. It promotes SOX9(+) cell proliferation by activating the Wnt/beta-catenin pathway.

THERANOSTICS (2022)

Add to Collection

Article Multidisciplinary Sciences

Inference and analysis of cell-cell communication using CellChat

Suoqin Jin et al.

Summary: By constructing an interaction database and developing the tool CellChat, the authors quantitatively inferred and analyzed cell-cell communication networks, revealing important signaling inputs and outputs between cells, and achieved classification of conserved and context-specific pathways.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Cell & Tissue Engineering

Ultrasound enhances the therapeutic potential of mesenchymal stem cells wrapped in greater omentum for aristolochic acid nephropathy

Yuanjun Yang et al.

Summary: This study demonstrated that ultrasound-guided injection of MSCs into the greater omentum surrounding the kidney improved renal function, attenuated kidney injury, and mitigated renal interstitial fibrosis and inflammatory responses, making it a potentially safe and effective therapy for chronic kidney disease.

STEM CELL RESEARCH & THERAPY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Mesenchymal Stem Cell-Derived Extracellular Vesicles to the Rescue of Renal Injury

Lucy Birtwistle et al.

Summary: This review discusses mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) as a novel therapeutic approach for chronic kidney disease, highlighting their ability to promote kidney regeneration and slow down the progression of pathophysiological pathways.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Cell & Tissue Engineering

Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor-β receptor inhibition

Yan Zhang et al.

Summary: Both UCB-MSCs and UCB-MSC-exo can accelerate wound healing, reduce scar formation, and improve the regeneration of skin appendages, nerves, and vessels, as well as regulate the natural distribution of collagen fibers in wound healing. UCB-MSC-exo also suppress excessive formation of myofibroblasts and collagen I.

STEM CELL RESEARCH & THERAPY (2021)

Add to Collection

Article Medicine, Research & Experimental

Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury

Jing-Yuan Cao et al.

Summary: In this study, MSC-exos were found to preferentially target injured kidneys and localize to proximal tubules in ischemic AKI. The researchers demonstrated that MSC-exos ameliorated ischemic AKI and promoted tubular repair by targeting the cell cycle arrest and apoptosis of TECs through the miR-125b-5p/p53 pathway. This study provides new insights into the role of MSC-exos in renal tubule repair and highlights their potential as a promising therapeutic strategy for AKI.

THERANOSTICS (2021)

Add to Collection

Review Urology & Nephrology

Mesenchymal stromal cell ? based therapies for acute kidney injury: progress in the last decade

Barbara Fazekas et al.

KIDNEY INTERNATIONAL (2020)

Add to Collection

Review Chemistry, Multidisciplinary

Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration

Meadhbh A. Brennan et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Supramolecular Nanofibers Containing Arginine-Glycine-Aspartate (RGD) Peptides Boost Therapeutic Efficacy of Extracellular Vesicles in Kidney Repair

Chuyue Zhang et al.

ACS NANO (2020)

Add to Collection

Article Medicine, Research & Experimental

Xenogeneic mesenchymal stem cell transplantation for mandibular defect regeneration

Boon Ching Tee et al.

XENOTRANSPLANTATION (2020)

Add to Collection

Review Cell & Tissue Engineering

What is the impact of human umbilical cord mesenchymal stem cell transplantation on clinical treatment?

Qixin Xie et al.

STEM CELL RESEARCH & THERAPY (2020)

Add to Collection

Article Medicine, Research & Experimental

Embryonic stem cell-derived mesenchymal stem cells promote colon epithelial integrity and regeneration by elevating circulating IGF-1 in colitis mice

Jun Xu et al.

THERANOSTICS (2020)

Add to Collection

Article Biochemistry & Molecular Biology

DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors

Christopher S. McGinnis et al.

CELL SYSTEMS (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Comprehensive Integration of Single-Cell Data

Tim Stuart et al.

CELL (2019)

Add to Collection

Review Medicine, General & Internal

Acute kidney injury

Claudio Ronco et al.

LANCET (2019)

Add to Collection

Article Cardiac & Cardiovascular Systems

CXCL1-CXCR2 axismediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation ofmonocyte infiltration

Lei Wang et al.

EUROPEAN HEART JOURNAL (2018)

Add to Collection

Article Urology & Nephrology

IL-17A improves the efficacy of mesenchymal stem cells in ischemic-reperfusion renal injury by increasing Treg percentages by the COX-2/PGE2 pathway

Ming Bai et al.

KIDNEY INTERNATIONAL (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

Xinyi Guo et al.

NATURE MEDICINE (2018)

Add to Collection

Article Cell & Tissue Engineering

Pericellular collagen I coating for enhanced homing and chondrogenic differentiation of mesenchymal stem cells in direct intra-articular injection

Hansong Xia et al.

STEM CELL RESEARCH & THERAPY (2018)

Add to Collection

Article Rheumatology

CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis

Harini Raghu et al.

ANNALS OF THE RHEUMATIC DISEASES (2017)

Add to Collection

Article Urology & Nephrology

Sustained Activation of Wnt/β-Catenin Signaling Drives AKI to CKD Progression

Liangxiang Xiao et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Add to Collection

Review Pharmacology & Pharmacy

Regenerative pharmacology for the treatment of acute kidney injury: Skeletal muscle stem/progenitor cells for renal regeneration?

Egle Pavyde et al.

PHARMACOLOGICAL RESEARCH (2016)

Add to Collection

Review Cell & Tissue Engineering

Mesenchymal stem cell-based therapy in kidney transplantation

Cheng Chen et al.

STEM CELL RESEARCH & THERAPY (2016)

Add to Collection

Article Biochemistry & Molecular Biology

MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation

Xiaorong Zhang et al.

CELL (2014)

Add to Collection

Article Biotechnology & Applied Microbiology

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

Cole Trapnell et al.

NATURE BIOTECHNOLOGY (2014)

Add to Collection

Article Cell Biology

Single-step isolation of extracellular vesicles by size-exclusion chromatography

Anita N. Boing et al.

JOURNAL OF EXTRACELLULAR VESICLES (2014)

Add to Collection

Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)

Add to Collection

Review Endocrinology & Metabolism

Extracellular vesicles as an emerging mechanism of cell-to-cell communication

Ciro Tetta et al.

ENDOCRINE (2013)

Add to Collection

Article Immunology

Which Is the Most Suitable and Effective Route of Administration for Mesenchymal Stem Cell-Based Immunomodulation Therapy in Experimental Kidney Transplantation: Endovenous or Arterial?

S. Zonta et al.

TRANSPLANTATION PROCEEDINGS (2010)

Add to Collection

Article Medicine, Research & Experimental

Mesenchymal stem cells induce a weak immune response in the rat striatum after allo or xenotransplantation

Julien Rossignol et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)

Add to Collection

Article Urology & Nephrology

Incidence and outcomes in acute kidney injury: A comprehensive population-based study

Tariq Ali et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2007)

Add to Collection

Article Surgery

Mesenchymal stem cells enhance xenochimerism in NK-depleted hosts

Ada Moadsiri et al.

SURGERY (2006)

Add to Collection

Article Biochemistry & Molecular Biology

Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin

JY Long et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Add to Collection

Single-cell dissection of cellular and molecular features underlying mesenchymal stem cell therapy in ischemic acute kidney injury

Related references

Export Citation

Share Paper